10-Hydroxy-2-decenoic Acid

Royal jelly acid, chemically known as 10-Hydroxy-2-decenoic acid (10-HDA), is a unique ingredient in royal jelly, and is the most important indicator of the quality of royal jelly, with which many of its properties, such as odor and pH value, are related. Royal jelly is a kind of milky white or light yellow, slightly sweet and slightly sour and astringent viscous liquid secreted by the nutrient glands in the head of worker bees, which has the physiological effects of enhancing body resistance, antibacterial and anti-inflammatory as well as high nutritional value. Therefore, royal jelly has been widely emphasized. Scientists have isolated an organic acid, 10-hydroxy-Δ2-decenoic acid (HDA), from royal jelly.

1.Antibacterial and anti-inflammatory

Royal jelly acid has strong inhibitory effect on many kinds of bacteria such as Escherichia coli, Staphylococcus aureus, Streptococcus galactophilus, Staphylococcus intermedius B, Staphylococcus xylosus, Salmonella cholera, Vibrio parahaemolyticus, and Escherichia coli (haemolytic), and even stronger than the anti-bacterial effect of penicillin and chloramphenicol.

2.Enhancement of immunity

10-HDA can inhibit the proliferation of activated T-cells, increase the phagocytic activity of macrophages, and inhibit the production of inflammatory factors and nitric oxide, so as to maintain the balance of the immune system, improve the body's immune function, and prevent the occurrence of infections and diseases. It has a certain effect on the prevention and treatment of immunocompromise caused by old age, disease or physical failure.

3. Anti-radiation

HDA can protect the skin from UV radiation, it has a significant protective effect on acute radiation damage. It can inhibit UV-induced cytotoxicity and the production of reactive oxygen species, and can protect and restore the body's core substances such as proteins, ribonucleic acid and deoxyribonucleic acid, thereby protecting the skin from damage.

4. Antioxidant activity

It can protect the skin from UV-induced photoaging by promoting the production of collagen, prevent and control skin aging, and play a cosmetic effect.

5. Lowering blood lipids

Experiments have shown that Queen bee acid can improve fat metabolism in the liver and other organs, reduce triglyceride content in the blood, and help treat hyperlipidemia and obesity.

1.Pharmaceutical field

HDA has significant antibacterial and anti-inflammatory effects, which can kill hepatitis virus and inhibit its growth in liver cells, promote the regeneration of liver cells, and prevent the occurrence of cirrhosis and hepatitis and other diseases. It also inhibits the reproduction of pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Mycobacterium avium, Mycobacterium tuberculosis, etc., and has a wide range of antibacterial effects. In addition, it has anti-radiation effect, which can protect the immune state of the body and assist in the treatment of acute radiation damage.

2. Cosmetic field

HDA can delay aging and maintain skin health, and its multi-functional target mechanism research and application of biosynthesis technology make it has great potential in the field of cosmetics, and has been filed successfully as a new raw material.

3.Food field

It can balance the metabolism of fat and sugar in human body, and has the effect of lowering blood pressure and blood fat, especially suitable for the consumption of people with three highs, and can be used as a food additive to make food suitable for the consumption of people with three highs.

Grignard reagent method: hexanediol as raw material, 5- [(tetrahydro-2-furyl)oxy]pentyl chloride as Grignard reagent, so that β-vinyl-β-lactone ring-opening, acid treatment, add alkali to make the double bond shift, can also be obtained from the royal jelly acid, the synthetic route is:

We have an experienced research team dedicated to the research and development of 10-Hydroxy-2-decenoic acid(HDA). They cooperate with many scientific research institutions and universities to innovate and improve constantly to keep their products competitive in the market. We pay attention to the latest scientific research progress and technical trends to ensure the quality and effect of products.

If you need this product, please get in touch with us at ella.zhang@huilinbio-tech.com.

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