What is Hexapeptide-2
Hexapeptide-2 is a synthetic peptide composed of six amino acids with the sequence H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂. It acts as an antagonist to α-MSH (α-melanocyte-stimulating hormone) – the natural signal that triggers melanin production in the skin. By blocking this signal, Hexapeptide-2 helps reduce unwanted pigmentation, even out skin tone, and brighten overall complexion. It also supports anti-aging by promoting collagen production and reducing the appearance of fine lines and wrinkles. This gentle, well-tolerated peptide is suitable for all skin types and is widely used in brightening serums, spot correctors, and anti-aging creams.
Key Features & Advantages
- Brightening Action – Acts as an α-MSH antagonist to reduce melanin production and even out skin tone
- Fades Dark Spots – Helps lighten hyperpigmentation, sun spots, and uneven patches
- Supports Anti-Aging – Promotes collagen production to help reduce fine lines and wrinkles
- Gentle & Well-Tolerated – Low irritation and low allergen potential; suitable for sensitive skin
- High Purity – Available in ≥95% and ≥98% purity (HPLC) with full analytical documentation
- Excellent Formulation Compatibility – Suitable for serums, creams, lotions, masks, and eye contour products
- Versatile Skin Types – Suitable for normal, dry, combination, oily, and sensitive skin
- Synthetic & Animal-Free – 100% synthetic production; vegan and cruelty-free
Technical Specifications (Typical – ≥98% Grade)
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Hexapeptide-2 | - |
| CAS Number | 87616-84-0 | - |
| INCI Name | Hexapeptide-2 | - |
| Synonyms | Melanostatine 2; GHRP-6; 六肽-2 | - |
| Amino Acid Sequence | H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂ | - |
| Molecular Formula | C₄₆H₅₆N₁₂O₆ | - |
| Molecular Weight | ~873 g/mol | - |
| Appearance | White to off-white powder | Visual |
| Assay (Purity) | ≥98.0% (HPLC) | HPLC |
| Purity (≥95% grade) | ≥95.0% (HPLC) | HPLC |
| Solubility | Soluble in water and DMSO | - |
| Storage | 2°C – 8°C (short-term); -20°C (long-term) | - |
| Heavy Metals | Compliant with cosmetic standards | ICP-MS |
| Total Plate Count | ≤100 CFU/g | USP <61> |
| Yeast & Mold | ≤10 CFU/g | USP <2021> |
| E. coli | Negative | USP <2022> |
| Salmonella | Negative | USP <2022> |
Specifications are for reference. Please request the current COA for batch-specific data.
Skin Benefits
1. Brightens Skin and Evens Out Tone
Hexapeptide-2 works by blocking the hormonal signal (α-MSH) that triggers melanin production. By reducing excess pigment formation, it helps brighten dull skin, even out uneven tone, and restore a more radiant complexion.
2. Fades Dark Spots and Hyperpigmentation
Studies have shown that Hexapeptide-2 is effective at lightening existing dark spots, sun spots, and other forms of hyperpigmentation. It helps reduce unwanted pigmentation and prevents new spots from forming.
3. Supports Firmer, Smoother Skin
Hexapeptide-2 promotes collagen production in the skin. This helps improve skin firmness and elasticity, reducing the appearance of fine lines and wrinkles over time.
4. Gentle on All Skin Types
Hexapeptide-2 has low irritation and low allergen potential. It is well-tolerated and suitable for all skin types, including sensitive skin.
5. Supports Overall Skin Health
Beyond brightening and anti-aging, Hexapeptide-2 also functions as a skin conditioning agent, helping maintain the skin in good condition.
Applications
- Brightening Serums & Ampoules – High-performance formulations targeting dullness and uneven skin tone
- Dark Spot Correctors – Targeted treatments for hyperpigmentation, sun spots, and age spots
- Even-Tone Creams – Daily formulations for maintaining a balanced, radiant complexion
- Anti-Aging Creams & Serums – Products combining brightening with collagen-supporting benefits
- Eye Contour Products – Gentle formulations for the delicate eye area
- Daily Moisturizers – Preventative skincare for all skin types
- Sheet Masks & Leave-On Treatments – Concentrated brightening and anti-aging treatments
- Sun Care & After-Sun Products – Formulations to prevent and address sun-induced pigmentation
Frequently Asked Questions (FAQ)
Q: What is Hexapeptide-2?
A: Hexapeptide-2 is a synthetic peptide composed of six amino acids that acts as an antagonist to α-MSH (the hormone that triggers melanin production). It helps brighten skin, even out tone, and fade dark spots.
Q: What is the difference between Hexapeptide-2 and GHRP-6?
A: Hexapeptide-2 and GHRP-6 (Growth Hormone Releasing Peptide-6) refer to the same peptide. Hexapeptide-2 is the INCI name used in cosmetics, while GHRP-6 is the name more commonly used in research and pharmaceutical contexts.
Q: Is Hexapeptide-2 safe for use during pregnancy?
A: Hexapeptide-2 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal. As with any skincare ingredient, we recommend consulting a healthcare provider before use during pregnancy or breastfeeding.
Q: Is Hexapeptide-2 suitable for sensitive skin?
A: Yes. Hexapeptide-2 has low irritation and low allergen potential and is suitable for all skin types, including sensitive skin.
Q: What are the recommended usage levels?
A: Recommended usage typically ranges from 0.01% to 5% in finished cosmetic formulations, depending on the product type and desired efficacy. We recommend conducting stability and efficacy testing for your specific formulation.
Q: What is the optimal pH range for stability?
A: Hexapeptide-2 is stable across a broad pH range of 4.0 – 7.5, making it compatible with most cosmetic formulations.
Q: At what stage should Hexapeptide-2 be added to formulations?
A: Add during the cooling phase (below 45°C) at the final stage of formulation to preserve peptide bioactivity.
Q: What ingredients work well with Hexapeptide-2?
A: Hexapeptide-2 works synergistically with:
- Nonapeptide-1 – Dual-mechanism brightening
- Niacinamide – Enhanced brightening and barrier support
- Vitamin C derivatives – Enhanced antioxidant protection and brightening
- Biotin – Biotin-conjugated Hexapeptide-2 has been shown to significantly increase type I collagen biosynthesis
Why Choose Us?
✔ We can provide you with customized services, such as OEM, and ODM services.
✔ We guarantee that if there is a quality problem, you can return or refund within one month.
✔ We have professional product quotations and product catalogs.
✔ Our products have a certificate of inspection certified by an international company
✔ When we have sufficient inventory, we can quickly deliver goods to customers.
✔ We have a professional team and rich experience
Contact Us
For bulk inquiries, samples, or custom specifications, please contact our sales team. We look forward to partnering with you for high‑quality Hexapeptide-2 Powder that meets your exact requirements. Email: ella.zhang@huilinbio-tech.com.
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