What is Oligopeptide-1?
Oligopeptide-1 (CAS: 72957-37-0), also known as Tripeptide-1 or GHK (Gly-His-Lys), is a synthetic biomimetic tripeptide composed of three amino acids: glycine, histidine, and lysine. It is a naturally occurring peptide found in human blood, saliva, and urine – at age 20, blood concentration is approximately 200 ng/mL, declining to 80 ng/mL by age 60, a decrease directly associated with reduced tissue regenerative capacity.
Oligopeptide-1 functions as a signal peptide that activates fibroblasts in the dermis to stimulate the production of Type I and Type III collagen, elastin, fibronectin, and laminin. It also promotes the synthesis of hyaluronic acid via HAS2 activity. The peptide naturally binds to divalent copper ions (Cu²⁺) to exert its wound-healing and tissue-repair functions.
Important Regulatory Note: Oligopeptide-1 (GHK) is distinct from Human Oligopeptide-1 (EGF / Epidermal Growth Factor). Oligopeptide-1 (GHK) is a small synthetic tripeptide (MW ~340 Da) and is listed in China's Inventory of Used Cosmetic Ingredients (IECIC). Human Oligopeptide-1 (EGF) is a 53-amino-acid peptide (MW ~6200 Da) and is not permitted as a cosmetic ingredient in China. Our product is Oligopeptide-1 (GHK) – fully compliant for cosmetic use globally, including China.
Our Oligopeptide-1 Powder is manufactured through advanced Solid-Phase Peptide Synthesis (SPPS) with rigorous HPLC purification, ensuring exceptional purity (≥98%), consistent batch-to-batch quality, and high bioactivity.
Key Features & Advantages
- Biomimetic Signal Peptide – Naturally occurring tripeptide (GHK) that signals fibroblasts to produce collagen, elastin, and extracellular matrix components
- High Purity – Available in ≥98% and ≥95% purity (HPLC) with full analytical documentation
- Copper-Binding Capability – Naturally forms complexes with Cu²⁺ ions, enhancing wound healing and tissue repair activity
- Excellent Water Solubility – Fully water-soluble (>50 mg/mL), dissolves quickly at room temperature without heating or co-solvents
- Multi-Pathway Anti-Aging – Stimulates collagen synthesis (48% increase), reduces MMP expression (up to 38% wrinkle depth reduction), and promotes hyaluronic acid production (32% moisture retention improvement)
- Broad pH Stability – Stable at pH 4.0 – 8.0, optimal at pH 5.0 – 7.0
- Non-Irritating & Non-Sensitizing – Well-tolerated; suitable for sensitive skin and post-procedure applications
- Synthetic & Animal-Free – 100% synthetic production; vegan and cruelty-free
- Regulatory Compliant – Listed in IECIC (China); INCI-approved globally
- Versatile Formats – Available as lyophilized powder or liquid solution
Technical Specifications (Typical – ≥98% Grade)
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Oligopeptide-1 (Tripeptide-1 / GHK) | - |
| CAS Number | 72957-37-0 | - |
| INCI Name | Oligopeptide-1 | - |
| Molecular Formula | C₁₄H₂₄N₆O₄ | - |
| Molecular Weight | ~340 g/mol | - |
| Amino Acid Sequence | Gly-His-Lys (GHK) | - |
| Appearance | White to off-white lyophilized powder | Visual |
| Assay (Purity) | ≥98.0% (HPLC) | HPLC |
| Purity (≥95% grade) | ≥95.0% (HPLC) | HPLC |
| Solubility | Fully water-soluble (>50 mg/mL) | - |
| pH Range (1% solution) | 4.0 – 7.0 | - |
| Loss on Drying | ≤5.0% | 105°C |
| Residue on Ignition | ≤1.0% | USP <281> |
| Heavy Metals (as Pb) | ≤10 ppm | ICP-MS |
| Lead (Pb) | ≤2 ppm | ICP-MS |
| Arsenic (As) | ≤2 ppm | ICP-MS |
| Total Plate Count | ≤100 CFU/g | USP <61> |
| Yeast & Mold | ≤10 CFU/g | USP <2021> |
| E. coli | Negative | USP <2022> |
| Salmonella | Negative | USP <2022> |
| Endotoxin Level | <0.1 ng/μg (1 EU/μg) | LAL Test |
Specifications are for reference. Please request the current COA for batch-specific data.
Key Skin Benefits
Oligopeptide-1 (GHK) is one of the most extensively studied signal peptides in skincare, with benefits validated by decades of research. Here are the key highlights:
Stimulates Collagen & Elastin Production
- Oligopeptide-1 activates fibroblasts in the dermis to produce Type I and Type III collagen and elastin.
- As these structural proteins increase, skin firmness improves, wrinkles and fine lines are reduced, and age-related skin thinning is alleviated.
- Studies show up to 48% increase in collagen production and 35% increase in fibroblast activity.
Reduces Wrinkle Depth & Improves Skin Texture
- Downregulates MMP-1 and MMP-3 expression (enzymes that break down collagen).
- Reduces wrinkle depth by up to 38%.
- Enhances skin texture, firmness, and overall youthful appearance.
Accelerates Wound Healing & Tissue Repair
- Promotes the proliferation of keratinocytes and endothelial cells, accelerating skin cell turnover and tissue repair.
- Effectively improves acne scars and repairs skin damaged by UV radiation or external stimuli.
- Supports recovery after laser, peels, and microneedling procedures.
- Strengthens the skin barrier and reduces sensitivity.
Promotes Skin Brightening & Hydration
- Promotes the renewal of aging skin cells, reducing melanin and pigmented cell deposition.
- Stimulates hyaluronic acid synthase-2 (HAS2) activity, improving skin moisture retention by 32%.
- Results in smoother, brighter, and more radiant skin.
Supports Dermal Thickening & Firmness
- Helps strengthen the dermis, making skin thicker and firmer.
- Stimulates fibronectin and laminin production, strengthening the dermal-epidermal junction (DEJ).
- Restores the biomechanical properties of aging skin.
Improves Skin Elasticity & Regeneration
- Promotes dermal fibroblast activity and increases skin elasticity.
- Boosts skin renewal and supports a smoother, healthier skin surface.
- Enhances the healing process and tissue remodeling.
Suitable for Sensitive & Post-Procedure Skin
- Non-irritating and non-sensitizing; well-tolerated even by sensitive skin.
- Widely used in post-procedure skincare to support recovery and regeneration.
- Calms redness and supports barrier recovery on compromised skin.
Applications
- Anti-Aging Serums & Ampoules – High-performance serums targeting wrinkles, fine lines, and loss of firmness.
- Post-Procedure Repair Formulations – Products for use after laser, chemical peels, microneedling, and other aesthetic treatments.
- Eye Contour Creams & Serums – Gentle yet effective formulations for the delicate eye area.
- Acne Scar & Blemish Treatments – Formulations targeting post-inflammatory hyperpigmentation and scar improvement.
- Daily Moisturizers & Creams – Preventative anti-aging products for users in their late 20s to 30s.
- Neck & Décolleté Creams – Combined with firming peptides for comprehensive rejuvenation.
- Hair Care Products – Nourishing and scalp-repairing formulations.
- Medical-Grade Skincare – Clinical-strength products for professional and home use.
OME service
Packaging & Shipping
Certification
FAQ
Q: What is the difference between Oligopeptide-1 and EGF (Epidermal Growth Factor)?
A: Oligopeptide-1 (INCI) is a synthetic tripeptide (GHK) composed of glycine, histidine, and lysine with a molecular weight of ~340 Da. EGF (Human Oligopeptide-1) is a 53-amino-acid peptide with a molecular weight of ~6200 Da. They are completely different substances. In China, Oligopeptide-1 (GHK) is permitted for cosmetic use; EGF is not permitted. Our product is Oligopeptide-1 (GHK) – fully compliant.
Q: Is Oligopeptide-1 (GHK) safe for cosmetic use?
A: Yes. Oligopeptide-1 is generally considered safe when used in cosmetic formulations. It is listed in China's IECIC and is widely used globally. It is non-irritating, non-sensitizing, and suitable for sensitive skin.
Q: Does Oligopeptide-1 contain animal-derived ingredients?
A: No. Our Oligopeptide-1 is 100% synthetic, produced via Solid-Phase Peptide Synthesis (SPPS). No animal-derived ingredients are used. It is suitable for vegan and cruelty-free formulations.
Q: Does it contain allergens?
A: Our Oligopeptide-1 Powder is free from major allergens including gluten, dairy, soy, eggs, fish, shellfish, peanuts, and tree nuts. Allergen declarations are available upon request.
Q: What is the solubility of Oligopeptide-1?
A: Oligopeptide-1 is fully water-soluble (>50 mg/mL) and dissolves quickly at room temperature without heating or co-solvents. It is insoluble in oils.
Q: What are the recommended usage levels?
A: Recommended usage varies by application:
- Anti-aging serums: 0.001% – 0.01%
- Leave-on products: 2 – 10 ppm
- General range: 0.01% – 0.1% (0.05% – 0.1% for pronounced efficacy)
- Post-procedure formulations: As per formulation requirements
Q: At what stage should Oligopeptide-1 be added to formulations?
A: Add during the cooling phase (below 40°C) at the final stage of formulation to preserve peptide bioactivity.
Q: What is the optimal pH range for stability?
A: Oligopeptide-1 is stable at pH 4.0 – 8.0, with optimal stability at pH 5.0 – 7.0.
Q: What ingredients work well with Oligopeptide-1?
A: Oligopeptide-1 works synergistically with:
- Copper peptides – Natural copper-binding enhances wound-healing activity
- Other signal peptides – Multi-peptide formulations for comprehensive anti-aging benefits
- Hyaluronic acid – Combined hydration and collagen-stimulating effects
- Vitamin C derivatives – Enhanced antioxidant protection
Q: Is Oligopeptide-1 suitable for post-procedure skincare?
A: Yes. Oligopeptide-1 is widely used in post-procedure skincare due to its ability to support skin recovery, regeneration, and barrier repair.
Q: Is Oligopeptide-1 heat-stable?
A: Oligopeptide-1 should be added during the cooling phase (below 40°C) to avoid thermal degradation. Lyophilized powder should be stored refrigerated (2°C – 8°C).
Q: How should Oligopeptide-1 Powder be stored?
A: Store at 2°C – 8°C (refrigerated) for short-term storage. For long-term storage (months to years), keep at -20°C. Protect from light and moisture. Under these conditions, the product maintains quality for 24 months.
Q: What is the difference between Oligopeptide-1 and Tripeptide-1?
A: Oligopeptide-1 and Tripeptide-1 refer to the same ingredient. Tripeptide-1 is the chemical name (referring to its three amino acids: Gly-His-Lys), while Oligopeptide-1 is the INCI name. Both terms are used interchangeably in the cosmetic industry.
How To Contact Us?
For bulk inquiries, samples, or custom specifications, please contact our sales team. We look forward to partnering with you for high‑quality Oligopeptide-1 Powder that meets your exact requirements.
If you need this product for your product lines, please get in touch with us at ella.zhang@huilinbio-tech.com.
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