Bergenin Powder

Bergenin Powder is a high-purity, naturally occurring isocoumarin compound and bioactive C-glucoside extracted primarily from plants of the Saxifragaceae family, notably various Bergenia species such as Bergenia purpurascens. This white crystalline powder is renowned for its diverse pharmacological activities and serves as a valuable reference standard and active ingredient for research and development across pharmaceutical, nutraceutical, and cosmetic industries.

Bergenin is a secondary metabolite named after the Bergenia genus. It has been isolated from a wide range of plant species (over 112 species across 34 families), with significant concentrations found in Bergenia crassifolia, Bergenia ciliata, and Rodgersia sambucifolia.

In traditional medicinal systems, plants rich in bergenin, particularly in Central and East Asia, have been used for centuries. Traditional applications include treating cough and pulmonary diseases, stopping bleeding, boosting immunity, and dissolving kidney stones. In China, bergenin is an officially recognized compound used in preparations for chronic bronchitis.

Extensive preclinical research has identified a broad spectrum of biological activities associated with bergenin. Notably, studies indicate it exhibits no cytotoxicity toward healthy cells. Its mechanisms and potential benefits are multifaceted:

• Antioxidant & Anti-inflammatory: Bergenin is a potent antioxidant that scavenges free radicals and modulates key inflammatory pathways like NF-κB and NLRP3 inflammasome, reducing the expression of pro-inflammatory cytokines. This forms the basis for many of its other observed effects.
• Metabolic & Organ Protection: Research suggests bergenin may help regulate glucose and lipid metabolism, offering potential in metabolic syndrome research. It also shows hepatoprotective (liver) and nephroprotective (kidney) effects in models of injury, linked to its anti-oxidative and anti-apoptotic properties.
• Neuroprotective Activity: Studies indicate bergenin may support cognitive function and offer protection in models of neurological disorders by inhibiting acetylcholinesterase and reducing oxidative stress in neural tissue.
• Research in Oncology: In vitro and in vivo studies highlight bergenin's role in investigating anticancer mechanisms. It has been observed to inhibit proliferation, induce cell cycle arrest, and promote apoptosis in various human cancer cell lines by modulating pathways like PI3K/AKT and STAT3. This research is preclinical and foundational for future therapeutic development.

Our high-purity Bergenin Powder is suitable for diverse applications, with specifications tailored for each sector.

1. Pharmaceutical Research & Development

• Reference Standard: Used as a high-purity analytical standard (HPLC, LC-MS) for quality control of herbal medicines and botanical extracts.
• Pharmacological Studies: Employed in preclinical in vitro and in vivo research to investigate its mechanisms of action, pharmacokinetics, and potential therapeutic efficacy for various conditions.
• Drug Discovery: Serves as a lead compound or precursor for the synthesis of novel derivatives with enhanced biological activity.

2. Cosmetic & Skincare Formulations

• Anti-Aging & Protective Agent: Incorporated for its strong antioxidant properties to protect skin from oxidative stress caused by UV and environmental pollutants.
• Soothing & Brightening Ingredient: Its anti-inflammatory activity helps calm irritated skin, while studies suggest it may inhibit tyrosinase, contributing to skin-brightening effects.

3. Nutraceuticals & Functional Foods

• Dietary Supplement Research: Used in developing supplements focused on antioxidant support, liver health, and inflammatory response modulation. Consumer interest in bergenin supplements is growing alongside research.
• Functional Food Additive: Can be explored as a bioactive ingredient in health-oriented food products, given its natural origin and safety profile.

• Quality Assurance: Every batch is rigorously analyzed using HPLC-DAD/ELSD and identified by advanced techniques like Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) to ensure identity, purity, and consistency.
• Safety Profile: A comprehensive 2023 scientific review noted that extensive studies on bergenin and its derivatives "showed no cytotoxicity for healthy cells". It is well-tolerated in traditional use and preclinical research.
• Regulatory Status:

 For pharmaceutical research, it is supplied as a reference standard or bulk active pharmaceutical ingredient (API) for investigational use.

 For cosmetic and nutraceutical applications, it is the responsibility of the final product manufacturer to ensure compliance with local regulations (e.g., FDA, EU Cosmetics Regulation, etc.).

 In China, bergenin is an approved medicinal compound included in drug preparations.

Each batch of the company's goods has undergone strict testing. If the tested content or colony is unqualified when the goods are received, you can contact us for consultation, and it can be tested by authoritative testing agencies recognized by both parties. If the product quality is confirmed to be defective, we will provide a free return.

We provide customized services to meet the different needs of customers:

◇ Product customization services of different specifications.

◇ Provide powder processing services. Such as powder canned capsules, powder compressed tablets, and so on.

◇ Customized service of the outer packaging, such as ziplock bag packaging, and bottled packaging. Carton packaging, etc., and special packaging require customers to provide design materials.

Large cargo 25kg/cardboard drum, sample packaging is aluminum foil bag 1kg/bag, unified label: product name, specifications, etc., please contact customer service for other needs

Transportation by sea, express, air, and other methods (express and air are safe and fast, and sea freight is economical)

The company uses animals and plants as raw materials, through physical and chemical purification, without changing the structure of the effective ingredients, and directionally obtains the effective ingredients from plants, and finally obtains vegetable oils, extracts, powders, lenses, etc. The categories include animal and plant extracts, medicines and health products, cosmetic raw materials, etc., which are produced in strict accordance with GMP standards and are committed to providing customers with the highest quality products.

After confirming with good related products information and orders, we will send a proforma invoice to you, or you can get it from Alibaba online trade.

100% payment before shipment, you can choose a convenient payment method.

We offer a variety of payment methods, including bank transfer, Escrow, PayPal, Western Union, and MoneyGram. You can choose which one.

Our company is a professional supplier of semi-finished materials, including plant extracts, fruit and vegetable powder, cosmetics, tablet candy, and other products. Our products are directly supplied from the manufacturer, so the price is very favorable, and the quality is guaranteed, so that you can buy with confidence.

Now our company is hot-selling high-quality bergenin powder. If you are interested in this product and want to know about it, you can consult our account manager through the international website or email. Our email address is ella.zhang@huilinbio-tech.com.

Why choose us?

• As a reputable manufacturer and supplier, we take pride in delivering exceptional products and services.
• We are well aware that only our Bergenin Powder with superb technology and quality can win the praise of our customers.
• Customers can rely on us for high-quality Standardized Extracts at competitive prices.
• In our view, quality is an attitude. We know that quality cannot stop at providing well-made products, but also exceed customer expectations.
• We strive to be a reliable partner to our clients by delivering exceptional products and services.
• Our staffs are rich in experience and trained strictly, with qualified knowledge, with energy and always respect their customers as the No.
• We believe in delivering value to our clients through quality products and competitive pricing.
• We are clear about our new goals, and we are working together to push our business to a new peak with high and full passion in front of opportunities and challenges.
• We take pride in maintaining a consistent quality in our Standardized Extract products.
• The company has professional research institutes, design and manufacturing centers and Bergenin Powder production bases, with strong research and development capabilities and exquisite craftsmanship

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