Luteolin 95% / 98% | High-Purity Flavonoid for Neuroinflammation Research & Nutraceutical Applications
Product Overview: A Multi-Target Bioactive Flavonoid
Our Luteolin is a high-purity, natural flavonoid offered in 95% and 98% specifications to meet diverse formulation needs. Renowned for its potent multi-target biological activities, this ingredient is increasingly vital for advanced nutraceutical, cosmetic, and pharmaceutical research applications. Its ability to interact with multiple key cellular pathways makes it a superior choice for innovative health product development.
Product Specification
| Parameter | Specification |
|---|---|
| Product Name | Luteolin |
| CAS Number | 491-70-3 |
| Purity | 95% / 98% (HPLC) |
| Appearance | Fine yellow powder |
| Mesh Size | 100% through 80 mesh |
| Loss on Drying | ≤ 5.0% |
| Heavy Metals (Total) | ≤ 10.0 mg/kg |
| Lead (Pb) | ≤ 3.0 mg/kg |
| Total Plate Count | ≤ 1000 CFU/g |
| Yeast & Mold | ≤ 100 CFU/g |
| Storage | Keep in a cool, dry, and well-ventilated place. Protect from light. |
Mechanisms of Action
The therapeutic potential of Luteolin is grounded in its sophisticated, multi-mechanistic actions at the cellular and molecular level.
1. Potent Anti-inflammatory Action via NF-κB Pathway Inhibition
Luteolin exerts powerful anti-inflammatory effects primarily by inhibiting the Nuclear Factor Kappa-B (NF-κB) signaling pathway, a master regulator of inflammation. It achieves this by blocking the activation of IκB kinase (IKK), thereby preventing the degradation of IκBα, an inhibitory protein that keeps NF-κB sequestered in the cytoplasm. This inhibition stops the translocation of NF-κB to the nucleus, effectively suppressing the expression of pro-inflammatory genes such as TNF-α, IL-6, and COX-2 [1]. This mechanism is crucial for modulating chronic inflammation linked to various health conditions.
2. Dual Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX) Inhibition
Beyond upstream NF-κB inhibition, Luteolin directly targets key enzymes in the inflammatory cascade. It acts as a natural COX-2 inhibitor, reducing the production of prostaglandins that mediate pain and swelling. Concurrently, it inhibits 5-lipoxygenase (5-LOX), decreasing the synthesis of leukotrienes. This dual inhibition of both the COX and LOX pathways provides a broader and more balanced anti-inflammatory effect compared to synthetic drugs that typically target only one pathway [2].
3. Enhanced Antioxidant Defense via Nrf2 Pathway Activation
Luteolin is a powerful activator of the Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, the body's primary defense mechanism against oxidative stress. Under normal conditions, Nrf2 is bound to Keap1 in the cytoplasm and targeted for degradation. Luteolin modifies Keap1, freeing Nrf2, which then translocates to the nucleus. There, it binds to the Antioxidant Response Element (ARE), initiating the transcription of a battery of cytoprotective genes, including those for glutathione, superoxide dismutase (SOD), and heme oxygenase-1 (HO-1). This significantly enhances the cell's endogenous antioxidant capacity [3].
Key Health Benefits & Research Applications
Brain Health & Neuroprotection: By crossing the blood-brain barrier and suppressing microglia-mediated neuroinflammation via the above mechanisms, Luteolin is a key ingredient for cognitive support, mood balance, and neuroprotection formulations.
Systemic Anti-Inflammatory Support: Ideal for products targeting joint health, metabolic wellness, and managing chronic, low-grade inflammation.
Skin Health & Antioxidant Protection: Its Nrf2-activating and anti-inflammatory properties make it highly effective in cosmeceuticals for soothing irritated skin, combating oxidative stress from UV exposure, and supporting anti-aging.
Immune System Modulation: Helps balance immune responses by fine-tuning the production of inflammatory cytokines.
Targeted Application Areas
Dietary Supplements: Cognitive health, joint support, systemic antioxidant, and comprehensive wellness formulas.
Cosmeceuticals: Anti-aging serums, soothing creams, and protective lotions.
Functional Foods & Beverages: Fortified health drinks and foods for inflammation management.
Pharmaceutical Research: Drug discovery for inflammatory and neurological disorders.
Frequently Asked Questions (FAQ
Q: What is the difference between 95% and 98% purity?
A: The 98% purity is recommended for high-potency applications and pharmaceutical research where maximum activity and minimal impurities are critical. The 95% grade offers a cost-effective solution for standard dietary supplements and cosmetic products.
Q: What documentation do you provide?
A: We supply a comprehensive Certificate of Analysis (COA) for each batch, including HPLC purity, heavy metals, microbial limits, and residual solvent analysis.
Q: Can Luteolin be combined with other ingredients?
A: Yes, it exhibits excellent synergistic effects with other flavonoids like Quercetin, Fisetin, and Curcumin, creating a broader spectrum of action.
Q: What is your minimum order quantity (MOQ)?
A: Our MOQ starts at 1 kilogram, with sample quantities available for qualified buyers.
Company Introduction
Xi'an Huilin Bio-tech Co., Ltd. is a leading provider of premium plant extracts for health applications. We supply herb extracts, standardized extracts, and fruit/vegetable powders. Dedicated to quality and innovation, we serve global customers in the supplements, food, and cosmetic industries, advancing human health. Click here to learn more.
OME/oDM service
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How To Contact Us?
If you need this organic luteolin powder, please get in touch with us at ella.zhang@huilinbio-tech.com.
References
[1] Kim, J. S., & Jobin, C. (2005). The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IκB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells. Immunology, 115(3), 375-387. https://pubmed.ncbi.nlm.nih.gov/15946255/
[2] Lopez-Lazaro, M. (2009). Distribution and biological activities of the flavonoid luteolin. Mini Reviews in Medicinal Chemistry, 9(1), 31-59. https://pubmed.ncbi.nlm.nih.gov/19149659/
[3] Tang, X., Wang, H., Fan, L., Wu, X., Xin, A., Ren, H., & Wang, X. J. (2011). Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs. Free Radical Biology and Medicine, 50(11), 1599-1609. https://pubmed.ncbi.nlm.nih.gov/21402146/
Xi'an Huilin BioTech | Specialized in Plant Extract Ingredients Since 2006
Why choose us?
- We use eco-friendly production processes to ensure that our Standardized Extract products are environmentally sustainable.
- Our philosophy is: customer success is our success. We will provide high cost performance, high quality products to our customers to help customers achieve market breakthroughs.
- Our factory has a robust supply chain management system that facilitates smooth and efficient production and delivery processes.
- Our continuous development and innovation concept is the direction of the enterprise forward.
- Our team of professionals is committed to ensuring that every product we produce meets the highest standards of quality and safety.
- Since the founding of our company, with the support and care of our customers, our company has continuously improved enterprise management and optimized product quality.
- We maintain complete transparency in all our business dealings.
- We have established a high-efficiency and high-quality product scientific research team, giving full play to the advantages of each department's cooperation, taking the company's overall strategy as a guide.
- Our Standardized Extracts are produced from natural ingredients and are free from harmful chemicals.
- We will continue to be responsible for our products, markets, channels and customers, as well as launching new series of Luteolin Powder.
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