Introduction
Phosphatidylserine (PS) is a naturally occurring phospholipid and an essential component of human cell membranes, particularly concentrated in brain tissue where it accounts for approximately 10–15% of total brain phospholipids. It plays a critical role in maintaining cell membrane fluidity and integrity, while also participating in the regulation of neural signaling pathways, cerebral energy metabolism, and defense against neuro-oxidative stress and inflammation.
Commercially, PS is produced through enzymatic conversion from soybean or sunflower lecithin. Historically sourced from bovine cortex, modern PS production has transitioned to plant-based sources due to BSE concerns, making it suitable for vegetarian and vegan formulations. PS from sunflower oil is chemically indistinguishable from soy-derived PS and offers a soy-free alternative.
PS is recognized as a non-essential nutrient that can be synthesized by the body, but supplementation has been extensively studied for its cognitive and physiological benefits. In China, PS was included in the New Resource Food directory in 2010. The U.S. FDA has issued no-objection letters to multiple GRAS notices for PS derived from soy lecithin.
Our Phosphatidylserine Powder is manufactured through enzymatic conversion from non-GMO soybean or sunflower lecithin, followed by purification and spray-drying. Available in 20%, 50%, and 70% PS content specifications, all verified by HPLC-ELSD, our product ensures consistent quality, purity, and batch-to-batch reproducibility.
Technical Information
| Parameter | Specification / Information |
|---|---|
| Product Name | Phosphatidylserine Powder |
| CAS No. | 51446-62-9 (monomer); 84776-79-4 (industrial mixture) |
| HS Code | 2923200000 |
| Source | Soybean lecithin / Sunflower lecithin (enzyme conversion) |
| Appearance | Off-white to light yellow fine powder |
| Odor | Characteristic, slight |
| Particle Size | 80 mesh (D90 < 250 μm) |
| Solubility | Insoluble in water; dispersible in water systems; soluble in chloroform; partially soluble in ethanol |
| Assay (PS Content) | 20%, 50%, 70% (HPLC-ELSD) |
| Loss on Drying | ≤ 3.0% |
| Ash Content | ≤ 8.0% |
| Peroxide Value | ≤ 5.0 meq/kg |
| Heavy Metals | Pb ≤ 2 ppm; As ≤ 1 ppm; Cd ≤ 1 ppm; Hg ≤ 0.1 ppm |
| Microbiological | TPC ≤ 1,000 cfu/g; Yeast & Mold ≤ 100 cfu/g; E. coli & Salmonella: negative |
| Shelf Life | 24 months |
| Storage | Cool, dry, light-protected; 15–25°C; reseal promptly |
| Regulatory Status | China New Resource Food (2010); FDA GRAS; EFSA novel food approved |
Benefits
Phosphatidylserine offers a wide range of health benefits, supported by extensive clinical research and over 50 clinical studies:
- Cognitive Function Support – PS has been shown to improve memory, processing speed, and attention span in older adults. A meta-analysis concluded that PS has a positive effect on the memory of older adults with cognitive decline. A 2025 randomized controlled trial found that daily PS supplementation at 300 mg/day significantly improved psychomotor speed in healthy adults with subjective cognitive decline.
- Stress Reduction – PS helps minimize feelings of stress and lowers cortisol levels by up to 30% under high-pressure conditions. It has been shown to reduce the severity of depression and improve mood.
- Athletic Performance – PS may help decrease muscle soreness and reduce the number of stress hormones released during and after physical activity. In a study of active young men, supplementation with phosphatidylserine increased the time they could exercise until exhaustion by approximately 25%.
- Neuroprotection – PS has demonstrated neuroprotective properties in Alzheimer's disease models, reducing cytotoxicity and preserving neuronal viability. It also helps normalize age-related decreases in Na+/K+ ATPase activity in brain cells.
- Skin Health – PS supports overall skin health and has been clinically tested for its benefits in this area.
- Versatile Formulation – Available in 20%, 50%, and 70% PS content specifications to suit different product needs, from mass-market supplements to premium nutraceuticals.
Specifications & Applications Guide
| Specification | Concentration / Content | Recommended Applications | Key Considerations |
|---|---|---|---|
| Ratio 4:1 – 10:1 | Low–medium concentration | Standard dietary supplements, capsules, tablets | Mild concentration; broader phytochemical retention; cost‑effective |
| Ratio 10:1 – 20:1 | Medium–high concentration | High‑potency supplements, functional beverages | Higher concentration; reduced dosage volume |
| Agnuside 0.5% | HPLC standardized | Standardized supplements, capsules, tablets | Industry baseline specification; USP reference |
| Agnuside 1% – 2% | HPLC standardized | Premium supplements, high‑potency formulations | Higher agnuside content for enhanced bioactivity |
| Vitexin 5% | UV/HPLC | Standardized supplements, functional foods | Key flavonoid marker; well‑studied bioactivity |
| Casticin 0.3% – 0.5% | HPLC | High‑purity formulations, pharmaceutical research | Major flavonoid; considered key active constituent |
| Total Flavonoids | UV (custom levels) | Antioxidant formulations, wellness products | Broad flavonoid profile for comprehensive activity |
| Custom | Customizable | Tailored formulations | Available upon request; flexible specifications |
Frequently Asked Questions (FAQ)
Q: What is the difference between soy-derived and sunflower-derived phosphatidylserine?
A: Both are chemically and functionally identical. Sunflower-derived PS offers a soy-free, non-GMO alternative suitable for consumers with soy allergies. Most clinical research has utilized soy-derived or bovine-sourced PS, but sunflower-derived PS is equally effective.
Q: What is the recommended daily intake of phosphatidylserine?
A: Typical dietary supplement dosages range from 100–300 mg/day. Clinical studies have used dosages of 100–300 mg/day for cognitive support, with 300 mg/day being common in many trials. For athletic performance, higher dosages such as 750 mg/day have been studied. We recommend consulting with a formulation specialist for application-specific guidance.
Q: Is phosphatidylserine safe for long-term use?
A: Yes. Multiple clinical trials have demonstrated that PS is safe and well-tolerated with no significant adverse events. A 2025 randomized trial confirmed that regular daily consumption of 300 mg/day PS is safe. Studies in children aged 8–12 years also showed that 100 mg/day PS supplementation was safe and well tolerated. Clinical evaluation and laboratory tests have consistently demonstrated that PS is well tolerated.
Q: Is phosphatidylserine suitable for vegetarians and vegans?
A: Yes. Our PS is derived from plant-based sources-soybean or sunflower lecithin-making it suitable for vegetarian and vegan formulations.
Q: Does phosphatidylserine dissolve in water?
A: No. PS is lipophilic and insoluble in water, though it can disperse in water systems. It is soluble in chloroform and partially soluble in ethanol.
Q: What is the significance of PS purity?
A: Higher PS purity has been shown to enhance neuroprotective effects. A 2026 study demonstrated that 80% PS purity significantly increases SIRT1 and PGC-1α levels, strengthening neuroprotective pathways and improving mitochondrial quality control.
Q: What are the main applications of phosphatidylserine?
A: PS is widely used in dietary supplements (capsules, tablets, soft gels, sachets, gummies), functional foods and beverages (milk, yogurt, powdered drinks, energy gels), sports nutrition products, and cosmetics.
Q: What certifications are available?
A: Our Phosphatidylserine Powder is manufactured in ISO, HACCP, KOSHER, and HALAL certified facilities with GMP-compliant production processes.
For inquiries, quotations, or sample requests, please contact: sales@huilinbio-tech.com
References
1. Jeon SM, Cho S, Lee YS, et al. Higher Purity of Phosphatidylserine Improves Human Cortical Neuron Function by Modulating SIRT1-PGC-1α Pathways. Brain Sciences. 2026;16(2):194. doi:10.3390/brainsci16020194. Key finding: Higher PS purity enhances SIRT1 and PGC-1α expression, strengthening neuroprotective pathways and improving mitochondrial quality control.
Link: https://doi.org/10.3390/brainsci16020194
2. Liu Y, Lu Y, Tang Y. Phosphatidylserine Supplementation on Psychomotor Speed among Healthy Adults with Subjective Cognitive Declines. Innovation in Aging. 2025;9(Supplement_2):igaf122.3233. doi:10.1093/geroni/igaf122.3233. Key finding: Daily PS supplementation at 300 mg/day significantly improved psychomotor speed in healthy adults with subjective cognitive decline; no adverse events observed.
Link: https://doi.org/10.1093/geroni/igaf122.3233
3. Effect of phosphatidylserine on cognitive function in the elderly: A systematic review and meta-analysis. Korean Citation Index. Key finding: PS has a positive effect on the memory of older adults with cognitive decline; PS dosage varied from 100–300 mg/day; no adverse effects.
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