Introduction
Dihydromyricetin (DHM), also known as Ampelopsin, is a natural flavonoid compound abundantly found in vine tea (Ampelopsis grossedentata) – a medicinal and edible plant that has been used in China for hundreds of years. As the primary bioactive constituent of vine tea, DHM has garnered significant scientific attention for its remarkable antioxidant, anti-inflammatory, hepatoprotective, and anti-aging properties.
Our Dihydromyricetin Powder is manufactured through advanced extraction and purification processes from high-quality, non-GMO vine tea (Ampelopsis grossedentata) leaves. The result is a consistently pure, stable, and bioavailable powder (≥98% purity by HPLC) that meets the stringent quality requirements of nutraceutical, cosmetic, and pharmaceutical applications.
Dihydromyricetin's unique molecular structure – featuring a flavanonol backbone with multiple hydroxyl groups – confers exceptional free radical scavenging capacity and the ability to modulate key cellular signalling pathways, including NF-κB, AMPK, and Nrf2. This makes it a versatile ingredient for products targeting oxidative stress, inflammation, metabolic health, and skin longevity.
Key Features & Advantages
- High Purity – ≥98.0% purity by HPLC (typical batches), with 98%, 95%, and 90% grades available.
- Potent Antioxidant Activity – Powerful free radical scavenger with multiple pharmacological properties including anti-inflammatory, anticancer, and antimicrobial effects.
- Multiple Pathway Modulation – Acts through AMPK, NF-κB, Nrf2, and PI3K/Akt pathways, affecting autophagy, glucose transport, and inflammation.
- Excellent Bioactivity – Proven efficacy in both oral supplementation and topical application.
- Clean & Natural – Derived from vine tea (Ampelopsis grossedentata), a traditional medicinal plant with centuries of safe use.
- Versatile Applications – Suitable for dietary supplements, functional foods, cosmetics, and pharmaceutical intermediates.
- Sustainable Sourcing – Manufactured from sustainably cultivated vine tea with full supply chain traceability.
- Regulatory Compliance – Meets international quality standards for food, supplement, and cosmetic ingredients.
Technical Specifications (Typical – 98% Grade)
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Dihydromyricetin (DHM / Ampelopsin) | - |
| CAS Number | 27200-12-0 | - |
| Molecular Formula | C₁₅H₁₂O₈ | - |
| Molecular Weight | 320.25 – 320.26 g/mol | - |
| Appearance | White to off-white to light yellow crystalline powder | Visual |
| Assay (Purity) | ≥98.0% (HPLC) | HPLC |
| Melting Point | ~248°C | USP <741> |
| Specific Rotation | +15.5 to +17.0° (C=0.9, methanol) | - |
| Loss on Drying | ≤1.0% | 105°C, 3h |
| Heavy Metals | ≤10 ppm | ICP-MS |
| Total Plate Count | ≤1,000 CFU/g | USP <61> |
| Yeast & Mold | ≤100 CFU/g | USP <2021> |
| E. coli | Negative / 10g | USP <2022> |
| Salmonella | Negative / 10g | USP <2022> |
| Solubility | Soluble in DMSO, DMF, ethanol; poorly soluble in water | - |
| Particle Size | 95% pass 80 mesh (customisable) | Sieve Analysis |
Specifications are for reference. Please request the current COA for batch-specific data.
Key Health & Skin Benefits
Dihydromyricetin is one of the most extensively studied natural flavonoids, with benefits supported by clinical trials and peer-reviewed research. Here are the key highlights:
Powerful Antioxidant & Anti‑Inflammatory Defence
- DHM is a potent free radical scavenger with strong antioxidative properties.
- It suppresses inflammation by inhibiting key pathways including NF-κB, MAPK, and NLRP3 inflammasome activation.
- Studies show DHM reduces pro‑inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8) and oxidative stress markers.
Reverses Skin Aging at the Epigenetic Level
- DHM is an epigenetic inhibitor that targets age‑related DNA hypermethylation, rejuvenating skin cells and reactivating youth‑associated genes.
- In a clinical study of 60 participants across diverse ethnicities, topical DHM significantly reduced epidermal DNA methylation age and improved skin roughness, wrinkle visibility, and dermal structure after 8 weeks of use.
- Animal studies confirm DHM enhances skin elasticity and preserves collagen levels – in one study, DHM promoted skin cell proliferation by approximately 1.5‑fold.
- DHM acts as a RAGE inhibitor (binding affinity KD = 28.7 μM), suppressing glycation‑induced skin aging.
Protects Liver & Supports Metabolic Health
- A randomised controlled trial in NAFLD patients showed that DHM supplementation (150 mg twice daily for 3 months) improved glucose and lipid metabolism and exerted significant anti‑inflammatory effects.
- DHM improves insulin resistance and decreases serum levels of TNF‑α.
- In a double‑blind, placebo‑controlled trial, 6‑12 months of DHM use resulted in liver enzyme normalisation (35% vs. 5%) and improvements in diabetes and lipid parameters in MASLD patients.
- DHM accelerates alcohol metabolism by enhancing alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity.
Dual‑Action Anti‑Acne Effects
- DHM exhibits potent bactericidal activity against Propionibacterium acnes with a minimum inhibitory concentration of 0.5 mg/mL.
- It suppresses host inflammatory responses by inhibiting TLR2/NF‑κB/MAPK pathways, reducing pro‑inflammatory cytokines (IL‑1β, TNF‑α, IL‑8).
- In a murine acne model, topical 0.1% DHM gel attenuated ear edema, decreased inflammatory cell infiltration, and reduced bacterial loads comparable to standard treatments (adapalene and clindamycin).
Supports Cardiovascular Health
- DHM suppresses endothelial NLRP3 inflammasome activation and attenuates atherogenesis by promoting mitophagy.
- It exhibits unique vasoprotective effects, including both inhibition of platelet activation and reduction of fibrin generation as a result of endothelial protection.
- DHM protects vascular smooth muscle cells against oxidative injury and apoptosis.
Neuroprotective & Cognitive Support
- DHM enhances cognitive functions and shows potential in reversing age‑related cognitive decline by modulating inflammatory pathways and oxidative stress responses.
- It exerts a more rapid antidepressant‑like effect than typical antidepressants through inhibition of neuroinflammation.
- DHM protects against mitochondrial dysfunction in neuronal cells.
Promotes Wound Healing & Tissue Repair
- Studies show DHM accelerates the wound healing process.
- Local intradermal injection of DHM (50 μM) has been shown to reduce scar area, cross‑sectional area, and scar elevation index.
Supports Gut Health & Microbiome
- Dietary DHM supplementation enhances antioxidant capacity, modulates jejunal barrier function, and remodels cecal microbiota.
- It improves hepatic redox status and supports a less pro‑inflammatory cytokine profile.
What is Dihydromyricetin Used For?
- Dietary Supplements & Nutraceuticals – Capsules, tablets, and powders for liver support, metabolic health, antioxidant defence, and cognitive wellness.
- Anti‑Aging Skincare & Cosmetics – Serums, creams, and lotions for epigenetic skin rejuvenation, wrinkle reduction, and photoprotection.
- Functional Foods & Beverages – Fortified drinks, beauty foods, health jellies, and sports nutrition products.
- Pharmaceuticals – Active pharmaceutical ingredients and intermediates for liver protection and anti‑inflammatory applications.
- Acne & Skin Repair Products – Topical gels and creams for acne treatment and scar reduction.
- Sports Nutrition – Formulations for recovery, antioxidant support, and metabolic optimisation.
- Animal Nutrition – Feed additive for livestock and aquaculture to support antioxidant status and liver health.
Frequently Asked Questions (FAQ)
Q: What is Dihydromyricetin (DHM)?
A: Dihydromyricetin (DHM), also known as Ampelopsin, is a natural flavonoid compound primarily extracted from vine tea (Ampelopsis grossedentata). It is the main bioactive constituent responsible for vine tea's numerous health benefits, including antioxidant, anti‑inflammatory, hepatoprotective, and anti‑aging properties.
Q: What purity grades are available?
A: We offer Dihydromyricetin Powder in ≥98.0% purity (HPLC) as standard. Other grades including 95% and 90% are available upon request.
Q: Is the product suitable for vegans and vegetarians?
A: Yes. Our Dihydromyricetin Powder is derived from vine tea (Ampelopsis grossedentata) using food‑grade extraction processes. No animal‑derived ingredients are used.
Q: Does it contain allergens?
A: Our Dihydromyricetin Powder is free from major allergens including gluten, dairy, soy, eggs, fish, shellfish, peanuts, and tree nuts. Allergen declarations are available upon request.
Q: What is the solubility of Dihydromyricetin?
A: DHM is soluble in DMSO (2 mg/mL), DMF, and ethanol, but has poor solubility in water. For aqueous formulations, we recommend using advanced delivery systems such as nanoliposomes or inclusion complexes.
Q: What are the recommended usage levels?
A: Typical usage varies by application:
- Dietary supplements: 150–600 mg per day (clinical studies used 150 mg twice daily for NAFLD)
- Functional beverages: As per formulation requirements
- Skincare (topical): 0.1%–2% in serums and creams
- Acne treatments: 0.1% DHM gel
Q: Is DHM suitable for oral and topical applications?
A: Yes. DHM has demonstrated efficacy in both oral supplementation (for metabolic health, liver protection, and systemic antioxidant support) and topical application (for anti‑aging, acne treatment, and skin repair).
Q: What ingredients work well with Dihydromyricetin?
A: DHM works synergistically with other antioxidants and anti‑inflammatory actives. For skincare, it pairs well with vitamin C, niacinamide, and soothing botanicals. For supplements, it complements milk thistle, N‑acetylcysteine, and other liver‑support ingredients.
Q: Is DHM stable in finished formulations?
A: DHM should be protected from light and excessive heat. In aqueous formulations, we recommend using stabilisation technologies such as nanoliposomes or cyclodextrin inclusion complexes to improve stability and bioavailability.
Q: What quality standards does your Dihydromyricetin Powder meet?
A: Our product meets rigorous international quality standards for food, supplement, and cosmetic ingredients. Each batch is tested for purity (HPLC), heavy metals, microbiology, and physical properties.
Q: What certifications do you hold?
A: We hold cGMP, ISO 9001, ISO 22000, HACCP, and FDA‑registration. Copies of our certificates are available upon request.
Q: Do you provide a Certificate of Analysis (COA) with each shipment?
A: Yes. Every shipment includes a detailed COA showing all test results for the specific batch. Additional documents such as MSDS, TDS, stability data, and formulation guides are also available.
Q: Is Dihydromyricetin approved for use in food and supplements?
A: DHM is widely used as a dietary supplement ingredient and functional food component. Vine tea (Ampelopsis grossedentata) has a long history of safe use as a medicinal and edible plant in China. Please consult with your regulatory team for specific market requirements in your region.
Q: What is the minimum order quantity (MOQ)?
A: Our standard MOQ is 1 kg, making it suitable for R&D, product trials, and small‑batch production. Commercial bulk orders receive competitive pricing.
Q: Can I request a sample before placing a bulk order?
A: Yes. We offer samples (typically 10–50 g) for quality evaluation and formulation development.
Q: How should Dihydromyricetin Powder be stored?
A: Store in a cool, dry place, protected from light. Keep containers tightly sealed when not in use. Under these conditions, the product maintains quality for 24 months from the date of manufacture.
Q: Do you offer custom packaging or private label services?
A: Yes. We work with partners on custom packaging, private labelling, and OEM/ODM projects. Please provide your specifications and we will tailor our service accordingly.
Why Choose Huilin Bio-Tech?
Your Professional Manufacturing & Sourcing Partner
We are more than a supplier - we are a comprehensive supply chain partner dedicated to high-quality ingredients, custom formulations, and finished products across multiple industries.
Professional Manufacturer: Xi'an Huilin Bio-tech Co., Ltd. is a high-tech biotechnology company specializing in the production, R&D, and export of natural botanical extracts.
Quality Assurance: Every batch undergoes rigorous testing for capsaicin content (HPLC), heavy metals (ICP-MS), and microbiological purity to ensure consistent quality and safety.
Flexible Specifications: We offer a wide range of specifications from 1% to 98% capsaicin content to meet diverse application requirements.
Customization Capabilities: We offer flexible packaging options and custom formulations to meet diverse customer requirements.
Supply Chain Reliability: With established supply chains and robust production capacity, we ensure timely delivery and stable supply for bulk orders.
Technical Support: Our experienced R&D team provides formulation guidance and technical support throughout your product development process.
Global Compliance: Products are manufactured in compliance with international quality standards and regulatory requirements.
For inquiries, quotations, or sample requests, please contact: sales@huilinbio-tech.com
References
1. Dihydromyricetin May Attenuate Skin Aging as a RAGE Inhibitor. Nutrients. 2025;17(11):1862. doi:10.3390/nu17111862.
🔗 View full text: https://www.mdpi.com/2072-6643/17/11/1862
(DHM significantly alleviated skin aging in rats, enhanced skin elasticity, preserved collagen levels, and promoted cell proliferation. DHM acts as a RAGE inhibitor with binding affinity KD = 28.7 μM.)
2. Epigenetic Skin Aging and Its Reversal to Improve Skin Longevity across Ethnicities and Phototypes Using a Dihydromyricetin‑Containing Serum: Results from a Prospective, Single‑Cohort Study. Dermatology and Therapy. 2026;16:3049–3064. doi:10.1007/s13555-026-01764-4.
🔗 View full text: https://link.springer.com/article/10.1007/s13555-026-01764-4
(Clinical study of 60 participants across Fitzpatrick phototypes I–VI. Topical DHM significantly reduced epidermal DNA methylation age and improved skin roughness, wrinkle visibility, and dermal echogenicity after 8 weeks.)
3. Dihydromyricetin exerts dual anti‑acne actions by suppressing propionibacterium acnes proliferation and host inflammatory responses via TLR2/NF‑κB/MAPK pathway inhibition. European Journal of Pharmacology. 2025.
🔗 View full text: https://www.sciencedirect.com/science/article/abs/pii/S001429992500915X
(DHM exhibited potent bactericidal activity against P. acnes (MIC = 0.5 mg/mL). Topical 0.1% DHM gel attenuated ear edema and reduced bacterial loads comparable to standard treatments.)
4. Chen S, Zhao X, Wan J, et al. Dihydromyricetin improves glucose and lipid metabolism and exerts anti‑inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial. Pharmacological Research. 2015.
🔗 View full text: https://pubmed.ncbi.nlm.nih.gov/26032587/
(RCT in 60 NAFLD patients: DHM 150 mg twice daily for 3 months significantly improved glucose and lipid metabolism and exerted anti‑inflammatory effects.)
5. Dietary supplement based on dihydromyricetin in metabolic dysfunction‑associated steatotic liver disease: a double‑blind, placebo‑controlled, randomized clinical trial. Annals of Gastroenterology. 2026.
🔗 View full text: https://pubmed.ncbi.nlm.nih.gov/41612982/
(6‑12 months of DHM use resulted in liver enzyme normalisation (35% vs. 5%) and improvements in diabetes and lipid parameters in MASLD patient
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