Product Overview: Premium NAD+ Precursor
Nicotinamide Riboside (NR) Powder, identified by CAS 1341-23-7, is a premium, fermentation-derived form of Vitamin B3. Recognized as a potent and efficient precursor to Nicotinamide Adenine Dinucleotide (NAD+), this Bulk NR Supplier grade ingredient is essential for formulators developing next-generation nutraceuticals. With a high 99% purity, our NR Powder is engineered to support cellular energy production, activate sirtuins, and promote healthy aging, making it an ideal raw material for cognitive, metabolic, and longevity-focused dietary supplements.
Product Specification
| Parameter | Specification |
|---|---|
| Product Name | Nicotinamide Riboside Chloride (NR Cl) |
| CAS Number | 1341-23-7 |
| Molecular Formula | C11H15NO5•Cl |
| Purity (by HPLC) | ≥ 99.0% |
| Appearance | White to off-white crystalline powder |
| Odor | Characteristic |
| Solubility | Freely soluble in water |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals (as Pb) | ≤ 10 ppm |
| Total Plate Count | ≤ 1000 cfu/g |
| Yeast & Mold | ≤ 100 cfu/g |
| Storage | Keep in a cool, dry, and dark place. Keep container tightly closed. |
| Shelf Life | 24 months under proper storage conditions. |
| Grade | Nutraceutical |
Mechanism of Action: A Precise NAD+ Booster
Nicotinamide Riboside's primary mechanism is its role as a highly efficient precursor in the biosynthesis of Nicotinamide Adenine Dinucleotide (NAD+). NAD+ is a critical coenzyme found in every cell and is essential for:
Cellular Energy Metabolism:
Acting as a key electron carrier in the mitochondria, driving the conversion of nutrients into adenosine triphosphate (ATP), the cell's primary energy currency.
Sirtuin Activation:
NAD+ is a crucial substrate for sirtuins, a class of proteins (Sirtuin 1-7) linked to cellular health, gene expression, and metabolic regulation. As a potent Sirtuin activator, NR supports the function of these "longevity proteins".
DNA Repair:
NAD+ fuels the activity of PARPs (Poly-ADP-ribose polymerases), enzymes essential for DNA repair and genomic stability.
Unlike other NAD+ precursors, NR utilizes a specific, two-step salvage pathway (via the NRK1 and NRK2 kinases) to convert directly into NAD+, making it a highly efficient and bioavailable NAD+ booster [1]. This distinct pathway establishes NR as a unique nutrient and a Preiss-Handler independent route to NAD+ [3].
Health Benefits
Formulators can leverage NR to create products that support the following areas of health and wellness:
Cellular Energy & Metabolism:
Supports healthy mitochondrial function and promotes efficient cellular energy production.*
Neurological & Cognitive Health:
Helps maintain neuronal health and supports cognitive functions such as memory and focus by promoting NAD+ levels in the brain.*
Healthy Aging:
Contributes to cellular maintenance and resilience. Supporting NAD+ levels helps activate sirtuins, which are associated with promoting healthy aging.*
Cardiometabolic Support:
Aids in the support of a healthy cardiovascular system and metabolic profile.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Applications in Nutraceutical Formulations
Our 99% pure, nutraceutical-grade NR Powder is ideal for a wide range of dietary supplement applications, offering excellent stability and solubility for:
- Capsules and Tablets: A standard and convenient delivery form for NR supplements.
- Powdered Drink Mixes: Ideal for nootropic stacks, energy supplements, and anti-aging formulations due to their high solubility.
- Sublingual Formulations: For potentially faster absorption.
- Functional Food and Beverage Fortification: Its neutral flavor and stability make it suitable for advanced health beverages.
Competitive Differentiation: NR vs. NMN vs. Niacinamide
| Feature | Nicotinamide Riboside (NR) | Nicotinamide Mononucleotide (NMN) | Niacinamide (NAM) |
|---|---|---|---|
| Precursor Role | Direct precursor to NMN and then NAD+. | Direct precursor to NAD+. | Direct precursor to NAD+. |
| Bioavailability | Well-absorbed via specific nucleoside transporters. Efficiently raises NAD+ [1, 2]. | Debate exists; some suggest it may need conversion to NR for cellular uptake. | Highly bioavailable but can cause a flushing effect at high doses. |
| Key Advantage | Efficient, well-researched pathway with strong clinical data for NAD+ boosting. | Popular and effective, with a large body of research. | Cost-effective. |
| Potential Limitation | Higher cost than Niacinamide. | Often more expensive than NR; ongoing debate on cellular uptake. | Can inhibit sirtuins (Sirt1) at high doses, potentially counteracting benefits. |
Conclusion for vs NMN: While both are excellent NAD+ precursors, NR's established and efficient pathway via NRK kinases and its strong clinical profile make it a top-tier choice for formulators seeking a proven, high-performance ingredient.
Frequently Asked Questions (FAQ)
Q: What is the typical dosage used in human studies?
A: Clinical trials have commonly used dosages ranging from 250 mg to 1000 mg per day, showing a significant increase in NAD+ levels and good tolerability [2].
Q: How does NR compare to NMN?
A: In short, NR is a direct precursor to NAD+ and does not require the conversion step that NMN does, which some research suggests may make it more efficient. The debate on bioavailability is ongoing, but both are effective.
Q: Is your NR suitable for vegan products?
A: Yes, our NR is derived via a fermentation process, making it suitable for vegan and vegetarian formulations.
Q: What is the shelf life and recommended storage?
A: The product has a shelf life of 24 months when stored in a cool, dry place, protected from light and moisture.
Product packaging introduction
|
Quantity |
Packaging |
|
1-3kg |
1-3kg/aluminum foil bag with food-grade plastic bag inside. |
|
4-25kg |
4-25kg/carton with double food-grade plastic bag inside. |
|
≥25kg |
25kg/drum or carton with double food-grade plastic bag inside. |
|
Delivery time |
Usually within 3-5 working days after receiving the payment. |
Shipping & Delivery
|
Express(DHL/TNT/FEDEX) |
By Air |
By Sea |
|
1-50kg |
50-500kgs |
Above 500kgs |
|
Fast and convenient |
Fast and cheap |
Cheap and long time |
|
4-8 days |
4-8 days |
15-45 days |
|
Door to door |
To airport |
To port |
How to contact us?
Our company is a professional supplier of semi-finished materials, including plant extracts, fruit and vegetable powder, cosmetics, tablet candy, and other products. Our products are directly supplied from the manufacturer, so the price is very favorable, and the quality is guaranteed, so that you can buy with confidence.
Now our company is hot-selling high-quality Nicotinamide Riboside (NR) Powder. If you are interested in this product and want to know about it, you can consult our account manager through the international website or email. Our email address is ella.zhang@huilinbio-tech.com.
References
- Canto, C., et al. (2012). The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity. Cell Metabolism, 15(6), 838-847.
- Trammell, S. A., et al. (2016). Nicotinamide Riboside Is Unique and Orally Bioavailable in Mice and Humans. Nature Communications, 7, 12948.
- Bieganowski, P., & Brenner, C. (2004). Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans. Cell, 117(4), 495-502.
Compliance Disclaimer
*This information is intended for business-to-business (B2B) customers only. Nicotinamide Riboside Powder is a dietary ingredient for use in dietary supplement formulations. It is not a drug and is not intended for direct consumer sale in its raw form. The product and any claims associated with its use are the sole responsibility of the finished product brand. It is the responsibility of the finished product manufacturer to ensure compliance with all applicable local, state, federal, and international laws and regulations, including FDA and FTC guidelines (DSHEA in the U.S.) and EFSA regulations (in the E.U.). We recommend consulting with your legal and regulatory team before making any product claims.*
Contact Xi'an Huilin Bio Tech today to discuss your project needs, request a sample, or get a competitive quote for bulk quantities.
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