Overview – At a Glance
Palmitoyl Tripeptide‑1 & Palmitoyl Tetrapeptide‑7 Complex, commonly known in the cosmetic industry as Matrixyl 3000 (domestic alias: Base Peptide 3000), is a branded peptide complex – not a single ingredient, but a precise two‑peptide system developed by Sederma (Croda group). It combines two biomimetic signal peptides:
- Palmitoyl Tripeptide‑1 (Pal‑GHK) – a palmitoylated fragment of type I collagen
- Palmitoyl Tetrapeptide‑7 (Pal‑GQPR) – a signalling peptide designed to interact with cellular mechanisms involved in dermal homeostasis
The name "Matrixyl" is derived from "matrikine" – a naturally occurring class of short peptide fragments that are released by the skin when collagen fibres break down. When collagen degrades, the body recognises the resulting peptide fragments as a distress signal and responds by upregulating collagen synthesis. Matrixyl 3000 is engineered to mimic this signal – essentially telling the skin to produce more collagen even in the absence of actual collagen damage.
The "3000" designation distinguishes it from earlier generations of the Matrixyl formulation. The third‑generation version introduced Palmitoyl Tetrapeptide‑7 alongside Palmitoyl Tripeptide‑1, creating a two‑part system where each peptide performs a complementary and distinct function – a dual‑mechanism design that makes the 3000 generation the most studied and referenced peptide complex in cosmetic science literature.
The complex is typically supplied as a 1:1 lipidated peptide blend dissolved in a glycerin‑water‑butylene glycol carrier matrix (INCI: Glycerin (and) Aqua (and) Butylene Glycol (and) Carbomer (and) Polysorbate 20 (and) Palmitoyl Tripeptide‑1 (and) Palmitoyl Tetrapeptide‑7). It is fully water‑soluble and stable across the cosmetic pH range, with peak stability at pH 5 to 7.
Our Palmitoyl Tripeptide‑1 & Palmitoyl Tetrapeptide‑7 Complex is manufactured through advanced Solid‑Phase Peptide Synthesis (SPPS) followed by N‑terminal palmitoylation, rigorous HPLC purification, and precise 1:1 blending. The result is a consistently pure, stable, and highly bioactive complex that meets the stringent quality requirements of prestige skincare brands worldwide.
Key Features & Advantages
- Dual‑Peptide Signal Complex – Combines two biomimetic matrikines (Pal‑GHK and Pal‑GQPR) for complementary and synergistic anti‑aging action
- Collagen Stimulation – Promotes synthesis of type I, III, IV, and VII collagen; in vitro studies demonstrate up to 258% – 350% increase in collagen production
- Inflammation Modulation – Palmitoyl Tetrapeptide‑7 reduces inflammatory signalling, decreasing skin matrix degradation common during aging
- Enhanced Skin Penetration – Palmitoyl (lipid) chains increase lipophilicity, stability, and affinity with epidermal lipids
- Clinically Proven Efficacy – Reduces deep wrinkles by up to 45% and improves skin texture by 16%
- Excellent Formulation Compatibility – Fully water‑soluble; stable across pH 4.0 – 7.5; suitable for aqueous, emulsion, and anhydrous systems
- Gentle & Well‑Tolerated – Non‑irritating, non‑sensitizing; safe alternative to retinoids with comparable efficacy
- Synthetic & Animal‑Free – 100% synthetic production via SPPS; vegan and cruelty‑free
- Regulatory Compliant – Listed in CosIng, PCPC INCI dictionary, and China IECIC
Technical Specifications (Typical – Standard Liquid Grade)
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Palmitoyl Tripeptide‑1 & Palmitoyl Tetrapeptide‑7 Complex | - |
| INCI Name | Glycerin (and) Aqua (and) Butylene Glycol (and) Carbomer (and) Polysorbate 20 (and) Palmitoyl Tripeptide‑1 (and) Palmitoyl Tetrapeptide‑7 | - |
| CAS No. (Tripeptide‑1) | 147732-56-7 | - |
| CAS No. (Tetrapeptide‑7) | 221227-05-0 | - |
| Appearance | Clear to pale yellow viscous liquid | Visual |
| Palmitoyl Tripeptide‑1 Content | 90 – 110 ppm | HPLC |
| Palmitoyl Tetrapeptide‑7 Content | 45 – 55 ppm | HPLC |
| Peptide Ratio | 1:1 (mass ratio) | HPLC |
| Solubility | Fully water‑soluble | - |
| pH Range | 3.0 – 9.0 (stable pH 4.0 – 7.5; optimal pH 5.0 – 7.0) | - |
| Heavy Metals | Compliant with cosmetic standards | ICP‑MS |
| Total Plate Count | ≤100 CFU/g | USP <61> |
| Yeast & Mold | ≤10 CFU/g | USP <2021> |
| E. coli | Negative | USP <2022> |
| Salmonella | Negative | USP <2022> |
Specifications are for reference. Please request the current COA for batch‑specific data.
Key Skin Benefits
Palmitoyl Tripeptide‑1 & Palmitoyl Tetrapeptide‑7 Complex (Matrixyl 3000) is one of the most clinically studied peptide complexes in cosmetic science. Here are the key benefits supported by research:
1. Stimulates Collagen Production – Up to 350% Increase
- Matrixyl 3000 acts as a signal peptide complex, communicating with skin cells to produce more collagen.
- In vitro studies demonstrate stimulation of collagen synthesis (types I, III, IV, and VII) and fibronectin.
- Research shows collagen production increases by 258% – 350%.
- This helps reduce wrinkles, improve skin thickness, and combat age‑related skin thinning.
2. Clinically Proven Wrinkle Reduction
- In a 2‑month in‑vivo study, Matrixyl 3000 demonstrated a 45% decrease in the surface occupied by deep wrinkles.
- Another study showed a 29.4% decrease in the area occupied by deep wrinkles (>200 µm) in men.
- Clinical studies report improvement in wrinkles, skin firmness, and elasticity after several weeks of use.
- Reduces skin age by 1.8 years after just 4 weeks.
3. Improves Skin Firmness, Elasticity & Texture
- Increases skin firmness and elasticity through enhanced collagen and elastin production.
- Improves skin texture and smoothness by 16%.
- Helps restore the biomechanical properties of aging skin.
4. Reduces Inflammation & Protects Skin Matrix
- Palmitoyl Tetrapeptide‑7 provides secondary anti‑inflammatory effects, reducing skin matrix degradation common during aging.
- Protects the skin's structural integrity and slows the aging process.
- Calms visible signs of sensitisation.
5. Repairs Age‑Related Skin Damage
- Matrixyl 3000 repairs the cutaneous damage of age.
- Contains matrikines which are messengers of cutaneous restructuring and repair – they activate the neosynthesis of extracellular matrix macromolecules.
- Helps rebuild the fine structure of the papillary dermis and reverses sun damage.
6. Gentle Retinoid Alternative
- At 5 ppm concentration, Palmitoyl Tripeptide‑1 demonstrates efficacy comparable to 0.05% vitamin A activity – but without the irritation.
- Irritation, sensitisation, and genotoxicity tests indicate a good safety profile.
- Suitable for sensitive skin and consumers seeking effective anti‑aging without retinoid side effects.
7. Supports Dermal Thickening & Barrier Function
- Promotes fibroblast proliferation and matrix macromolecule synthesis.
- Strengthens the dermal‑epidermal junction (DEJ).
- Improves skin barrier function and overall skin health.
Products Description
- Anti‑Aging Serums & Ampoules – High‑performance serums targeting wrinkles, fine lines, and loss of firmness.
- Eye Contour Creams & Serums – Gentle yet effective formulations for the delicate eye area (crow's feet, under‑eye wrinkles).
- Firming & Elasticity Formulations – Products specifically designed to restore skin's bounce and resilience.
- Post‑Procedure Repair Formulations – Products for use after laser, chemical peels, and microneedling.
- Daily Moisturizers & Creams – Preventative anti‑aging products for all skin types.
- Neck, Hand & Body Care – Comprehensive anti‑aging treatments for multiple areas.
- Professional Aesthetic Skincare – Clinical‑strength products for professional and home use.
- Anhydrous & Oil‑Based Systems – Freeze‑dried powder format available for balms, sticks, and anhydrous serums.
OME service
Packaging & Shipping
Certification
Products Description
Q: What is Matrixyl 3000?
A: Matrixyl 3000 is a branded peptide complex – not a single ingredient, but a precise two‑peptide system developed by Sederma (Croda group). It contains two distinct peptides: Palmitoyl Tripeptide‑1 (Pal‑GHK) and Palmitoyl Tetrapeptide‑7 (Pal‑GQPR). On any INCI‑compliant ingredient label, those are the names you will see listed, not "Matrixyl 3000" itself.
Q: Q2: How does Matrixyl 3000 work?
A: Matrixyl 3000 is a signal peptide complex – it functions as a biological messenger, communicating with skin cells rather than simply sitting on the surface. It mimics the natural distress signal released when collagen breaks down, telling the skin to produce more collagen. The two peptides perform complementary functions: Palmitoyl Tripeptide‑1 stimulates collagen synthesis, while Palmitoyl Tetrapeptide‑7 modulates inflammation.
Q: What is the difference between Matrixyl and Matrixyl 3000?
A: The original Matrixyl contains a single peptide (Palmitoyl Pentapeptide‑4, Pal‑KTTKS). Matrixyl 3000 is the third‑generation version that introduced Palmitoyl Tetrapeptide‑7 alongside Palmitoyl Tripeptide‑1, creating a two‑part system where each peptide performs a complementary and distinct function.
Q: What clinical evidence supports its efficacy?
A:
- 45% decrease in the surface occupied by deep wrinkles (2‑month in‑vivo study)
- 29.4% decrease in the area occupied by deep wrinkles (>200 µm)
- 16% improvement in skin texture and smoothness
- Skin age visibly reduced by 1.8 years after just 4 weeks
- Significant improvement in skin hydration, wrinkle depth reduction of 16.3%
Q: Is Matrixyl 3000 approved for cosmetic use in China?
A: Yes. Both component peptides are listed in China's Inventory of Used Cosmetic Ingredients (IECIC). There is no fixed concentration limit.
Q: Is the product suitable for vegans and vegetarians?
A: Yes. Our Palmitoyl Tripeptide‑1 & Palmitoyl Tetrapeptide‑7 Complex is 100% synthetic, produced via Solid‑Phase Peptide Synthesis (SPPS). No animal‑derived ingredients are used.
Q: What is the solubility of Matrixyl 3000?
A: The standard liquid grade is fully water‑soluble. Freeze‑dried powder is also available for anhydrous and oil‑based formulations.
Q: What are the recommended usage levels?
A:
- Standard 100 ppm solution: 3% – 8% in finished products
- General range: 0.01% – 0.5% active peptide
- Maximum IECIC‑listed use level: No fixed limit
Q: What is the optimal pH range for stability?
A: Matrixyl 3000 is stable across pH 3.0 – 9.0, with optimal stability at pH 5.0 – 7.0.
Q: What ingredients work well with Matrixyl 3000?
A: Matrixyl 3000 works synergistically with:
- Hyaluronic acid – Combined hydration and collagen‑stimulating effects
- Other signal peptides – Multi‑peptide formulations for comprehensive anti‑aging benefits
- Niacinamide (vitamin B3) – Enhanced skin radiance and evenness
- Vitamin C derivatives – Enhanced antioxidant protection
- Ceramides – Enhanced barrier support
Q: What formats are available?
A: We supply multiple grades:
- Standard 100 ppm aqueous‑glycerin solution – the original Sederma formulation reference
- 500 ppm concentrated solution – for low‑MOQ users
- Freeze‑dried peptide complex powder – for anhydrous balm and stick formulations
How To Contact Us?
For bulk inquiries, samples, or custom specifications, please contact our sales team. We look forward to partnering with you for high‑quality Palmitoyl Tripeptide‑1 & Palmitoyl Tetrapeptide‑7 Complex (Matrixyl 3000 / Base Peptide 3000) that meets your exact requirements.
If you need this product for your product lines, please get in touch with us at ella.zhang@huilinbio-tech.com.
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