Product Description
Genistein Powder is planchisoflavin, this product is rectangular or hexagonal rod-shaped crystallization (60% ethanol), dendritic crystallization (ether), melting point 297-298℃ (slightly decomposed). Soluble in DMSO and ethanol, almost insoluble in water, the solubility in water is 8.7 MCG/ml, changing the solution pH has no significant effect on genistein. Genistein, mainly exists in legumes, such as locust horn, bean root content is larger.
Product Name | Genistein |
English name | Genistein |
CAS NO | 446-72-0 |
Product alias | 5,7,4 '-trihydroxyl isoflavone genistein Goldfins isoflavone |
Molecular formula | C15H10O5 |
Molecular weight | 270.23 |
Content | 98% |
Detection method | HPLC Product shape: light yellow powder crystal Light yellow crystalline powder; Soluble in common organic solvents, soluble in dilute alkali yellow. |
Product shape | light yellow powder crystal |
Product source | Rhizome of Genista tinctoria Linn, a leguminous plant |
Production process | Production process: mainly by alcohol extraction, extraction, crystallization and other processes completed |
Storage method | cool and dry, avoid light, avoid high temperature |
Shelf life | 2 years |
Function
1. Genistein and cardiovascular diseases. Genistein plays an important role in reducing the incidence of cardiovascular disease. The low density lipoprotein cholesterol in the blood is high and easy to be oxidized, which will cause atherosclerosis. Genistein can effectively reduce cholesterol, inhibit the oxidation of low density lipoprotein cholesterol (LDL), and keep the LDL level in the blood low, improve the abnormal peroxidation status caused by high fat, and alleviate the peroxidation damage to the body. Genistein can up-regulate the LDL receptor and increase the activity of the LDL receptor, thus promoting cholesterol clearance. Genistein can also inhibit the proliferation of smooth muscle cells, angiogenesis and cell adhesion, and reduce the incidence of cardiovascular diseases.
2. The effect of genistein on cerebral nerves. Genistein has the effect of promoting cerebral nerve regeneration and awakening of cerebral coma. According to modern medical theory, when stroke (cerebral hemorrhage) and stroke (cerebral infarction) occur, a series of pathophysiological changes such as ischemia and hypoxia, degeneration and necrosis of brain tissue cells are closely related to the influx of calcium ions outside the cells of brain tissue. The overload of calcium ions in brain cells is one of the main causes of degeneration and necrosis of brain cells. The latest research found that after changing the route of administration, genigeniin can cross the blood-brain barrier and protect brain cells during stroke (cerebral hemorrhage) and stroke (cerebral infarction) by affecting the cell membrane Ca++ receptor.
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3. Genistein Powder have radiation resistance.Genistein (genistein), a potent inhibitor of protein tyrosine kinase activity that also has antioxidant and estrogen-like effects, was identified by landauer et al., working at the U.S. Armed Forces Radiobiological Research Institute (AFRRI) laboratory, as a radiprotectant, Genistein significantly improved the 30-day survival rate of mice exposed to fatal traumatic brain injury at a total body irradiation dose (9.5Gy), either by subcutaneous injection 24 hours before irradiation or by gavage 4 days before irradiation or 4 days after irradiation.
4. Genistein and menopausal syndrome in women. Genistein has weak estrogen activity and the role of estrogen. Studies have shown that women's menopause, due to ovarian degeneration, estrogen reduction in the body, women will appear a series of menopausal syndrome symptoms, and the intake of quantitative genistein in menopause can supplement the lack of estrogen in the body, play a role in preventing and reducing women's menopausal syndrome. It is suggested that estrogen - like effect may be the main mechanism of genistein to prevent osteoporosis.
Preparation method
The solubility of genistein in water and aqueous solutions with different pH values was determined by thermodynamic solubility determination method. The effects of Poloxham F-68, sodium dodecyl sulfonate, hydrophilic polymer excipients PEG-6000, PVP K30 and hydroxypropyl β-cyclodextrin on its solubility were investigated.The permeability coefficient of genistein was measured in the small intestinal sac model of non-overturning rats, and the effects of different absorption promoters on its permeability were investigated. The effects of solubilizing and permeating agents on the activity of genistein in subacute aging mice induced by D-galactose were investigated.
Results: The solubility of genistein in water and different pH solutions was less than 18μg·ml-1, and the solubility of genistein was significantly improved by different concentrations of hydroxypropyl -β-cyclodextrin. The permeability coefficient of genistein in the small intestine of rats was 2·36×10-6cm·s-1, and different types of absorption accelerators could increase the permeability coefficient of genistein, and the absorption effect was as follows :0·5% sodium deoxycholate >0·5% sodium dodecyl sulfonate >0·5% ethylenediamine tetraacetate >0·5% Poloxam F-68>0·5% twain 80>0 ·5% carboxymethyl chitosan. The in vivo test results showed that the in vivo activity of genistein after solubilization was significantly different from that before solubilization, and the in vivo activity of genistein after solubilization and permeation was significantly different from that of genistein only after solubilization. Conclusion: Improving the absorption of genistein in small intestine based on solubility and permeability coefficient can improve its anti-aging activity in vivo.
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Our company is a professional supplier of semi-finished raw materials, including plant extract, fruit and vegetable powder, cosmetics, tablet candy and other kinds of products; Our products are supplied directly from the manufacturer, so the price is very favorable, and the quality is guaranteed, so you can rest assured to buy. Currently, our company is selling high-quality Genistein Powder, which is a high-quality additive material in health care products, medicine, skin care products and other products.
If you are interested in this product and want to know more about it, you can consult our account manager through the international website or email, our email address is ella.zhang@huilinbio-tech.com; Our factory is located in Room 706, Building B, Fengze Science Park, No.170 West Street, Yanta District, Xi 'an City, Shaanxi Province.