Xi'an Huilin Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of pentapeptide‑18 powder (leuphasyl) in China. With abundant experience, we are committed to providing high quality natural products with competitive price. Please feel free to wholesale bulk pure pentapeptide‑18 powder (leuphasyl) for sale here from our factory.
What Is Pentapeptide-18?
Pentapeptide-18, commonly known as Leuphasyl in the cosmetic peptide industry, is a synthetic biomimetic neuropeptide composed of five amino acids with the sequence Tyr-D-Ala-Gly-Phe-Leu-OH. It is a modified analog of the endogenous neuropeptide Leu-enkephalin, in which the second-position glycine is replaced with D-alanine – a structural modification that confers enhanced resistance to proteolytic degradation and significantly improves stability in cosmetic formulations.
Developed by Lipotec in Barcelona, Spain, Pentapeptide-18 was introduced as a safer, non-invasive alternative to treatments like botulinum toxin injections. Its mechanism of action is inspired by enkephalins – endogenous neuropeptides that attenuate neural transmission. By binding to enkephalin (opioid) receptors on neuronal membranes, Pentapeptide-18 reduces acetylcholine release via G-protein-mediated calcium channel inhibition, thereby modulating the intensity of facial muscle micro-contractions that drive expression wrinkle formation.
Our Pentapeptide-18 Powder is manufactured through advanced Solid-Phase Peptide Synthesis (SPPS) with rigorous quality control. The result is a consistently pure, stable, and highly bioactive powder that meets the stringent quality requirements of prestige skincare brands worldwide.
Key Features & Advantages
- Neuro-Modulating Mechanism – Mimics endogenous enkephalins to reduce acetylcholine release and soften muscle contractions – a "Botox-like" effect without injection
- High Purity – Available in ≥98% and ≥95% purity (HPLC+MS)
- Enhanced Stability – D-Ala² substitution provides superior resistance to enzymatic degradation vs. natural enkephalins
- Excellent Water Solubility – Soluble in water, glycols, and DMSO; easy to incorporate into aqueous formulations
- Broad pH Stability – Stable at pH 4.0 – 7.5 (optimal pH 5.0 – 7.0)
- Synergistic Potential – When combined with Acetyl Hexapeptide-8 (Argireline), achieves 47% synergistic wrinkle-depth reduction
- Regulatory Compliance – NMPA-approved at ≤1.86% in finished products; EU-compliant
- Clean & Synthetic – 100% synthetic; no animal-derived ingredients; suitable for vegan and clean beauty formulations
- Versatile Formats – Available as lyophilized powder or liquid solution
Technical Specifications (Typical – ≥98% Grade)
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Pentapeptide-18 (Leuphasyl) | - |
| CAS Number | 64963-01-5 | - |
| INCI Name | Pentapeptide-18 | - |
| Synonyms | Leuphasyl; NSC 374895 | - |
| Molecular Formula | C₂₉H₃₉N₅O₇ | - |
| Molecular Weight | 569.6 – 569.7 g/mol | - |
| Sequence | H-Tyr-D-Ala-Gly-Phe-Leu-OH | - |
| Appearance | White to off-white lyophilized powder | Visual |
| Assay (Purity) | ≥98.0% (HPLC) | HPLC |
| Purity (≥95% grade) | ≥95.0% (HPLC+MS) | HPLC + MS |
| Counter-Ion | TFA Salts (Acetate/HCl exchange available) | - |
| Solubility | Soluble in water, glycols, DMSO | - |
| pH Stability Range | 4.0 – 7.5 | - |
| Recommended Storage | 2°C – 8°C (short-term); -20°C (long-term) | - |
| Heavy Metals | Compliant with cosmetic standards | ICP-MS |
| Total Plate Count | ≤1,000 CFU/g | USP <61> |
| Yeast & Mold | ≤100 CFU/g | USP <2021> |
| E. coli | Negative / 10g | USP <2022> |
| Salmonella | Negative / 10g | USP <2022> |
Specifications are for reference. Please request the current COA for batch-specific data.
Pentapeptide 18 Key Skin Benefits
Pentapeptide-18 (leuphasyl peptide) is a scientifically validated neuropeptide with proven anti-wrinkle efficacy. Here are the key benefits supported by research:
Reduces Expression Wrinkles – "Botox-Like" Effect Without Injection
- Pentapeptide-18 acts as a neuromodulator, mimicking natural enkephalins to reduce neuronal excitability and subsequent muscle contraction.
- By binding to enkephalin (opioid) receptors and activating Gi/o-protein signaling, it inhibits voltage-gated calcium channels and reduces acetylcholine release.
- This reduces the intensity of facial muscle micro-contractions that cause expression wrinkles – without the risks or invasiveness of injections.
- When combined with Acetyl Hexapeptide-8 (Argireline), it achieves a 47% synergistic wrinkle-depth reduction.
Targets Dynamic Wrinkles – Forehead, Crow's Feet & Perioral Lines
- Specifically designed to address expression lines caused by repeated facial movements.
- Effective for forehead wrinkles, crow's feet (eye area), and perioral (lip) lines.
- Ideal for "Botox-alternative" skincare formulations.
Distinct Mechanism – Complements Other Neuropeptides
- Pentapeptide-18's mechanism is complementary and distinct from Argireline:
- Argireline blocks SNARE complex assembly (pre-synaptic)
- Leuphasyl activates opioid receptors to reduce acetylcholine release via G-protein-mediated calcium channel inhibition (a different pre-synaptic mechanism)
- This mechanistic complementarity justifies their combination in advanced anti-wrinkle formulations.
Improves Skin Hydration, Elasticity & Texture
- Beyond wrinkle reduction, Pentapeptide-18 simultaneously improves skin hydration, elasticity, and texture.
- Contributes to overall skin rejuvenation and a more youthful appearance.
Clinically Proven & Regulatory Approved
- NMPA-approved at ≤1.86% in finished products.
- EU-compliant under Regulation 1223/2009.
- Approved as a cosmetic ingredient in Japan (JP-CI 2020-038).
- Supported by peer-reviewed research and industry white papers.
Suitable for Sensitive Skin & Clean Beauty
- Synthetic, non-invasive, and well-tolerated.
- No animal-derived ingredients – suitable for vegan and clean beauty formulations.
- Ideal for consumers seeking effective anti-aging solutions without the risks of injectables.
Pentapeptide-18 Applications
- Anti-Wrinkle Serums – Targeted serums for expression lines, forehead wrinkles, and crow's feet.
- Eye Contour Creams – Gentle yet effective formulations for the delicate eye area.
- "Botox-Alternative" Skincare – Premium formulations positioned as non-invasive alternatives to injectables.
- Day & Night Moisturizers – Daily prevention and mild correction of expression lines.
- Face, Neck & Hand Care – Anti-aging treatments for multiple areas.
- Hair Care – Nourishing and strengthening formulations.
- Color Cosmetics (Makeup) – Anti-aging benefits in foundations and primers.
- Lip Area Treatments – Targeted products for perioral lines.
- Cosmeceutical & Aesthetic Post-Care – Home-care products following professional treatments.
Company Introduction
Xi'an Huilin Bio-tech Co., Ltd. is a leading provider of premium plant extracts for health applications. We supply herb extracts, standardized extracts, and fruit/vegetable powders. Dedicated to quality and innovation, we serve global customers in the supplements, food, and cosmetic industries, advancing human health. Click here to learn more.
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FAQ
Q: What is the difference between Pentapeptide-18 and Argireline?
A: Both are neuromodulating peptides with complementary mechanisms:
Argireline blocks SNARE complex assembly to prevent neurotransmitter release.
Leuphasyl activates opioid receptors to reduce acetylcholine release via G‑protein‑mediated calcium channel inhibition.
Combining both achieves a 47% synergistic wrinkle‑depth reduction.
Q: Is the product suitable for vegans and vegetarians?
A: Yes. Our Pentapeptide-18 is 100% synthetic, produced via Solid‑Phase Peptide Synthesis (SPPS). No animal‑derived ingredients are used.
Q: Does it contain allergens?
A: Our Pentapeptide-18 Powder is free from major allergens including gluten, dairy, soy, eggs, fish, shellfish, peanuts, and tree nuts. Allergen declarations are available upon request.
Q: What are the recommended usage levels?
A: Recommended usage varies by application:
- Face serums: 0.01% – 0.03%
- Moisturizers: 0.005% – 0.02%
- Leave‑on products: 0.005% – 0.05%
- General range: 0.01% – 0.5%
- Maximum NMPA‑approved concentration: ≤1.86%
Q: At what stage should Pentapeptide-18 be added to formulations?
A: Add during the cooling phase (below 45°C) at the final stage of formulation to preserve peptide bioactivity.
Q: What ingredients work well with Pentapeptide-18?
A: Pentapeptide-18 works synergistically with:
- Acetyl Hexapeptide-8 (Argireline) – 47% synergistic wrinkle‑depth reduction
- Vitamin C derivatives – Enhanced antioxidant protection
- Other neuromodulating peptides – Complementary mechanisms for advanced anti‑wrinkle formulations
- Palmitoyl Tripeptide-1 – Enhanced skin elasticity improvement
Q: Is Pentapeptide-18 heat‑stable?
A: Pentapeptide-18 should be added during the cooling phase (below 45°C) to avoid thermal degradation. Lyophilized powder should be stored refrigerated (2°C – 8°C).
How To Contact Us?
For bulk inquiries, samples, or custom specifications, please contact our sales team. We look forward to partnering with you for high‑quality Pentapeptide-18 Powder (Leuphasyl) that meets your exact requirements.
If you need this product, please get in touch with us at ella.zhang@huilinbio-tech.com.
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