Product information
Gypenosides Powder is a highly concentrated, standardized extract derived from Gynostemma pentaphyllum, a climbing vine revered in traditional herbal systems as "Jiaogulan" or "Southern Ginseng." This nickname stems from its rich content of gypenosides-triterpenoid saponins that are structurally analogous to, and in some cases identical with, the prized ginsenosides found in Panax ginseng. Our extract isolates these potent bioactive compounds, offering manufacturers a powerful, research-backed ingredient to formulate products targeting metabolic health, cardiovascular wellness, stress resilience, and healthy aging. Available in a wide range of potencies, it provides unparalleled flexibility for product development.
Basic parameters
| Parameter | Specification / Description |
|---|---|
| Product Name | Gypenosides Powder (Gynostemma Extract) |
| Botanical Source | Whole herb of Gynostemma pentaphyllum (Thunb.) Makino |
| Part Used | Aerial parts (leaf and stem) |
| Extraction Method | Ethanol/Water extraction, followed by purification and concentration. |
| Active Marker | Total Gypenosides (HPLC) |
| Available Potency | 10%, 20%, 40%, 80%, 90%, 95%, 98% (Custom standardization available) |
| Appearance | Fine, free-flowing brown-yellow powder; characteristic herbal odor. |
| Particle Size | 100% through 80 mesh |
| Loss on Drying | ≤ 5.0% |
| Heavy Metals | ≤ 10 ppm (As, Pb, Cd, Hg) |
| Microbiological | Total Plate Count ≤ 1000 CFU/g; Complies with food-grade standards. |
| Solubility | Highly soluble in water and hydro-alcoholic solutions. |
Mechanism of Action: Multi-Target Bioactivity
The benefits of gypenosides are attributed to their remarkable structural diversity, enabling interaction with multiple biological pathways. Unlike single-target agents, gypenosides exert pleiotropic effects:
1. Adaptogenic & Metabolic Master Regulator (AMPK Activation): Gypenosides are potent activators of AMP-activated protein kinase (AMPK), a cellular energy sensor often called the "metabolic master switch." Activating AMPK mimics the effects of exercise and caloric restriction, promoting cellular energy production (glucose uptake, fatty acid oxidation) and inhibiting anabolic processes like fat and cholesterol synthesis. This central mechanism underpins its support for metabolic health.
2. Antioxidant & Anti-inflammatory (Nrf2 & NF-κB Pathways):
- Nrf2 Pathway: Gypenosides upregulate the Nrf2 signaling pathway, enhancing the expression of endogenous antioxidant enzymes (e.g., SOD, glutathione).
- NF-κB Pathway: They inhibit the NF-κB inflammatory pathway, reducing the production of pro-inflammatory cytokines (e.g., TNF-α, IL-6). This dual action mitigates oxidative stress and chronic low-grade inflammation.
3. Cardiovascular & Endothelial Protection: Gypenosides help maintain vascular health by supporting nitric oxide (NO) production for vasodilation, inhibiting vascular smooth muscle cell proliferation, and modulating lipid profiles.
4. Neuroprotection (BDNF & SIRT1): Research indicates gypenosides can increase Brain-Derived Neurotrophic Factor (BDNF) levels and modulate SIRT1 activity, supporting neuronal survival, synaptic plasticity, and cognitive function-pathways linked to brain aging.
Key Benefits & Supported Health Areas
Based on in vitro, in vivo, and human clinical studies, Gypenosides Powder is associated with the following areas of health support:
- Metabolic Syndrome & Blood Sugar Balance: By activating AMPK, it supports healthy insulin sensitivity, glucose metabolism, and lipid profiles, aiding in the management of metabolic health.
- Cardiovascular Wellness: Contributes to maintaining healthy blood pressure within normal range, supporting endothelial function, and promoting a balanced cholesterol profile.
- Hepatoprotection (Liver Support): Demonstrates protective effects against liver injury from toxins and metabolic stress by reducing inflammation and fat accumulation in hepatic cells.
- Adaptogenic & Anti-fatigue Effects: Helps the body adapt to physical and mental stress, improves exercise endurance, and reduces sensations of fatigue by optimizing energy metabolism.
- Neuroprotection & Cognitive Support: Its antioxidant and BDNF-enhancing properties suggest potential in supporting memory, focus, and protecting against age-related cognitive decline.
- Skin Health (Cosmetic Applications): When applied topically, its anti-inflammatory and antioxidant properties help soothe irritated skin, protect against environmental damage, and may support skin barrier function.
Primary Application Fields
1. Functional Foods & Beverages:
- Solid Beverages: Instant health drink mixes, sachets.
- Functional Teas: Blended into Jiaogulan tea products or herbal tea blends.
- Enhanced Waters & Shots: For metabolic or energy support.
2. Dietary Supplements & Nutraceuticals:
- Capsules & Tablets: As a standalone ingredient or in complexes for metabolic, cardiovascular, or liver health.
- Powder Blends: Added to superfood or green powder formulations.
3. Cosmetics & Skincare:
- Serums & Creams: Incorporated into anti-aging, soothing, or antioxidant skincare products for their cellular protective benefits.
4. Pharmaceutical Research: As a standardized raw material for further development of herbal medicines.
Frequently Asked Questions (FAQ)
Q: What is the difference between Gypenosides and Ginsenosides?
A: Both are triterpenoid saponins with overlapping structures and benefits. Ginsenosides are primarily from the Panax (ginseng) genus. Gypenosides are from Gynostemma pentaphyllum and include a wider array of saponin structures, some identical to ginsenosides (e.g., Rb1, Rg3). Gypenosides are often noted for their particularly strong AMPK-activating effects related to metabolic health.
Q: Are there any known side effects or interactions?
A: Gypenosides are generally well-tolerated. Reported side effects are rare and mild, potentially including digestive upset. Due to its potential effects on blood sugar and blood pressure, individuals on related medications (hypoglycemics, antihypertensives) should consult a healthcare professional. It may have additive effects with other hypoglycemic or sedative agents.
Q: How do I choose between 50% and 98% purity?
A: The choice depends on your formulation goals and budget:
- High Purity (90%-98%): Ideal for high-potency supplements where capsule size is limited, or for advanced clinical research requiring a defined active profile. Cost is higher.
- Medium Purity (40%-80%): The most common choice for general supplement, food, and beverage applications. Offers excellent bioactive benefits and cost-effectiveness.
- Lower Ratio (10%-30%): Suitable for bulk ingredient blending or products where a lower concentration of actives is required alongside other botanical constituents.
Q: What is Gypenoside A, and is it a key marker?
A: Gypenoside A is one of the earliest identified and characteristic saponins in Gynostemma. While total gypenosides is the standard specification, some premium extracts may also standardize for specific gypenosides like Gypenoside A, Gypenoside XLIX, or the ginsenoside-equivalent Rg3 for targeted applications. Please inquire about specific marker compound options.
Process flow
High-quality raw materials ➩ washing and cleaning to remove impurities ➩ drying in the sun ➩ crushing raw materials ➩ extracting main components ➩ concentration ➩ extract ➩ spray drying ➩ testing ➩ finished product ➩ packaging ➩ sales and delivery
Packaging and shipping
The packaging adopts aluminum foil bags or cardboard drums and other methods. We adopt reasonable packaging schemes according to the actual situation of customers.
Minimum order quantity: 1kg, can be labeled as required
Mode of transportation: sea, air, express, etc.
Cooperative logistics provider: DHL/TNT/FEDEX/EMS/UPS, etc.
About products and prices
Each batch of the company's raw materials undergoes multi-process processing and quality inspection; quality inspection reports can be sent, and third-party inspections are supported. Many products are subject to bargaining. The larger the purchased quantity, the cheaper the price. Welcome to consult
About us
The company focuses on the production and sales of pharmaceutical intermediates, cosmetic raw materials, food additives, extracts, and other products. It has production equipment for the extraction, separation, synthesis, and fermentation of plant extracts and a strict quality control system. It has close cooperative relations with research institutions, more than ten years of export experience, and customers all over the world.
Contact us
We have a large number of high-quality sources and low factory-direct sales prices. We are also actively looking for high-quality buyers for long-term cooperation. If you are interested in our products, please contact us by email: ella.zhang@huilinbio-tech.com
Why choose us?
- Our Natural Ingredients are all-natural and free from harmful chemicals.
- We know that culture is the positive magnetic field of our business, another expression of our employees' ideals and beliefs and spirituality.
- As a supplier and manufacturer, we pride ourselves on providing excellent service and products.
- We strengthen the consciousness of fine products, carry forward the spirit of craftsmanship, and strive to create high-quality benchmark Gypenosides Powder.
- We are committed to providing our clients with the best possible Natural Ingredients at all times.
- We actively broaden the use of social talent channels and play the role of the main channel of existing talents.
- Our team is skilled and knowledgeable in all aspects of Natural Ingredients manufacturing.
- We treat our customers well, support our customers, and seek mutual benefits in strategic cooperation with our customers.
- We work closely with our clients to ensure that their needs are met and exceeded.
- We carry out the spirit of quality control issued by the company: responsible for the enterprise, responsible for the customers and responsible for the brand.
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