Introduction of Vincamine
Vincamine Powder is an alkaloid extracted from the Phlox plant Vincami-norL, which is now semi-synthetic as a cerebrovascular dilator. This preparation contains tartrate and Teprosilate in addition to hydrochloride. vincamine (VIN) belongs to the white hardwood alkaloids in monoterpenoid indole alkaloids, which can be isolated from Vincamine and Chemicalbook orange. Vinamine has the functions of lowering blood glucose, protecting liver, anti-tumor and preventing cardiovascular and cerebrovascular diseases. Although VIN is currently used as tablets and slow-release capsules, its complex chemical structure and oil-philic properties lead to its low water solubility and poor oral bioavailability, which greatly limits its clinical application. Cyclodextrin is widely used as a drug carrier, which can improve the water solubility and stability of drugs.Vinamine is a drug, used for stroke, ischemic hypertensive encephalopathy, cerebral arterial sclerosis, cerebral ischemia, cerebral embolism, suitable for the elimination of symptoms of progeric degeneration of the brain, such as vertigo, headache, memory loss, inattention, aphasia, Meniere's syndrome, etc. It can also be used for retinal hemorrhage, nerve tachycardia and other vegetative nerve disorders.
Product name | vincristine |
English name | Vincamine, ethyl abrovinaminate, vincristine, long - acting vinamine, Shinaomai-30 Aethroma-30, Angiopac, Arteriovinca, Devincan, Minorin, Perrone, Perval, Pervincamine, Vinca, Vincagil, Vincalex |
Sourc | This strain is an alkaloid extracted from the Phlox plant Vincami-norL, which is now semi-synthetic as a cerebrovascular dilator. This preparation contains tartrate and Teprosilate in addition to hydrochloride. |
Color | White powder |
Source | Flower |
Shelf time | 2 years |
what is vincamine used for?
1.Vinvinamine can pass through the blood-brain barrier to maintain and restore the oxidative catabolism of glucose in the brain tissue of the diseased area, and normalize the production of lactic acid and the release of carbon dioxide, thus expanding cerebral small blood vessels and improving cerebral circulation; The blood flow in the normal brain tissue and the normal brain area of the patient's brain tissue was not significantly affected, and the systemic blood circulation was not affected. There is also a mild sedative effect.
2. The mechanism of vinvinamine in the treatment of ischemic cerebrovascular diseases includes: improving the utilization rate of oxygen and glucose in brain tissue; Dilate cerebrovascular and improve microcirculation;
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3. Block calcium ion slow channel and voltage-gated sodium ion channel;
4. Anti-oxidation;
5.Protect nerve function
Indications are applicable to cerebrovascular sclerosis, brain insufficiency and vascular diseases of the eye, ear, nose and throat. It is especially suitable for the early manifestations of progressive brain dysfunction, such as vertigo, headache, memory loss, fatigue, inattention and so on. It can also be used for brain degeneration in the elderly and its symptoms such as anxiety, aggression, stress, motor difficulties, slow thinking, irritability in the elderly and sphincter disorders, as well as the acute manifestations and sequelae of craniocerebral injury, such as coma after injury, disturbance of consciousness, hemiplegia (hemiplegia), speech disorders, conscious symptoms of brain injury and arterial dementia. In addition, it also has a certain effect on retinal vascular sclerosis, cochlear disorders caused by blood vessels, such as dizziness and Meniere syndrome.
Safety Information
Dangerous Goods Mark | Xn |
Danger category code | 22 |
Safety Description | 36-26 |
WGKGermany | 3 |
RTECS number | YY8575000 |
Customs Code | 29399990 |
Poison material data | 1617-90-9 (Hazardou Substances Data) |
Toxic | LD50inmice(mg/kg):75i.v.; > 1000 s. c. (Szporny, Szasz); 1000orally(Szabo,Nagy) |
Vincamine side effects
1. It cannot be used in patients with intracranial tumors, increased intracranial pressure, pregnant women, or patients with brain-derived spasm.
2. For patients with myocardial infarction sequelae and organic disorders of arrhythmia, the dosage of this product should be gradually increased and electrogram monitoring should be used if necessary.
3. Generally well tolerated, nausea, vomiting, abdominal pain, constipation and other gastrointestinal discomfort, occasionally unease, insomnia, urticaria. Injections can cause excessive sweating.
Tablets :10mg/ tablet. Injection :10mg/2ml.
Aethromia-30 was administered with 60mg of common vinvinamine preparation once. The serum concentration was 12.5μg/ml for 8 hours, and T1/2 was 1 hour 40 minutes. The drug concentration was 17.5μg/ml, T1/2 was about 7 hours, and the bioavailability was about 3 times that of the common preparation. This product is taken orally 30mg each time, twice a day. Severe cases can be increased to 90mg/ day. After 3-6 weeks, the maintenance dose is 30mg/ day.
How to contact us?
We are a company with many years of sales experience in the plant extract industry. After years of operation, we have a wide range of products, such as fruit and vegetable powder, cosmetics, tablet candy and other products. We are a professional raw material supplier. At present, our company is selling cheap bulk Vincamine Powder, which is widely used in health care products, medicine, cosmetics and other fields. Those who need to make health care products can buy this raw material. Meanwhile, as our products are sold directly from the manufacturer, the quality is guaranteed and you can rest assured to buy them.
If you need to buy or are interested in it, you can send an email to our work email address ella.zhang@huilinbio-tech.com through the international website. We will reply you as soon as you see the message. In addition, you can also visit the offline field. Our company is located in Room 706, Building B, Fengze Science Park, No. 170, West Street, Yanta District, Xi 'an City, Shaanxi Province. Welcome to your visit.