5-HTP (5-Hydroxytryptophan) 98% | Advanced Serotonin Precursor with Enhanced Bioavailability for Mood & Sleep Formulations
Product Overview: Precision Neuroscience Ingredient
Our pharmaceutical-grade 5-HTP (5-Hydroxytryptophan) represents the optimal choice for serotonin support formulations. With guaranteed ≥98% purity and advanced delivery system compatibility, this ingredient provides formulators with a scientifically-validated solution for mood, sleep, and neurological health applications.
Product Specification
| Parameter | Specification |
|---|---|
| Product Name | 5-HTP (5-Hydroxytryptophan) |
| CAS Number | 4350-09-8 |
| Purity (HPLC) | ≥98% |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C11H12N2O3 |
| Molecular Weight | 220.23 g/mol |
| Mesh Size | 100% through 80 mesh |
| Loss on Drying | ≤0.5% |
| Heavy Metals | ≤10 ppm |
| Residual Solvents | Meets ICH guidelines |
| Microbiological | Total Plate Count ≤1000 CFU/g |
| Storage | 2-8°C in airtight container, protect from light |
Key Health Benefits & Clinical Applications
1. Comprehensive Mood Support System
5-HTP's direct conversion to serotonin makes it particularly valuable for mood support formulations. Clinical research shows significant benefits for emotional well-being, with effects comparable to conventional antidepressants in some studies [1].
2. Sleep-Wake Cycle Regulation
Through the serotonin-melatonin pathway, 5-HTP supports healthy sleep architecture. Recent studies demonstrate improved sleep quality and reduced sleep latency, particularly in sustained-release formulations.
3. Fibromyalgia & Chronic Pain Support
Substantial clinical evidence supports 5-HTP's efficacy in fibromyalgia management. Research shows significant improvement in pain, morning stiffness, and anxiety symptoms [2].
4. Appetite Regulation & Metabolic Health
5-HTP promotes satiety through serotonin-mediated mechanisms, supporting healthy weight management when combined with lifestyle modifications.

Scientific Differentiation: 5-HTP vs. Tryptophan
Metabolic Pathway Advantage:
Tryptophan → (Rate-Limited Step) → 5-HTP → Serotonin → Melatonin
Unlike L-tryptophan, which competes with other amino acids for transport and faces a rate-limiting conversion step, 5-HTP offers distinct advantages:
- Direct Conversion: Bypasses the rate-limiting tryptophan hydroxylase step
- Superior Blood-Brain Barrier Penetration: Independent of competing amino acids
- Enhanced Efficacy: Demonstrated superior bioavailability in clinical settings
Synergistic Formulation Approaches
- Sleep Support: 5-HTP + GABA + Magnesium Glycinate + Vitamin B6
- Mood Enhancement: 5-HTP + SAMe + Rhodiola Rosea + Methyl B12
- Weight Management: 5-HTP + Green Tea Extract + Chromium
- Neurological Support: 5-HTP + Acetyl-L-Carnitine + CoQ10
Related product introduction
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23076-35-9 |
5-htp |
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|
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2-Bromo-4-methylpropiophenone |
145-82-7 |
Certificate of Analysis
|
Item |
Standard |
Test Result |
|
Assay(5-Hydroxytryptophan) |
≥98.0%(HPLC) |
99.20% |
|
Organoleptic |
||
|
Appearance |
Fine Powder |
Conforms |
|
Color |
Off White |
Conforms |
|
Odor |
Characteristic |
Conforms |
|
Taste |
Characteristic |
Conforms |
|
Physical Characteristics |
||
|
Moisture Content |
≤5.0% |
0.46% |
|
Heavy metals |
||
|
Total Heavy Metals |
≤10.0ppm |
Conforms |
|
Lead(Pb) |
≤3.0ppm |
Conforms |
|
Arsenic(As) |
≤2.0ppm |
Conforms |
|
Mercury(Hg) |
≤0.1ppm |
Conforms |
|
Cadmium(Cd) |
≤1.0ppm |
Conforms |
|
Microbiological Tests |
||
|
Total plate Count |
≤10000cfu/g |
180cfu/g |
|
Yeast & Mold |
≤100cfu/g |
Conforms |
|
E.Coli. |
≤30cfu/g |
Conforms |
|
Salmonella |
Negative in 25 g |
Not Detected |
|
Staphylococcus Aureus |
Negative in 25 g |
Not Detected |
|
Conclusion |
Conforms to the In house standard. |
Customized Service

Product packaging introduction
|
Quantity |
Packaging |
|
1-3kg |
1-3kg/aluminum foil bag with food-grade plastic bag inside. |
|
4-25kg |
4-25kg/carton with double food-grade plastic bag inside. |
|
≥25kg |
25kg/drum or carton with double food-grade plastic bag inside. |
|
Delivery time |
Usually within 3-5 working days after receiving the payment. |

Shipping & Delivery
|
Express(DHL/TNT/FEDEX) |
By Air |
By Sea |
|
1-50kg |
50-500kgs |
Above 500kgs |
|
Fast and convenient |
Fast and cheap |
Cheap and long time |
|
4-8 days |
4-8 days |
15-45 days |
|
Door to door |
To airport |
To port |

FAQ
What is the main market for your company's business?
We are determined to provide high-quality products to the world.
Is your delivery date fast?
We cooperate with many logistics companies and have a complete supply chain system. Shipments can be made within 3-5 days.
How do you make packaging products?
We use aluminum foil bags, cartons, barrels, and other methods to ensure that customers receive products safely.
How do you collect money?
We provide Western Union and L/C, T/T, Trade Assurance, and other methods, or negotiate according to customer requirements.
Do you have samples to send?
We are willing to provide customers with free samples for quality testing, you only need to bear the freight.
How to contact us?
Our company is a professional supplier of semi-finished materials, including plant extracts, fruit and vegetable powder, cosmetics, tablet candy, and other products; Our products are directly supplied from the manufacturer, so the price is very favorable, and the quality is guaranteed so that you can buy with confidence.
Now our company is hot-selling high-quality 5-htp powder, if you are interested in this product and want to know about it, you can consult our account manager through the international website or email. Our email address is ella.zhang@huilinbio-tech.com.
References
[1] Shaw, K. A., Turner, J., & Del Mar, C. (2002). Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database of Systematic Reviews, (1), CD003198. https://pubmed.ncbi.nlm.nih.gov/11869656/
[2] Caruso, I., Sarzi Puttini, P., Cazzola, M., & Azzolini, V. (1990). Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. The Journal of International Medical Research, 18(3), 201–209. https://journals.sagepub.com/doi/10.1177/030006059001800304
[3] Turner, E. H., et al. (2006). Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacology & Therapeutics, 109(3), 325-338. https://pubmed.ncbi.nlm.nih.gov/16023217/
Regulatory Compliance & Safety Notice:
This product is intended for use as a dietary ingredient by qualified manufacturers. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Important Contraindications: Do not use with SSRIs, MAOIs, or other serotonergic drugs. Not recommended during pregnancy or lactation. Always consult with a healthcare professional before use. Manufacturers must include appropriate warning labels and usage instructions.
Why choose us?
- We provide a wide range of products to meet the diverse needs of our customers.
- We are uniquely positioned to push the envelope and improve automation to move the world forward.
- Our processes are designed to ensure that our Herbal Extracts are produced in a safe and hygienic environment.
- Continue to strengthen lean management in the company's internal operations and continuously improve operational efficiency.
- Our factory is equipped with modern logistics systems to ensure speedy and accurate deliveries.
- In addition to the quality of our 5-HTP Powder, our excellent marketing team has also played a great role.
- Our Herbal Extracts are free of contaminants and meet the highest quality standards.
- We are open, frank and professional. We are responsible for the commitments and actions we make and abide by the highest ethical standards.
- Our team of experts ensures that all of our Herbal Extracts are of the highest quality.
- The growth of our company is inseparable from the trust, care and support from all walks of life, which are the greatest motivation for us to rise to the challenge and the confidence to achieve our business.
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