Hexapeptide-9 Powder | KTTKS Peptide | Matrixyl 5000 | Skin Barrier & Anti-Aging Cosmetic Ingredient
Source high-purity Hexapeptide-9 (KTTKS) for advanced cosmetic formulations. This collagen-stimulating peptide enhances skin barrier, reduces wrinkles & improves elasticity. Ideal for Serums & Creams.
Introduction: The Foundation of Youthful Skin
Hexapeptide-9 Powder, also known commercially as Matrixyl 5000, is a renowned bioactive fragment of the Prolactin protein. This synthetic pentapeptide (Lys-Thr-Thr-Lys-Ser, KTTKS) is a cornerstone ingredient for high-performance skincare, specifically engineered to signal the skin to repair itself. As a trusted B2B supplier of cosmetic actives, we provide formulators with a proven, high-purity ingredient to create products that deliver visible anti-aging and barrier-strengthening results.
Physicochemical Properties Table of KTTKS Peptide powder
| Property | Specification |
|---|---|
| Product Name | Hexapeptide-9 (KTTKS) |
| CAS Number | 885024-94-2 |
| Molecular Formula | C24H38N₈O9 |
| Molecular Weight | 582.61 g/mol |
| Purity | ≥ 98% (by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water (<1%), Glycerin |
| Storage | Store at -20°C ± 5°C in a sealed container, protected from light and moisture. |
| Shelf Life | 24 months under proper storage conditions. |
Mechanism of Action: Signal Skin to Rebuild
Hexapeptide-9 is a signal peptide that works by mimicking the body's own natural repair processes. Its sequence (KTTKS) is a fragment of the Prolactin protein, which is known to play a role in skin remodeling.
- Fibroblast Activation: Upon topical application and penetration, Hexapeptide-9 acts as a messenger to stimulate fibroblasts-the key cells in the dermis responsible for producing the Extracellular Matrix (ECM).
- Boosted ECM Production: This activation leads to an upregulated synthesis of essential structural proteins, most notably Type I and Type III Collagen, as well as Fibronectin [1].
- Structural Reinforcement: The increased production of these supportive proteins helps to rebuild the skin's foundational structure, leading to tangible improvements in firmness and texture.
Key Benefits of Hexapeptide-9 Powder
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Stimulates Collagen Production
Directly addresses the root cause of skin aging by boosting the skin's own production of key structural collagens, leading to a firmer, more resilient complexion.
-
Visibly Reduces Wrinkle Depth & Density
Clinical studies have shown that formulations containing Hexapeptide-9 significantly improve the appearance of fine lines and wrinkles by restoring the underlying skin structure [1].
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Improves Skin Elasticity & Firmness
By reinforcing the ECM, skin becomes bouncier and more toned.
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Strengthens the Skin Barrier
Enhanced production of ECM components supports a healthier, more robust skin barrier, improving hydration and resilience against environmental stressors.
Application of KTTKS Powder
Integrate Hexapeptide-9 Powder into a wide range of skincare solutions.
Recommended Concentration: 2% - 5% in the final product.
Ideal For:
Anti-Aging & Firming Serums
Intensive Repair Creams and Masks
Neck & Décolletage Treatments
Daily Moisturizers with Barrier Support
Formulation Tip: This peptide is stable and compatible with most cosmetic formulations. For best results, incorporate into the water phase at temperatures below 40°C.
Frequently Asked Questions (FAQ) about Hexapeptide-9
Q: What is the difference between Hexapeptide-9 (Matrixyl 5000) and Palmitoyl Pentapeptide-4 (Matrixyl 3000)?
A: Both are derived from the KTTKS sequence. Palmitoyl Pentapeptide-4 is a lipopeptide, where a palmitic acid chain is attached to enhance skin penetration. Hexapeptide-9 is the pure, non-acylated peptide. While both are effective, Hexapeptide-9 is valued for its high purity and is a fundamental building block for creating advanced peptide complexes.
Q: What is the recommended dosage of Hexapeptide-9?
A: For optimal efficacy in stimulating collagen and improving skin appearance, a concentration of 2% to 5% in the final formulation is recommended.
Q: Is Hexapeptide-9 safe for topical use?
A: Yes. Our Hexapeptide-9 is a synthetic peptide, ensuring high purity and batch-to-batch consistency. It is specifically designed for topical cosmetic use. We provide a comprehensive Certificate of Analysis (COA) with every batch to support your quality and safety protocols.
Q: Can we get a sample and what is the MOQ?
A: Yes, we offer samples for qualified companies. Please contact our sales team to discuss your project needs, request a sample, and learn about our flexible Minimum Order Quantity (MOQ).
Contact Us
Empower your formulations with the proven, regenerative power of Hexapeptide-9. Partner with us for a reliable supply of this benchmark anti-aging active.
Contact Us Today to request a technical data sheet, current pricing, and a sample. E-mail: ella.zhang@huilinbio-tech.com.
References
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