Introduction of Vinblastine
Vinblastine Powder is high purity ingredient. Catharanthusroseus(Linn.)G. daon is a whole grass extract of Catharanthusroseus(Linn.) G.daon, Apocynaceae. Changchun, also known as Yanlahong, daily new, four spring, thirty thousand flowers, etc., mainly produced in Hainan, Yunnan, Guangdong, Guangxi and other places. Changchun Chemicalbook flower taste slightly bitter, cool, return to the liver meridian, with detoxification, Qingreping liver and other effects. Rich in terpenoid alkaloids, dipolyindole alkaloids, monoindole alkaloids and flavonoids, the extract of roseus catharsis has therapeutic effects on various tumors, hypertension, carbonic cancer, scalding, malaria, diarrhea and Hodgkin's disease, and has pharmacological activities such as hypoglycemia and diuretic
Subshrubs, slightly branched, up to 60cm, SAP at break, glabrous or only glabrous throughout; Stems subsquare, striate, gray-green; The internode length is 1 ~ 3.5cm. Leaves of Chemicalbook membranous, obovate oblong, 3 ~ 4cm long, 1.5 ~ 2.5cm wide, apex rounded, short pointed, base broadly cuneate to cuneate, narrow into petiole; Lateral veins are about 8 pairs
Mechanism of action of vinblastine
1.. Antihypertensive effect: Intravenous injection of Vinca total alkali has antihypertensive effect on anesthetised cats and rabbits, and the blood pressure drops rapidly, which is different from the slow antihypertensive effect of Roflum total alkali preparation, and the antihypertensive effect is accompanied by the deepening of respiration and the amplitude increases. Cutting the vagus nerve or using atropine did not affect its antihypertensive effect. Total alkali also has the effect of dilating coronary vessels (belong to spasmolytic ganglion blocker).
2. Hypoglycemic effect in the treatment of diabetes mellitus with Changchun Mosaic and whole plant. Vinblastine, epoxy-vinblastine, Roxyline and tetrahydrochicken bone Changshan were all isolated from Catharanthus roseus with different degrees of hypoglycemic effects, starting slowly but lasting. The water extract of leaves can also lower blood sugar in normal rabbits and dogs with diabetes caused by alloxacil.
3. Vinblastine Powder has Diuretic effect The extract Vindolinine has diuretic effect on rats under saline load.
4. Other effects Total Vinca alkali has no excitatory effect on the uterus and intestines in vitro, but large dose has inhibitory effect on the heart in vitro. It can be used as a hemostatic agent when uterine bleeding is introduced abroad, and its root can be used for abortion. All the alkaloid parts have different degree of antibacterial action.
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Primroses alkaloid derivatives are the products of structural modification of vinca alkaloid from two aspects. First, according to the structure-activity relationship of vinca alkaloid, the active center of vinca alkaloid was modified to synthesize a series of vinca alkaloid derivatives, in order to find the vinca alkaloid with stronger pharmacological activity, lower toxicity and wider anti-tumor spectrum. Second, under the premise of ensuring pharmacological activity, targeting groups (specific oligopeptides, monoclonal antibodies and folic acid, etc.) were introduced into some inactive sites to synthesize a series of targeted precursors of vinca alkaloid derivatives, in order to reduce the adverse reactions of vinca alkaloid drugs and improve its therapeutic index. Changchun Fluning is a difluorine-substituted alkaloid derivative of Changchun by activating the C-20 'site of vinblastine base in super-acid environment with Vinblastrebine as starting material. Studies have shown that the affinity of Vinflunin to tubulin binding sites is much smaller than that of other vinca alkaloids, and the helix induced by Vinflunin is smaller and the helix relaxation time is shorter, so it can be cleared out of cells in a shorter time, which makes the neurotoxicity of Vinflunin weakened. Moreover, the inhibitory rate of vinflunine on tumor growth in vivo was higher than vinvinorobin
Use of vinblastine
1.22 cases of Hodgkin's disease, 11 cases of lymphatic sarcoma, 1 case of malignant reticulum cell hyperplasia, mycosis fungoides, leukemia, green tumor, mediastinal tumor and 6 cases of reticulum cell sarcoma were treated with vincristine sulfate. Results Completely disappeared in 4 cases, effective in 15 cases, effective in 12 cases, ineffective in 6 cases, worsening in 3 cases, unknown in 3 cases, the total effective rate of 72.1%.
2. Vinblastine sulfate 10mg(once dose), twice a week, intravenously, total 50mg. 5 cases of acute lymphoid leukemia, 1 case of subacute lymphoid leukemia and 2 cases of acute and chronic myelogenous leukemia were treated. Results: 2 cases disappeared completely and 3 cases showed obvious effect.
3. Hypertension patients with Catharina Siegesbeckiae 12g, Herba Siegesbeckiae 9g, cassia and chrysanthemum 6g each. Decoction with water has a better effect on lowering blood pressure.How to contact us?
We are a company with many years of sales experience in the plant extract industry. After years of operation, we have a wide range of products, such as fruit and vegetable powder, cosmetics, tablet candy and other products. We are a professional raw material supplier. At present, our company is selling cheap Vinblastine Powder in bulk, which is widely used in health care products, medicine, cosmetics and other fields. Those who need to make health care products can buy this raw material. Meanwhile, as our products are sold directly from the manufacturer, the quality of our products is guaranteed and we can rest assured to buy them.
If you need to buy or are interested in it, you can send an email to our work email address ella.zhang@huilinbio-tech.com through the international website. We will reply you as soon as you see the message. In addition, you can also visit the offline field. Our company is located in Room 706, Building B, Fengze Science Park, No. 170, West Street, Yanta District, Xi 'an City, Shaanxi Province. Welcome to your visit.