Introduction to Bilirubin
Bilirubin is the principal pigment of bile and one of the major end products of hemoglobin decomposition. It is a tetrapyrrole compound containing conjugated double bonds and reactive hydrogen atoms.
Historically considered a metabolic waste product due to its pathological accumulation in conditions such as neonatal jaundice, bilirubin has been increasingly recognized for its beneficial physiological roles. It is a prominent endogenous antioxidant cytoprotectant with potent antioxidant activity, protecting lipids, proteins, and other biomolecules from oxidative stress. Bilirubin also exhibits anti-inflammatory, immunomodulatory, cytoprotective, and neuroprotective functions. Moderate serum bilirubin levels are associated with reduced risks of cardiovascular and metabolic diseases.
Bilirubin is the primary active compound in Calculus bovis (artificial bezoar / Niuhuang), a traditional Chinese medicine with significant market value. It is also widely used in diagnostic applications, including in vitro diagnostic (IVD) reagents for serum bilirubin determination in liver function tests, jaundice detection, and other clinical diagnostics.
Certificate of Analysis (COA)
| Parameter | Specification | Typical Result |
|---|---|---|
| Appearance | Orange to red to brown powder | Complies |
| Assay (HPLC) | ≥98.0% | 98.5% |
| Identification (HPLC) | Retention time matches standard | Complies |
| Water Content (K.F.) | ≤1.0% | 0.6% |
| Residue on Ignition | ≤0.2% | 0.1% |
| Heavy Metals | ≤20 ppm | Complies |
| Lambda Max | 450–454 nm (in CHCl₃) | 452 nm |
| Molar Absorption Coefficient | ≥59,600 L/(mol·cm) | Complies |
| Infrared Spectrum | Conforms to reference | Complies |
| Particle Size | As per customer specifications | D90 ≤180 µm |
| Microbial Limits | TAMC ≤1000 cfu/g; absence of pathogens | Complies |
Note: Batch-specific COA is available upon request.
Bilirubin benefits
- Principal bile pigment – Bilirubin is the main pigment in bile and a major end product of hemoglobin breakdown
- Endogenous antioxidant – Bilirubin is a prominent endogenous antioxidant cytoprotectant with potent antioxidant activity, protecting cell membrane lipids from oxidative damage
- Anti-inflammatory and neuroprotective – Exhibits anti-inflammatory, immunomodulatory, cytoprotective, and neuroprotective properties
- Cardiovascular protection – Moderate serum bilirubin levels are associated with reduced risks of cardiovascular and metabolic diseases
- Traditional medicine active ingredient – Primary active compound in Calculus bovis (artificial bezoar / Niuhuang), a key traditional Chinese medicine ingredient
- Diagnostic applications – Critical component in IVD reagents for jaundice detection, liver function tests, and serum bilirubin determination
- Well-characterized molecule – Over a century of research, extensive toxicological and pharmacological data available
What is Bilirubin used for?
1. Diagnostic Applications (IVD):
- In vitro diagnostic reagents for quantitative determination of total bilirubin in human serum and plasma
- Calibration standards for jaundice detection and liver function tests
- Reference standards for clinical chemistry analyzers
2. Pharmaceutical and Research Applications:
- API and pharmaceutical intermediate
- Research chemical for biochemical and pharmacological studies
- Antioxidant and cytoprotective agent research
- Nanoparticle drug delivery systems research
- Traditional medicine formulations (Calculus bovis / artificial bezoar)
3. Industrial Applications:
- Raw material for artificial bezoar / Niuhuang production
- Biochemical research and analytical chemistry
- Synthesis of bilirubin derivatives
Note: All applications must comply with local regulatory requirements.
Frequently Asked Questions (FAQ)
Q: What is the purity level of your Bilirubin Powder?
A: Our Bilirubin Powder typically achieves ≥98.0% purity by HPLC. Higher purity grades (99%) are available upon request.
Q: What are the main impurities in bilirubin?
A: Key impurities include other bile pigments and degradation products. Total impurities are controlled to ≤2.0%, with water content ≤1.0%.
Q: Bilirubin powder safety and dosage guidelines
A: Bilirubin powder is for manufacturing, research, and diagnostic use only – not for direct human consumption. Safety guidelines: handle in well-ventilated areas; use appropriate personal protective equipment (gloves, goggles, lab coat); avoid dust formation; wash hands thoroughly after handling; store away from strong oxidizing agents. There are no established human dosages for bilirubin as a therapeutic agent because it is not administered directly to patients. For laboratory use, bilirubin standards are typically prepared at concentrations of 0–20 mg/dL for calibration curves.
Q: How to store bilirubin powder properly
A: Bilirubin is light-sensitive and should be stored in a cool, dry place, protected from light, in tightly sealed amber or light-protected containers. Short-term storage at 2–8°C is acceptable, but long-term storage at –20°C is recommended to maintain stability and prevent degradation. Under proper storage conditions, shelf life is 24–36 months. Repeated freeze-thaw cycles should be avoided. Protect from moisture and strong oxidizing agents.
Q: Common supplements that interact with bilirubin powder
A: Bilirubin powder is not intended for direct human consumption, so there are no established supplement interactions. However, bilirubin metabolism in the body can be influenced by certain natural compounds. Milk thistle (silymarin) and turmeric (curcumin) may affect bilirubin levels through their effects on liver enzymes. Green tea extract and resveratrol may also modulate bilirubin metabolism. For research purposes, these interactions should be considered when designing studies. Clinical use of bilirubin-based products should be evaluated by qualified healthcare professionals.
Our Advantages
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We are more than a supplier - we are a comprehensive supply chain partner dedicated to high-quality ingredients, custom formulations, and finished products across multiple industries.
With years of experience in plant extracts, food additives, cosmetic raw materials, and nutritional ingredients, our team brings deep technical knowledge and market insight to every partnership.
01. Diverse Product Range
We offer a broad range of products, including food additives, plant extracts, fruit & vegetable powders, cosmetic actives, and functional food ingredients.
- Raw Materials: High-purity ingredients for food, beverage, supplement, and cosmetic applications.
- Finished Products: In-house manufacturing of capsules, softgels, gummies, liquid drops, and blended powders.
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- Formulation & R&D: Expert support to develop custom blends, proprietary formulas, and innovative products.
- Global Logistics: Reliable shipping, documentation, and customs clearance support.
04. Quality Assurance
Strict adherence to cGMP standards and full regulatory transparency. We stay current with global requirements, including FDA GRAS, EFSA, and other regional regulations, to ensure your products meet the highest safety and compliance standards.
How to contact
Contact our sales team to discuss your requirements for Bilirubin Powder.
Please get in touch with us at ella.zhang@huilinbio-tech.com.
References
Disclaimer
This product is for manufacturing, research, and diagnostic use only. Not for direct human consumption. B2B info – not medical advice. Buyers must comply with regulations and obtain approvals. Specifications may change; verify current docs before ordering.
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