Product Information
Hesperidin is a major flavanone glycoside belonging to the vitamin P class of compounds. It is abundantly found in the peels, membranes, and albedo (white spongy part) of citrus fruits, with sweet orange (Citrus sinensis) being a primary source.
In its natural state, hesperidin exists as a glycoside, meaning its active aglycone (hesperetin) is bound to a sugar molecule (rutinose). This structure is key to its properties and bioavailability. Beyond its well-established role in supporting cardiovascular and capillary health, modern scientific research has unveiled its promising potential in neuroprotection and cognitive support.
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Basic Parameters
The table below lists the key physical and chemical properties of Hesperidin powder, essential for quality control, formulation, and regulatory documentation.
| Parameter | Value / Description |
|---|---|
| Melting Point | 250 - 255 °C (with decomposition) |
| Optical Rotation | -76° (c=2 in pyridine) |
| Solubility | Very low in water. Sparingly soluble in methanol; soluble in dimethyl sulfoxide (DMSO) and pyridine. |
| Acidity (pKa) | ~7.15 |
| LogP (Octanol-Water) | ~0.3 at 25°C |
| Storage Conditions | Sealed in a dry container at 2-8°C |
| Hygroscopicity | Slightly hygroscopic |
Mechanism of Action
Hesperidin's broad-spectrum benefits are primarily mediated through its potent and synergistic biological activities:
- Antioxidant Defense: Hesperidin is a powerful free radical scavenger. It directly neutralizes reactive oxygen species (ROS) and upregulates the body's intrinsic antioxidant defense enzymes, thereby reducing oxidative stress-a root cause of cellular aging and numerous chronic conditions.
- Anti-inflammatory Modulation: It exerts significant anti-inflammatory effects by inhibiting key pro-inflammatory enzymes (like cyclooxygenase and lipoxygenase) and suppressing the production of inflammatory cytokines (such as TNF-α and IL-6). This mechanism was confirmed in vivo as early as 1994.
- Neuroprotective Pathways: Preclinical reviews highlight hesperidin's role in brain health. Its neuroprotective effects are linked to modulating neural growth factors, reducing neuroinflammation, and inhibiting apoptotic pathways in neurons, showing promise for managing brain disorders.
- Vascular System Support: Hesperidin strengthens blood capillaries by reducing permeability and fragility. It is a primary component of Vitamin P (permeability vitamin), which supports microcirculation and vascular integrity.
Key Benefits and Advantages
Incorporating our high-purity Hesperidin Powder into your products offers compelling market advantages:
- Science-Backed Health Support: Supported by decades of research for cardiovascular, cognitive, and anti-inflammatory benefits, providing strong claims for nutraceutical products.
- Dual-Form Versatility: Can be used directly as a water-soluble glycoside (hesperidin) or processed into its more bioavailable aglycone form (hesperetin) for enhanced efficacy in certain applications.
- Natural and Sustainable Sourcing: Derived from upcycled citrus peels, a by-product of the juice industry, promoting an eco-friendly and sustainable supply chain.
- Excellent Safety Profile: Classified as a Generally Recognized As Safe (GRAS) flavor enhancer by the FDA's FEMA program and widely used globally.
- Synergistic Formulation Potential: Works exceptionally well with other bioflavonoids like diosmin (to which it can be converted) and vitamin C, creating powerful synergistic formulations for vein and antioxidant support.
Primary Applications
| Industry | Application Examples | Functional Role & Benefit |
|---|---|---|
| Nutraceuticals & Dietary Supplements | Capsules, tablets, powder blends. Often combined with Diosmin for vein health. | Provides core antioxidant and vascular support. Used in formulas for circulatory health, cognitive support, and general wellness. |
| Functional Food & Beverage | Fortified juices, health drinks, dairy products, snack bars. | Used as a natural functional ingredient to add health-promoting value. Approved as a flavor enhancer. |
| Cosmetics & Skincare | Anti-aging serums, creams, lotions, and protective formulations. | Acts as a potent antioxidant to protect skin from free radical damage and UV-induced stress. Supports collagen synthesis and reduces inflammation. |
| Pharmaceutical Intermediates | Synthesis of other valuable flavonoids and drugs. | Serves as a key starting material for the semi-synthesis of Diosmin and other specialized flavonoid derivatives. |
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Comparison: Hesperidin vs. Diosmin
A common question concerns the difference and relationship between Hesperidin and Diosmin. The following table clarifies:
| Feature | Hesperidin | Diosmin |
|---|---|---|
| Chemical Form | Flavanone Glycoside (Hesperetin + Rutinose). | Flavanone Glycoside (Diosmetin + Rutinose). |
| Primary Natural Source | Abundant in citrus peels. | Less abundant in nature; often commercially produced from hesperidin. |
| Key Application | Broad-spectrum antioxidant, neuroprotective, general vascular support. | Specifically renowned for venous insufficiency (e.g., varicose veins, hemorrhoids). Often used in combination with Hesperidin for enhanced effect. |
| Relationship | Precursor. Diosmin can be synthesized from hesperidin through a dehydrogenation process. | Derivative. |
Frequently Asked Questions (FAQ)
Q: What are the main health benefits of taking a Hesperidin supplement?
A: Based on scientific research, Hesperidin supplements are primarily used to support antioxidant defense, reduce inflammation, promote healthy circulation and capillary strength, and show promising potential for brain and cognitive health.
Q: Are there any side effects of Hesperidin?
A: Hesperidin is generally well-tolerated at recommended dosages. High intakes may cause mild gastrointestinal discomfort in some individuals. It is always advised to consult a healthcare professional before starting any new supplement.
Q: What is a typical dosage for Hesperidin?
A: Dosage varies by application. In dietary supplements for general health, common doses range from 250 mg to 500 mg per day. For specific formulations like vein health complexes, it is often combined with Diosmin (e.g., 450 mg Diosmin + 50 mg Hesperidin). Always follow the dosage on the product label.
Q: Can Hesperidin aid in weight loss?
A: While not a primary weight-loss agent, some preclinical studies suggest it may influence metabolism and support factors related to metabolic syndrome. However, more human clinical research is needed to substantiate direct effects on weight loss.
Q: Which foods are high in Hesperidin?
A: Hesperidin is concentrated in the white pith and peel of citrus fruits (oranges, lemons, grapefruits). Eating whole fruits (including the membrane) provides more hesperidin than drinking filtered juice.
Q: What is Hesperidin Methyl Chalcone?
A: This is a synthetic, water-soluble derivative of hesperidin. The "methyl chalcone" form is created to significantly improve solubility, making it a preferred form for certain liquid formulations and cosmetic applications.
What Can We Bring You?
We can provide OEM, ODM services.
We have a third-party inspection and certification certificate, and the quality can be guaranteed.
We can integrate production and service. We have our own factories and independent laboratories
We can customize products, such as capsules or compressed candies.
We have a variety of logistics transportation methods and can provide you with multiple logistics channels.
Our material quality testing is in line with BP and USP.
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What Is The Corporate Culture Of Our Company?
We, Xi'an Huilin Biological Technology Co., Ltd., are a comprehensive trader with a wealth of experience in the business for about 10 years. With its own factory and independent laboratory, it can provide a one-stop production service and can strictly control the quality of products. We have experienced sales staff who can provide you with good after-sales service in a timely and professional manner. Our company adheres to the principle of service-oriented, quality first, and provides you with high-quality products and satisfactory after-sales service.
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Contact Us
If you are interested in purchasing our products, you can contact us by email: ella.zhang@huilinbio-tech.com, we sincerely look forward to cooperating with you.
Why choose us?
- We provide complete technical support to our clients, ensuring that their queries are resolved promptly and efficiently.
- We have responded positively to national policies, further promoted corporate governance in accordance with the law, and strengthened compliance construction.
- Our products are packed with care using superior quality packaging materials to ensure their safety during transportation.
- Our company currently has many excellent talents, mature market channels, and a good corporate reputation. In the future, we will wholeheartedly provide customers with excellent products and services with competitive prices.
- We believe in delivering customer satisfaction through quality products and services.
- For important positions, our company has a succession plan to ensure sufficient talent reserve.
- At our factory, we produce premium-quality Standardized Extracts that meet international standards.
- Our company combines international advanced technology, constantly exploring in practice, and has always been in a leading position in Citrus Aurantium Extract Powder industry.
- We are committed to continuous research and development to ensure that our products remain innovative and up-to-date.
- The company attaches great importance to product quality and strictly controls the quality.
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