What is the use of idebenone powder in medicine?

Basic Information on Idebenone

The chemical name of idebenone powder is 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylbenzoquinone, which is an orange-yellow or orange crystalline substance. The product is insoluble in water, soluble in methanol, ethanol, and other solvents, has no particular smell, and its properties are very stable.

Idebenone was developed and marketed in 1986, which can effectively improve brain dysfunction, improve the utilization of glucose in the brain, and promote the generation of ATP; at the same time, it also has strong antioxidant properties, which are good in scavenging free radicals effect. Clinically, this product is mainly used for the nervous system, such as Parkinson's disease, etc. From the efficacy of this substance, this product can be effectively used in the fields of health care products and medicine, and is an effective raw material in these fields.

The preparation method of idebenone

1. Put 3-4-5-trimethoxytoluene, 10-acetoxydecanoyl chloride, and aluminum trichloride in dichloroethane, cool with ice, and stir to react.

2. Put in ice water, extract dichloromethane, and then obtain 6-(10-acetoxy-1-oxodecyl)-2,3-dimethoxy-5-methyl phenol as a light brown oil.

3. Add methanol and sodium hydroxide to stir, then evaporate the solvent, add water, finally filter, separate out crystals, and vacuum dry to obtain the crude product.

4. Dissolve the crude product in chloroform, separate it with a silica gel column, then elute, collect the required components, evaporate the solvent, and then recrystallize to obtain a white crystalline 6-(10-hydroxy-1- oxodecyl)-2,3-dimethoxy-5-methyl phenol.

5. Mixed with acetic acid, Pd-C, and perchloric acid, and hydrogenated at room temperature and pressure to carry out the reaction. Then the catalyst was filtered off, concentrated, and then dichloromethane was added to carry out steps such as washing, drying, and distilling off the solvent to obtain 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl as light-colored oil phenol.

6. Mix the oil with freshly prepared Fremite salt, dimethylformamide water-methanol, and potassium dihydrogen phosphate, etc., stir, and after the reaction is complete, add water to dilute, and then extract with dichloromethane. , and then through the steps of washing, drying, recrystallization, etc., idebenone is finally obtained.

Uses of Idebenone

1. It can effectively prevent senile dementia, and improve brain function, metabolism, and mental symptoms.

2. It has a good effect on reducing blood pressure.

3. Can inhibit the generation of lipid peroxides in brain mitochondria.

4. Idebenone powder has a strong antioxidant effect.

5. It has a good effect on improving brain energy metabolism.

6. It can improve the utilization of glucose in the brain and increase the production of ATP.

7. It can improve brain dysfunction, low consciousness, emotional disorders, language barriers, dementia, and other diseases caused by cerebral hemorrhage.

Clinical application

1. It can be applied to a variety of neurological diseases, and has a good effect on Parkinson's, Alzheimer's disease, and other diseases.

2. It can be used for the treatment of a series of diseases, such as language disorders.

3. For the treatment of cardiovascular and cerebrovascular diseases.

Idebenone side effects

Note: The incidence of side effects for this product is 3.77%.

1. Allergies: Occasionally, rashes and other skin phenomena may occur.

2. In terms of the digestive system: Nausea, loss of appetite, diarrhea, and other problems may occur.

3. For the nervous system: there will be symptoms of excitement.

4. It may reduce red blood cells and white blood cells.

5. There will be a sense of burnout, resulting in the phenomenon of fatigue, and total cholesterol will also rise.

Precautions

1. When taking this product for a long time, it is necessary to check the liver functions such as GOT and GPT on time.

2. Since the safety of this product for pregnant women has not been determined, it is prohibited for pregnant women.

3. This product can be passed to breast milk, so breastfeeding women should use it with caution.

How to contact us?

Our company specializes in plant extracts, fruit and vegetable powders, cosmetics, tablet candies, and other products. It is a professional supplier. We have been engaged in this industry for many years and have rich experience and resources. If you want high-quality supply and low factory direct sales price, you can contact us through the international website or email.

Our email address is ella.zhang@huilinbio-tech.com, and you can also visit the factory through the company address, Room 706, Building B, Fengze Science, and Technology Park, No. 170 West Street, Yanta District, Xi'an City, Shaanxi Province. Now we are selling Idebenone powder hot, which is in stock; if you want to know its price, you can contact us through the above way, and we can give you a special price.