Product introduction
Kojic acid dipalmitate powder is a relatively new whitening raw material on the market. It is a derivative of kojic acid. Because of its good stability, good whitening effect, and no irritation to the skin, it has become the most popular in the whitening market. A new favorite, Kojic acid, is gradually eliminated by the market due to its poor stability and difficulty in compounding.
In the current cosmetic market, whitening cosmetics occupy half of the country, and whitening raw materials are constantly being introduced, so the effect of whitening cosmetics is becoming more efficient, safe, and cost-effective. The following chapter analyzes the difference between kojic acid and kojic acid dipalmitate in terms of their physical and chemical properties, stability, and whitening effect. Let me expand on them.
1. Differences in physical and chemical properties
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Kojic acid |
Kojic acid dipalmitate |
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CAS Number |
501-30-4 |
79725-98-7 |
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Molecular formula |
C6H6O4 |
C38H66O6 |
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Molecular Structure |
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Molecular weight |
142.11g/mol |
618.93g/mol |
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Physical and chemical properties |
White to slightly yellow crystalline powder, melting point is 150℃-154℃ |
White crystalline powder, melting point 92-96℃ |
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Solubility |
Easily soluble in water, ethanol, ethyl acetate |
Insoluble in water but soluble in oil, propylene glycol |
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Compound performance |
Due to potential hydrogen bonding in its molecular structure, this product is not compatible with some organic sunscreens and preservatives. |
It is compatible with most cosmetic ingredients and can be added to cosmetic products in combination with sunscreens. It is oil soluble, and kojic acid dipalmitate is more easily absorbed by the skin when added to creams than kojic acid. |
Kojic acid, a metabolite of Aspergillus oryae, was first discovered in the brewing industry. Later, a substance with a whitening effect, kojic acid, was found in the soy sauce brewed by Aspergillus oryae. Its production process is as follows: firstly inoculate Aspergillus oryzae in a culture medium composed of glucose at a temperature of 30-32 degrees Celsius, and then ferment for 5-6 days to obtain a crude product; then filter, concentrate, extract, and other steps of the natural product, After that, it is treated with activated carbon, extracted and crystallized to obtain kojic acid.
Since kojic acid dipalmitate is a kojic acid derivative, its production process is also somewhat related to kojic acid. The specific steps are first to mix palmitic acid and phosphorus trichloride to obtain palmitoyl chloride, and then add kojic acid material can be obtained.
2. In terms of stability
Kojic acid has a good effect on inhibiting tyrosinase activity and melanin production. It is an excellent whitening raw material and can be used in cosmetic formulations to remove freckles, age spots, pregnancy spots, pigmentation, and other products.
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Kojic acid has an excellent cosmetic effect, but it is rarely used in products due to its instability. Its disadvantage is that it is susceptible to light and heat and quickly oxidizes in the air. In terms of color: it reacts with many metal ions, such as ferric ions, which will make the formulated skin whitening product gradually turn yellowish brown during use; from the PH value, when the PH value is >7, When kojic acid is above 40°C, it will be unstable, and finally, it will be unstable when kojic acid is above 40°C, and a cream containing 1% kojic acid will turn yellowish when placed at 45°C for four weeks to brown.
However, since kojic acid dipalmitate powder completely overcomes these shortcomings of kojic acid, it has excellent stability in the formulation. At the same time, it will not produce chemical reactions with other ingredients in cosmetics, and reduce the difficulty of the formulation. In the cosmetic preparation process, when the oil phase is heated to 75°C-85°C, the product can be well melted into the oil phase and then emulsified, which is convenient for preparation.
3. The difference between the two in the whitening effect
According to the experiment, the whitening effect of kojic acid and kojic acid dipalmitate is shown in the figure below. The Y-axis in the figure represents the absorption capacity of a 475nm light wave. By detecting the color of various melanin intermediates, tyrosinase activity is displayed. The x-axis is the elapsed time from when tyrosinase was added to the medium. The experimental results showed that the group of experiments that added kojic acid recovered its tyrosinase activity at 5 minutes, while the group of experiments with kojic acid dipalmitate only slowed down tyrosinase at 12 minutes. Slow to show its movement. In addition, these two substances have also been clinically tested on people with pigmented diseases. The results showed that the effective rates of kojic acid and kojic acid dipalmitate were 60%-95% and 80%, respectively.
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It can be seen that the whitening effect of kojic acid dipalmitate is better than that of kojic acid. In addition, since kojic acid dipalmitate has good fat solubility, it can be more easily absorbed and utilized by the skin, and it is also an excellent moisturizing agent.
Common points of kojic acid and kojic acid dipalmitate
Source: kojic acid and kojic acid dipalmitate can be extracted from natural plants or synthesized. Kojic acid mainly exists in some fruits, such as blueberry and pomegranate, and kojic acid dipalmitate is obtained by the chemical reaction between kojic acid and palmitic acid.
Oxidation resistance: kojic acid and kojic acid dipalmitate have certain oxidation resistance. They can help prevent the generation of free radicals and oxidation reactions, and have a certain role in protecting cells from oxidative damage.
Application: kojic acid and kojic acid dipalmitate have similar applications in some fields. For example, they can be used in food industry as food additives to increase the safety and preservation effect of food.
How to contact us?
Our company has many years of sales experience in the plant extract industry, has many high-quality products, and is a professional Kojic acid dipalmitate powder supplier. Besides, our products are direct from the factory, not only cheap but also high quality. Our company sells the above products, and there will be great discounts if you buy in large quantities. If you are interested, you can contact us.
Our contact is: first, contact us through the international website or email; our email is ella.zhang@huilinbio-tech.com; our account manager will reply as soon as you see the news. Second, you can visit Room 706, Block B, Fengze Science, and Technology Park, No. 170 West Street, Yanta District, Xi'an City, Shaanxi Province.