Introduction
Hexapeptide-11, also known as Peptamide 6, is a synthetic signaling peptide composed of six amino acids with the sequence Phe-Val-Ala-Pro-Phe-Pro (FVAPFP). It was originally isolated from yeast extracts and is now produced through solid-state synthesis to high purity. Hexapeptide-11 works by stimulating fibroblasts in the skin to produce more collagen and elastin, helping to improve firmness, elasticity, and overall skin quality. It also supports skin barrier function and offers antioxidant protection. This versatile peptide is widely used in anti-aging serums, firming creams, barrier repair products, and hair care formulations.
Key Features & Advantages
- Signaling Peptide – Stimulates fibroblasts to produce collagen and elastin, supporting skin structure from within
- Supports Skin Firmness & Elasticity – Helps improve skin's bounce and resilience
- Barrier Support – Enhances skin barrier function and supports hydration
- Antioxidant Protection – Activates skin's natural antioxidant defense system
- Protects Against Premature Aging – Shields fibroblasts from oxidative stress that accelerates visible aging
- High Purity – Available in ≥95% and ≥98% purity (HPLC) with full analytical documentation
- Excellent Water Solubility – Easy to incorporate into aqueous formulations
- Synthetic & Animal-Free – 100% synthetic production; vegan and cruelty-free
- Proven Efficacy – Backed by published research showing measurable improvements in skin elasticity
Technical Specifications (Typical – ≥98% Grade)
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Hexapeptide-11 (Peptamide 6) | - |
| CAS Number | 161258-30-6 | - |
| INCI Name | Hexapeptide-11 | - |
| Synonyms | Peptamide 6; 六肽-11; 六胜肽-11 | - |
| Amino Acid Sequence | H-Phe-Val-Ala-Pro-Phe-Pro-OH (FVAPFP) | - |
| Molecular Formula | C₃₆H₄₈N₆O₇ | - |
| Molecular Weight | ~676.8 g/mol | - |
| Appearance | White to off-white powder | Visual |
| Assay (Purity) | ≥98.0% (HPLC) | HPLC |
| Purity (≥95% grade) | ≥95.0% (HPLC) | HPLC |
| Solubility | Soluble in water and DMSO | - |
| pH Stability Range | 3.5 – 7.2 | - |
| Loss on Drying | ≤5.0% | 105°C |
| Heavy Metals | Compliant with cosmetic standards | ICP-MS |
| Total Plate Count | ≤100 CFU/g | USP <61> |
| Yeast & Mold | ≤10 CFU/g | USP <2021> |
| E. coli | Negative | USP <2022> |
| Salmonella | Negative | USP <2022> |
Specifications are for reference. Please request the current COA for batch-specific data.
Skin Benefits
Supports Firmer, More Elastic Skin
Hexapeptide-11 signals skin cells to produce more collagen and elastin – the proteins that keep skin firm and bouncy. Research shows it has a positive impact on skin elasticity and firmness.
Reduces Fine Lines and Wrinkles
By boosting collagen production, Hexapeptide-11 helps smooth out fine lines and wrinkles, making it an excellent addition to anti-aging products.
Protects Skin from Premature Aging
Hexapeptide-11 protects fibroblasts (the cells that produce collagen) from oxidative stress that can cause premature aging. It also activates the skin's own antioxidant defense system.
Strengthens Skin Barrier
This peptide helps enhance skin barrier function and promotes hydration, supporting healthier, more resilient skin.
Supports Skin Longevity
Preliminary research indicates that Hexapeptide-11 shows promise for improving skin's healthspan by interacting with aging cells.
Gentle and Well-Tolerated
Hexapeptide-11 is suitable for all skin types, including sensitive skin, with no reported irritation at recommended usage levels.
Applications
- Anti-Aging Serums & Ampoules – High-performance formulations targeting fine lines, wrinkles, and loss of firmness
- Firming & Elasticity Creams – Products specifically designed to restore skin's bounce and resilience
- Barrier Repair Formulations – Skincare for compromised or sensitive skin
- Eye Contour Treatments – Gentle formulations for the delicate eye area
- Daily Moisturizers – Preventative anti-aging products for all skin types
- Hair Care – Nourishing and scalp-supporting formulations
- Professional Aesthetic Skincare – Clinical-strength products for professional and home use
OME service
Packaging & Shipping
Certification
Frequently Asked Questions (FAQ)
Q: Where does Hexapeptide-11 come from?
A: Hexapeptide-11 was originally isolated from yeast extracts (Saccharomyces cerevisiae). Today, it is produced synthetically through solid-state peptide synthesis to achieve high purity and batch-to-batch consistency.
Q: What is the recommended usage level in finished products?
A: Suppliers typically recommend usage levels between 0.001% to 0.01% for Hexapeptide-11 in finished cosmetic products. For concentrated active formulations, higher levels may be used depending on the application.
Q: What is the difference between Hexapeptide-11 and other anti-aging peptides?
A: Hexapeptide-11 is a signaling peptide that stimulates fibroblasts to produce collagen and elastin. What makes it unique is its additional ability to activate the skin's natural antioxidant defense system (the Nrf2 pathway) and protect fibroblasts from premature aging. It also supports skin barrier function by promoting hyaluronic acid production.
Q: Is Hexapeptide-11 suitable for sensitive skin?
A: Yes. Hexapeptide-11 is well-tolerated and suitable for all skin types, including sensitive skin. No irritation has been reported at recommended usage levels.
Q: Can Hexapeptide-11 be used in hair care products?
A: Yes. Hexapeptide-11 is recognized for its ability to support skin elasticity and firmness, as well as improve hair manageability.
Q: Is Hexapeptide-11 heat-stable?
A: Hexapeptide-11 is stable across a pH range of 3.5 – 7.2 and can tolerate temperatures up to 80°C. However, for optimal bioactivity, we recommend adding it during the cooling phase (below 45°C) at the final stage of formulation.
How To Contact Us?
For bulk inquiries, samples, or custom specifications, please contact our sales team. We look forward to partnering with you for high‑quality Hexapeptide-11 Powder that meets your exact requirements.
If you need this product for your product lines, please get in touch with us at ella.zhang@huilinbio-tech.com.
Hot Tags: Hexapeptide-11 Powder, China, suppliers, manufacturers, factory, wholesale, buy, price, bulk, pure, natural, high quality, in stock, for sale, Azelaic Acid Powder, Hydrolyzed Silk Powder, L Carnosine Powder, Laurocapram Azone Powder, Tocopherol Powder, Tranexamic Acid Powder 99
