Product Description
Myristoyl Hexapeptide-23 (also known as SymPeptide 380) is a synthetic biomimetic lipopeptide with the amino acid sequence Myristoyl-Ala-Lys-Lys-Leu-Lys-Leu-NH₂ (Myr-AKKLKL). It consists of six amino acids (alanine, lysine, and leucine) with a myristoyl fatty acid chain attached to the N-terminus.
Myristoyl Hexapeptide-23 is designed to mimic naturally occurring antimicrobial peptides found in human skin. The myristoyl modification significantly enhances lipophilicity, allowing the peptide to interact effectively with bacterial cell membranes and penetrate the skin's lipid barrier. This unique structure enables the peptide to bind to the cell membranes of Propionibacterium acnes (also known as Cutibacterium acnes) – the primary bacteria responsible for acne – and disrupt the membrane, leading to bacterial cell death.
Beyond its antimicrobial action, Myristoyl Hexapeptide-23 functions as a signal peptide that stimulates fibroblast activity and promotes collagen synthesis, making it a dual-action ingredient that simultaneously addresses acne and signs of aging. This combination is particularly valuable for adult acne and post-acne skin concerns, where both breakouts and wrinkles need to be addressed.
Our Myristoyl Hexapeptide-23 Powder is manufactured through advanced Solid-Phase Peptide Synthesis (SPPS) followed by N-terminal myristoylation and rigorous HPLC purification. The result is a consistently pure (≥95%–98%), stable, and highly bioactive powder that meets the stringent quality requirements of prestige skincare brands worldwide.
Key Features & Advantages
- Dual-Action Mechanism – Combines broad-spectrum antibacterial activity against acne-causing bacteria with collagen-stimulating, anti-aging benefits – a rare and valuable profile in a single peptide
- Broad-Spectrum Antibacterial – Effectively inhibits Propionibacterium acnes (the primary cause of acne) and other acne-causing bacteria
- Signal Peptide Activity – Falls under the category of signal peptides designed to mimic the body's natural peptides that regulate cellular activities related to aging and skin repair
- Collagen Stimulation – Stimulates fibroblast activity, leading to increased collagen synthesis for improved skin elasticity and firmness
- Enhanced Skin Penetration – Myristoyl fatty acid chain enhances lipophilicity, allowing better interaction with lipid membranes and deeper skin absorption
- High Purity – Available in ≥95% and ≥98% purity (HPLC) with full analytical documentation
- Excellent Water Solubility – Water-soluble white powder format; easy to incorporate into aqueous and emulsion formulations
- Synthetic & Animal-Free – 100% synthetic production via SPPS; vegan and cruelty-free
- Regulatory Compliant – Listed in CosIng (EU) and China IECIC; permitted for cosmetic use
Technical Specifications (Typical – ≥98% Grade)
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Myristoyl Hexapeptide-23 | - |
| CAS Number | Not publicly assigned | - |
| INCI Name | Myristoyl Hexapeptide-23 | - |
| Synonyms | SymPeptide 380; Antimicrobial Peptide | - |
| Amino Acid Sequence | Myristoyl-Ala-Lys-Lys-Leu-Lys-Leu-NH₂ (Myr-AKKLKL) | - |
| Molecular Formula | C₄₇H₉₂N₁₀O₇ | - |
| Molecular Weight | 909.3 g/mol | - |
| Appearance | White to off-white powder | Visual |
| Assay (Purity) | ≥98.0% (HPLC) | HPLC |
| Purity (≥95% grade) | ≥95.0% (HPLC) | HPLC |
| Solubility | Water-soluble | - |
| Loss on Drying | ≤5.0% | 105°C |
| Heavy Metals | No heavy metals | ICP-MS |
| Total Plate Count | ≤100 CFU/g | USP <61> |
| Yeast & Mold | ≤10 CFU/g | USP <2021> |
| E. coli | Negative | USP <2022> |
| Salmonella | Negative | USP <2022> |
| Skin/Eye Irritation | None reported | - |
Specifications are for reference. Please request the current COA for batch-specific data.
Key Skin Benefits
Myristoyl Hexapeptide-23 is a scientifically validated dual-action peptide with proven antibacterial and anti-aging benefits. Here are the key highlights:
1. Kills Acne-Causing Bacteria – The Root Cause of Breakouts
- Myristoyl Hexapeptide-23 exhibits broad-spectrum antibacterial properties and effectively inhibits Propionibacterium acnes – the primary bacteria responsible for acne.
- It works by binding to bacterial cell membranes and disrupting their structure, leading to bacterial cell death.
- By eliminating acne-causing bacteria, it helps prevent further skin problems and breakouts.
2. Reduces Inflammation & Calms Acne-Prone Skin
- The peptide has anti-inflammatory properties that help soothe irritated, inflamed skin.
- Reduces redness and swelling associated with active acne lesions.
- Supports skin barrier function for healthier, more resilient skin.
3. Stimulates Collagen Production – Fights Signs of Aging
- As a signal peptide, Myristoyl Hexapeptide-23 stimulates fibroblast activity, leading to increased collagen synthesis.
- Promotes skin firmness, elasticity, and structural integrity.
- Helps reduce the appearance of fine lines and wrinkles.
4. Improves Skin Firmness & Elasticity
- By promoting collagen production and enhancing dermal matrix components, the peptide improves skin firmness and elasticity.
- Helps combat skin sagging and loss of elasticity.
5. Delivers Anti-Wrinkle & Anti-Aging Benefits
- Clinical studies show statistically significant improvements in visual facial photoaging, solar elastosis, and collagen stimulation over 12 weeks of use.
- 3D image analysis has demonstrated a 31% reduction in deep wrinkle volume.
- Widely used in anti-aging skincare products to reduce fine lines and wrinkles.
6. Controls Excess Oil & Prevents Future Breakouts
- Supports significant sebum control, making it particularly effective for oily and combination skin types.
- Helps prevent the formation of new comedones (blackheads and whiteheads).
- Especially suitable for various oil control, acne removal, and acne products.
7. Supports Skin Repair & Regeneration
- Enhances skin texture and promotes a smoother, healthier skin surface.
- Supports the skin's natural repair mechanisms.
- Suitable for post-acne scar improvement and overall skin renewal.
8. Suitable for All Skin Types – Including Sensitive
- Non-irritating and non-sensitizing; no skin or eye irritation reported.
- No heavy metals; safe for regular use.
- Ideal for sensitive skin that cannot tolerate harsher acne treatments like benzoyl peroxide or salicylic acid.
Applications
- Anti-Acne & Spot Treatments – Targeted serums, gels, and creams for active breakouts, cystic acne, and comedones.
- Oil-Control Toners & Serums – Lightweight formulations for oily and combination skin types.
- Anti-Aging & Firming Creams – Products targeting both acne and signs of aging (adult acne formulations).
- Post-Acne Repair Formulations – Products for scar improvement, post-inflammatory hyperpigmentation, and skin renewal.
- Daily Moisturizers – Preventative skincare for acne-prone and aging skin.
- Professional Aesthetic Skincare – Clinical-strength products for professional and home use.
- Post-Procedure Soothing Formulations – Calming and repairing products for skin after aesthetic treatments.
- Body Care – Acne treatments for the chest and back (body acne).
Frequently Asked Questions (FAQ)
Q: What is the difference between Myristoyl Hexapeptide-23 and Hexapeptide-23?
A: Myristoyl Hexapeptide-23 is the myristoylated (lipidated) derivative of Hexapeptide-23. The myristoyl fatty acid chain significantly enhances lipophilicity, allowing the peptide to interact effectively with bacterial cell membranes and penetrate the skin's lipid barrier. Hexapeptide-23 (the bare peptide form) functions primarily as a skin conditioning agent, while the myristoylated derivative also has antimicrobial properties.
Q: What are the recommended usage levels?
A: Recommended usage varies by application:
- Anti-acne serums and creams: 0.5% – 2%
- General leave-on products: 0.1% – 0.5%
- Oil-control toners: 0.1% – 0.3%
- Concentrated active formulations: Up to 5%
Q: What is the optimal pH range for stability?
A: Myristoyl Hexapeptide-23 is stable across a broad pH range of 4.0 – 7.5, making it compatible with most cosmetic formulations. Optimal efficacy is usually observed at physiological pH (around 7.4).
Q: At what stage should Myristoyl Hexapeptide-23 be added to formulations?
A: Add during the cooling phase (below 45°C) at the final stage of formulation to preserve peptide bioactivity.
Q: What ingredients work well with Myristoyl Hexapeptide-23?
A: Myristoyl Hexapeptide-23 works synergistically with:
- Salicylic acid – Enhanced pore-clearing and anti-acne action
- Niacinamide – Soothing and barrier-supporting benefits
- Hyaluronic acid – Hydration and skin repair
- Other antibacterial peptides – Comprehensive anti-acne formulations
- Retinol derivatives – Combined anti-acne and anti-aging benefits
Q: What should be avoided when formulating?
A: Avoid strongly acidic (pH <3) or strongly alkaline (pH >9) conditions, as this may affect peptide stability.
Q: Is Myristoyl Hexapeptide-23 heat-stable?
A: Myristoyl Hexapeptide-23 should be added during the cooling phase (below 45°C) to avoid thermal degradation. Lyophilized powder should be stored refrigerated (2°C – 8°C).
Q: Is Myristoyl Hexapeptide-23 safe for cosmetic use?
A: Yes. Myristoyl Hexapeptide-23 is listed in CosIng (EU COSING Ref No: 85277) and is permitted for cosmetic use. It functions as a skin conditioning agent. No skin or eye irritation has been reported.
Q: Is Myristoyl Hexapeptide-23 approved for use in cosmetics globally?
A: Yes:
- EU: Listed in CosIng (COSING Ref No: 85277); compliant with Regulation 1223/2009
- China: Permitted cosmetic ingredient
- Global: Widely used in cosmetic formulations across major markets
Company Introduction
Xi'an Huilin Bio-tech Co., Ltd. is a leading provider of premium plant extracts for health applications. We supply herb extracts, standardized extracts, and fruit/vegetable powders. Dedicated to quality and innovation, we serve global customers in the supplements, food, and cosmetic industries, advancing human health. Click here to learn more.
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How To Contact Us?
For bulk inquiries, samples, or custom specifications, please contact our sales team. We look forward to partnering with you for high‑quality Myristoyl Hexapeptide-23 Powder that meets your exact requirements.
If you need this product for your product lines, please get in touch with us at ella.zhang@huilinbio-tech.com.
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