Description of vincamine
Vincamine Powder (vincamine) is one of the main alkaloids in Vincamine. It is a white powder which is soluble in acidic solution. It is a white rock-solid alkaloid in monoterpene indole alkaloids. In 1953, Schlittle and Furlenmeier isolated the Chemicalbook from V. mainor. In 1962, Trojanek, Mokry, Clauder et al determined its chemical structure. In 1968, Trojanek, Blaha et al. determined the spatial configuration of vincamines. The structure of natural Changchun amine is dextral, and the synthetic Changchun amine is racemic. To a certain extent, Changchun amine has the functions of regulating brain circulation, maintaining nerve homeostasis, protecting nerve and anti-oxidation.
|
Melting point |
232°C(dec.)(lit.) |
|
Specific rotation |
42.8º(c=1inpyridine) |
|
Boiling point |
487.66°C(roughestimate) |
|
Density |
1.1640(roughestimate) |
|
Refractive index |
1.6500(estimate) |
|
Storage conditions |
Keep in dark place, Inert atmosphere, 2-8 ° C |
|
Solubility Chloroform |
(SlightlyChemicalbook),DMSO(Slightly) |
|
Form |
Solid |
|
Predicted Acidity coefficient(pKa) |
12.13±0.40 |
|
Color |
White to Off-White |
|
opticalactivity |
[α]23/D+42.8°,c=1inpyridineMerck14,9983 |
|
Stability |
Hygroscopic NIST |
|
Chemical information |
Vincamine |
|
Cas no |
1617-90-9 |
Vincamine mechanism of action
1. Treatment of ischemic cardiovascular and cerebrovascular diseases: vincristine has no effect on brain blood flow, but significantly reduces ischemic areas and improves patients' memory test scores. Vinamine can obviously improve the symptoms of patients with chronic ischemic heart and encephalopathy, the curative effect is satisfactory, but the long-term effect needs to be further observed. Recent studies have shown that vincristine has regulating effects on arterial blood pressure, cardiac output and heart rate. Vinamine is a cerebrovascular dilator with high lipid solubility and easy absorption. Through the blood-brain barrier, it can maintain or restore the physiological dilation of blood vessels, restore normal blood flow in the ischemic area, improve the utilization rate of blood oxygen, improve the metabolism of ischemic tissue, protect neurons, etc.
2. Improve your memory: Vinamine (1 mg/kg) and piracetam (300 mg/kg) both increased the relative and absolute values of sleep with little effect on slow wave and overall sleep, but the stimulant effect of sleep with sleep with sleep enhanced memory. Vinamine has a good effect on Alzheimer's disease, which can improve patients' motor ability, memory and cognitive function. Changchun amine can significantly increase the relative or absolute amount of heterogeneous sleep, but has little effect on slow wave sleep and total sleep.
|
|
|
3. Vincamine Powder can treat dementia:Treatment of primary degenerative and vascular dementia with vinvinamine. During 12 weeks of double-blind treatment, patients treated with vinamine at 30 mg daily or an equivalent dose of placebo showed significantly better performance scores on the Texas-based Clinical Assessment Scale for Geriatrics (SCAG) and Short-term Cognitive Ability Test (SK T) than the control group.
4. Improve vision: Vinamine has a good effect on the recovery of neuronal function after retinal contusion. Vinamine injection has obvious curative effect on eye ischemic lesions, and the improvement degree of vision, field of vision and fundus is obviously better than that of Torazolin injection alone, with fewer adverse reactions and obvious curative effect on primary ischemic optic nerve retinochoroidal lesions. Vinamine can improve and promote fundus blood circulation, increase adenosine activity by inhibiting adenosine uptake, promote nerve cell function recovery and nerve fiber regeneration, and improve visual acuity.
5. Other medicinal value:
The physiological effects of vinamine on the hippocampal CA1 region of the brain were studied. After continuous infusion of 100 mmol/L-1 vinamine for 5 min, the post-tonic and long-term enhancement induced by repeated stimulation of the nervous system of Schaffer-commissural could be significantly reduced or even completely suppressed.
Preparation method of vincamine
A preparation method for Changchun amine comprises the following steps:
1) Preparation of bonin: in petroleum ether, concentrated ammonia water is used to dissociate bonin hydrochloride, and then acid salt solution is added to remove the remaining ammonia water. After the reaction is completed, the liquid is divided, the water layer is extracted with petroleum ether, the organic phase is combined, the organic phase is dried with desiccant and filtered, and the filtrate is distilled under pressure to obtain bonin;
2) Preparation of Longspring Manfermin: the tabonine obtained in step (1) was dissolved in organic solvent, and the reaction was carried out at a certain temperature by adding Pd/C, hydrogen atmosphere and atmospheric pressure under stirring. TLC was used to monitor the end point of the reaction, filtrate was filtered, and the filtrate was distilled under vacuum pressure to obtain Longspring Manfermin
3) Preparation of mono peroxy maleic acid: N, n-dimethylformamide was dissolved by adding Chemicalbook anhydride of maleic acid, and 30% hydrogen peroxide was added to the mixture. After the drip, the reaction was carried out. After the reaction was finished, the temperature was lowered and diluted with cold methanol for reserve.
1) Preparation of Changchun amine: After cooling down, a certain amount of mono peroxymaleic acid obtained in step (2) was added to the solution. After a period of oxidation reaction, a certain amount of mono peroxymaleic acid was added to the solution, and the oxidation reaction was continued for a period of time. After the reaction was completed, the reducing agent solution was added to the starch KI test paper without changing color, and the rearrangement reaction was carried out at high temperature. After the reaction is completed, the temperature drops to 20-30℃, and a certain amount of water and concentrated ammonia are added to adjust the pH to a certain range. Then, the temperature drops to crystallization and filtration. After the filter cake is washed with methanol and water, the pulp is pulped with water at a certain temperature.
Benefits of vinblastine powder
Excellent weather resistance: Vinyl amine powder can provide excellent weather resistance, so that the coating can keep bright colors and smooth surface for a long time, and it is not easy to be eroded by ultraviolet rays and oxidation.
Good corrosion resistance: Vinyl amine powder can form a solid protective film, which can effectively prevent metal materials from corrosion and oxidation and prolong their service life.
High wear resistance: adding vinblastine powder to the coating can increase the hardness and wear resistance of the coating and protect the coated object from scratch and wear.
Reduce the emission of volatile organic compounds (VOC): Vinyl amine powder can be used as a material to replace solvents, which reduces the content of volatile organic compounds in coatings and is more environmentally friendly.
Characteristics of vinblastine powder
Good weatherability: Vinyl amine powder can resist ultraviolet rays, oxidation, corrosion and chemical erosion, and keep the color and luster of the coating for a long time.
High abrasion resistance: the coating added with vinblastine powder has excellent hardness and abrasion resistance, which can effectively protect the surface of the coated object from scratches and abrasion.
Corrosion resistance: Vinyl amine powder can form a solid protective film, which can effectively prevent metal materials from corrosion and oxidation.
Excellent chemical stability: Vinyl amine powder has strong resistance to chemicals, so that the coating can still maintain good performance in the environment of chemical corrosion.
Emission of low volatile organic compounds (VOC): Using vinblastine powder as pigment can reduce the VOC content in the paint, which is environmentally friendly.
How to contact us?
Our company is a professional supplier of semi-finished raw materials, including plant extract, fruit and vegetable powder, cosmetics, tablet candy and other kinds of products; Our products are supplied directly from the manufacturer, so the price is very favorable, and the quality is guaranteed, so you can rest assured to buy. Today, we are selling Vincamine Powder, a premium additive to health care, medicine, skin care and other products.
If you are interested in this product and want to know more about it, you can consult our account manager through the international website or email, our email address is ella.zhang@huilinbio-tech.com; Our factory is located in Room 706, Building B, Fengze Science Park, No.170 West Street, Yanta District, Xi 'an City, Shaanxi Province.