Geniposide Powder

Geniposide powder is a high-purity iridoid glycoside compound extracted from the dried fruits of Gardenia jasminoides. This specialized Gardenia extract supplement contains a standardized geniposide structure classified as an iridoid glycoside, with documented bioactivity in PubChem (CID: 107848). With a geniposide molecular weight of 388.37 g/mol and a favorable geniposide solubility profile (freely soluble in water and ethanol), this versatile compound offers significant potential in metabolic health support and neuroprotection. Current research particularly highlights its promising role as a natural GLP-1 activator, making it increasingly valuable for metabolic syndrome management.

Chemical & Physical Properties：
As a naturally occurring iridoid glycoside, the geniposide structure exhibits characteristic properties that contribute to its diverse biological activities. The compound displays positive reactions with α-naphthol, hydroxamic acid, and ferric chloride, confirming its chemical identity. The moderate geniposide molecular weight of 388.37 g/mol contributes to its excellent geniposide solubility in both aqueous and ethanolic solutions, enhancing its formulation flexibility for various applications.

Metabolic Health Benefits

• Functions as a natural GLP-1 activator, supporting glucose-dependent insulin secretion
• Demonstrates potential in supporting pancreatic beta-cell function and proliferation
• Shows lipid metabolism regulation properties in preclinical studies
• May support weight management through metabolic pathway modulation

Neuroprotective Benefits

• Acts as a potent neuroprotective compound with demonstrated blood-brain barrier permeability
• Supports cognitive function through multiple mechanisms including antioxidant activity
• Shows potential in memory enhancement and learning capacity improvement
• Demonstrates protective effects against neuronal damage in experimental models

Hepatoprotective & Anti-inflammatory Benefits

• Supports liver health through detoxification pathway enhancement
• Geniposidic acid metabolites contribute to anti-inflammatory effects
• Demonstrates cholagogic effects supporting bile production and flow
• Shows protective effects against chemical-induced liver damage

Cardiovascular Benefits

• Exhibits hypotensive properties through multiple mechanisms
• Demonstrates vasodilatory effects and improved endothelial function
• Shows potential in reducing cardiovascular risk factors

• Pharmaceutical Formulations: 50-200 mg per unit dose
• Dietary Supplements: 100-300 mg daily as a Gardenia extract supplement
• Cosmetic Applications: 0.5-2.0% in final formulations
• Research Use: Varies by experimental design and target pathways

1. Crushing of raw leaves: The dried leaves of Eucommia ulmoides Oliv., the water content of which is less than or equal to 14%, are crushed by conventional methods and sieved by 80 meshes.
2. Enzymatic-assisted extraction of medium-warm water: add a certain amount of water to the crushed raw leaves, adjust the pH to 4.5, keep the temperature constant to 50℃ ~ 60℃, and add a proper amount of cellulase for extraction under the following conditions: the addition amount of cellulase is 0.2% of the substrate concentration, that is, 0.002 kg of cellulase is consumed per kilogram of raw leaves, and the mass ratio of Eucommia ulmoides leaves to water is 1: 12, and extraction is 2.
3. Filtration: After the two extracts are combined, impurities such as suspended solids are removed by conventional filtration.
4. Impurity removal by ultrafiltration membrane: The water extract of Eucommia ulmoides leaves is treated by ultrafiltration membrane with a filtration aperture of 0.02 ~ 0.0.06 μ m, which can intercept almost all impurities such as macromolecular protein and polysaccharide, while geniposide can be completely permeated with a molecular weight of about 400Dal. The operating conditions of the membrane are p = 0.2 ~ 0.6 MPa, t = 30 ~ 50℃, and pH =.
5. Nanofiltration concentration: The nanofiltration membrane with a molecular weight of 200-400 dal is adopted to concentrate the filtrate of the primary membrane, and the filtrate can be partially desalted. The concentration multiple of this membrane can reach more than 15 times, and the removal rate of inorganic salt ions can reach 60%. The operating strips of the membrane are: p = 1.0 ~ 1.5 MPa, t = 30 ~ 60℃, pH = 4 ~ 5, and Q = 20L/min.
6. Separation and purification of macroporous resin: the concentrated solution of the nanofiltration membrane is adsorbed and eluted by macroporous resin. First, the impurities are removed by pure water with twice the volume of resin, then eluted by 70% ethanol with 2.5 times the volume of the resin column, and the ethanol eluate is collected.
7. Concentration and drying: The collected ethanol eluent can be concentrated under conventional reduced pressure and dried in a vacuum to obtain geniposide powder.

Large cargo is 25kg, packed in cardboard drums, and the drum weighs 2.5-3kg. It can be divided into small packages according to customer needs. The sample 1kg is sealed in aluminum foil bags.

Mode of transportation: express, sea, air

Express company: DHL/FEDEX/TNT/EMS/UPS, etc.

The company's products are reviewed in accordance with the production process indicators of the National Pharmacopoeia, and the quality of the products is strictly controlled. It is equipped with processing equipment such as subcritical extraction and supercritical extraction. The products are tested before they leave the factory before they can be sold in the warehouse.

The company is located in the National High-tech Industrial Development Zone in Xi'an, China. It is an enterprise dedicated to the production and sales of animal and plant extracts, pharmaceutical intermediates, cosmetic raw materials, health raw materials, etc. The products are exported to the European Union, the United States, Japan, and Southeast Asia. We welcome friends from all over the world to come to consult and cooperate.

The company promises that the products sold are all genuine products with qualified quality and purity standards. We look forward to establishing a cooperative relationship with you. Contact email: ella.zhang@huilinbio-tech.com

Why choose us?

• Our Natural Ingredients are safe and compliant with all regulations and standards.
• We respect the dominant position and pioneering spirit of employees, believe in and rely on employees.
• Our team is skilled and knowledgeable in all aspects of Natural Ingredients manufacturing.
• Our company is a modern enterprise integrating manufacturing, production, and sales. After years of development, the company has always adhered to the principle of "innovation, quality, service, dedication, and gratitude", constantly improving services, and insisting on making high-quality products. Our products are well received by domestic and foreign customers.
• We have a wide range of Natural Ingredients available to choose from.
• Customer expectation is actually the most basic service required by customers, followed by advanced service requirements.
• We understand the importance of using only the best quality materials in our products.
• Our company is a modern enterprise specializing in production and sales. We have modern workshops and high-precision equipment and molds. We are a manufacturer of several series of various products. In addition, we have also introduced advanced automation equipment to efficiently produce green products that meet international quality certification.
• Our Natural Ingredients are used in many industries, from cosmetics to food and beverage.
• We always focus on product development and technological innovation, and design our Geniposide Powder with scientific and stable concepts.

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