Palmitoyl Pentapeptide -4

Product Introduction

Palmitoyl pentapeptide -4 is a small molecular polypeptide formed by linking collagen Ⅰ fragments with Palmitic Acid through amide bond, and its peptide sequence is Pal-Lys-Thr-Thr-Lys-Ser-OH (referred to as Pal-KTTKS for short, Pal refers to palmitoyl, Lys refers to lysine, Thr refers to threonine and Ser refers to serine).
Palmitoyl pentapeptide -4(Pal-KTTKS) can effectively promote the proliferation of collagen, hyaluronic acid (hyaluronic acid) and elastic fibers (Pal-KTTKS enters the skin and is hydrolyzed into alkyl chains and KTTKS by aminopeptidase in the skin, and the released KTTKS upregulates epidermal growth factor TGF-β, which stimulates fibroblasts to transcribe more collagen), increases skin moisture content, and increases skin thickness. If palmitoyl pentapeptide -4 is added to the culture dish of fibroblasts, the synthesis ability of collagen ⅰ, ⅲ, ⅳ and fibronectin can be enhanced.

Basic information

The role of palmitoyl pentapeptide -4

Palmitoyl pentapeptide -4, as one of the earliest signal peptides used in skin care products, has a clear anti-aging effect, which can effectively improve skin roughness, reduce the number of fine lines, reduce the depth and area of wrinkles, etc., and has the characteristics of mild and non-irritating. There are a lot of basic research and literature to prove its efficacy.
1. Palmitoyl pentapeptide -4 can penetrate the dermis to increase collagen, and reverse the process of skin aging through reconstruction from the inside out.
2. Palmitoyl Pentapeptide -4 is actually a C- terminal fragment of collagen I, which has the effect similar to laser surgery.
3. Stimulate the proliferation of collagen, elastic fiber and hyaluronic acid, improve the water content and water locking degree of skin, increase skin thickness and reduce fine lines.
4. can increase the absorption effect.

Principle and mechanism of palmitoyl pentapeptide -4

Palmitoyl pentapeptide -4 can repair and reconstruct extracellular matrix and epidermis-dermis junction (DEJ) by promoting the production of extracellular matrix elastin, fibronectin and glycosaminoglycan collagen (especially type I, III and IV collagen), thus achieving anti-aging effect. Elastin, fibronectin and collagen keep the skin structure stable and prevent wrinkles. Other extracellular matrices maintain the microenvironment of tissues and cells, delay cell aging and maintain skin moisture.
The structure of palmitoyl pentapeptide -4 collagen is related to the precursor of type I collagen, which is a fragment of collagen structure and mainly increases the type I and type III collagen in tissues through biosynthesis.

Separation method of palmitoyl pentapeptide -4

A method for separating palmitoyl pentapeptide 4 belongs to the technical field of polypeptide separation, and specifically comprises the following steps: 1) placing crude palmitoyl pentapeptide 4 in dichloromethane/methanol mixed water solution for microwave pretreatment and filtering; 2) separation and purification by gel permeation chromatography; 3) twice reversed-phase high performance liquid chromatography separation and purification; And 4) freeze drying to obtain the high-purity palmitoyl pentapeptide 4. By the method, the crude palmitoyl pentapeptide 4 obtained by solid-phase synthesis is separated and purified, and the separation speed is high, the sensitivity is high, and the resolution is strong; most side reaction products, organic solvents and the like in the crude peptide can be removed to obtain high-purity palmitoyl pentapeptide 4, and the separation and purification efficiency is high.

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Contact information

Please contact us at ella.zhang@huilinbio-tech.com.

why choose us?

• We abide by all relevant industry standards and regulations to ensure the safety and quality of our products.
• We insist on innovation and learning to promote the transformation and upgrading of enterprises.
• We are a factory in China, providing high-quality Palmitoyl pentapeptide -4 products and professional services. Companies adhering to the "integrity, dedication, innovation and development" concept, all staff unite as one.
• We attach importance to customer feedback and use it to continuously improve our products and services.
• Our factory is committed to providing quality products. We adopt strict quality control standards to ensure the purity of raw materials and the safety of products. We adopt advanced production technology and equipment to ensure the stability and consistency of products.
• Our products have been strictly tested and verified, and meet the international food hygiene standards.
• We have an experienced research team dedicated to the research and development of Palmitoyl pentapeptide -4. They cooperate with many scientific research institutions and universities to innovate and improve constantly to keep their products competitive in the market. We pay attention to the latest scientific research progress and technical trends to ensure the quality and effect of products.
• We provide customized services, and adjust the packaging, specifications and formula according to the needs of customers. We can provide personalized solutions and work closely with customers to ensure that our products meet their expectations and requirements.
• We have a good reputation and reputation. We are guided by customer satisfaction, adhering to the principle of honest management and service concept. Our team always treats customers with a professional, efficient and friendly attitude and answers their questions and needs on time.

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