Introduction
Dipeptide Diaminobutyroyl Benzylamide Diacetate is a synthetic biomimetic peptide raw material widely used in high-end anti-aging skincare. It is artificially simulated according to the active structure of natural viper peptide, adopting safe synthetic technology, without neurotoxicity and irritation of real snake venom.
This ingredient features a mild muscle relaxation effect, helps improve expression lines and dynamic wrinkles, and is widely known in the cosmetic industry as a mainstream anti-wrinkle peptide raw material. It is popularly referred to in the market as a snake peptide raw material for its similar skincare mechanism.
Physicochemical Properties
| Parameter | Specification / Value | Notes / Significance |
|---|---|---|
| Appearance | White to off-white crystalline powder | - |
| Molecular Weight | 495.58 g/mol | - |
| Solubility | Soluble in water (up to 10 mg/mL). Soluble in DMSO. | Suitable for water-based serum, cream, and lotion formulation |
| Peptide Content | ≥ 80.0% | Core active specification |
| Acetate Content | 5.0% - 12.0% | Conforms to the salt form standard |
| Loss on Drying | ≤ 8.0% | Control moisture content |
| Storage Conditions | Long-term storage: -20°C; conventional storage: cool and dry place | Keep peptide activity stable |
Mechanism of Action
Dipeptide Diaminobutyroyl Benzylamide Diacetate wrinkle-reducing efficacy is rooted in its precise, targeted neuromodulatory action.
- Target: It acts as a reversible competitive antagonist at the muscle-type nicotinic acetylcholine receptor (nAChR) located on the postsynaptic membrane of the neuromuscular junction.
- Process: During a facial expression, a nerve signal releases acetylcholine (ACh). ACh must bind to the nAChR to trigger a muscle contraction. Dipeptide Diaminobutyroyl Benzylamide Diacetate competes with ACh for binding to the ε-subunit of this receptor.
- Result: When the snake peptide analog occupies the receptor, it blocks the binding of ACh. This prevents the receptor from activating, thereby inhibiting the sodium ion influx necessary for muscle fiber depolarization. The nerve signal is not transmitted, leading to a temporary and localized relaxation of the underlying facial muscles.
- Outcome: With reduced repetitive muscle contractions, the formation and depth of dynamic wrinkles (such as crow's feet, forehead lines, and frown lines) are visibly softened. This mechanism is non-invasive, topical, and designed to be fully reversible.
Key Benefits & Efficacy
- Clinically Studied Wrinkle Reduction: Designed to be up to 5 times more effective than other peptide-based neuro-inhibitors in relaxing muscles. A human clinical study reported a visible reduction of up to 52% in wrinkle depth after 28 days of daily use.
- Precision Targeting: Specifically acts on muscle receptors without affecting sensory nerves, providing a smooth, relaxed appearance without numbness or loss of sensation.
- Improves Skin Elasticity & Antioxidant Protection: Beyond muscle relaxation, it is noted to help promote collagen production for improved skin firmness and offers antioxidant properties to protect skin from environmental stressors.
- Excellent Safety & Compatibility: As a synthetic peptide, it is free from the toxins and allergens associated with actual snake venom. It is suitable for all skin types, including sensitive skin, and is gentle enough for the delicate eye area.
- Multi-Functional Cosmetic Agent: Research and patents also indicate its use in aluminum-free antiperspirant formulations, where it works by a similar mechanism to inhibit sweat gland activation.
Primary Applications in Cosmetics
Synthetic Snake Venom Tripeptide is a cornerstone ingredient in high-performance skincare, ideal for:
| Product Type | Target Area & Benefit | Recommended Use Level |
|---|---|---|
| Anti-Wrinkle & Anti-Aging Serums | Concentrated treatment for forehead, frown lines, and crow's feet. Delivers intensive muscle-relaxing and smoothing effects. | 2-5% |
| Moisturizers & Day/Night Creams | Provides all-over facial relaxation, prevents new wrinkle formation, and improves skin smoothness as part of daily care. | 1-3% |
| Eye Creams & Gels | Specifically targets fine lines around the eyes (crow's feet) and helps reduce puffiness caused by muscle tension. | 1-3% |
| Neck & Décolleté Creams | Addresses horizontal necklines and wrinkles on the chest caused by sleeping positions and movements. | 2-4% |
| Aluminum-Free Antiperspirants | Used as an active agent to reduce perspiration by blocking the neurotransmitter signal to sweat glands. | As per patent formulation. |
Formulation & Compatibility Guidelines
- Synergistic Combinations: For enhanced anti-aging results, combine with:
Hyaluronic Acid: To plump skin and fill wrinkles from within.
Vitamin C & Other Antioxidants: To boost protection against oxidative stress.
Other Signal Peptides (e.g., Palmitoyl Tripeptide-5): To stimulate collagen and provide structural support.
Neuro-inhibitory Peptides (e.g., Acetyl Hexapeptide-8): For a multi-target approach to muscle relaxation.
- Formulation pH: Stable in a broad pH range typical of skincare products (pH 4.0 - 7.0).
- Incorporation: Easily incorporated into the water phase of formulations. Add at temperatures below 45°C after the heating and cooling phase to preserve peptide integrity.
Frequently Asked Questions (FAQ)
Q: Is Snake Venom Tripeptide safe for pregnant or breastfeeding women?
A: While the ingredient is designed for topical use and has a good safety profile, there are no specific clinical studies on its use during pregnancy or lactation. As with any active cosmetic ingredient, it is recommended that pregnant or breastfeeding women consult with their healthcare provider before use.
Q: Are there any side effects?
A: Dipeptide Diaminobutyroyl Benzylamide Diacetate is generally well-tolerated. Due to its targeted mechanism, it does not cause systemic effects. As with any topical product, a patch test is recommended for individuals with very sensitive skin to rule out rare cases of individual sensitivity.
Q: What is the EWG rating for this ingredient?
A: The Environmental Working Group's (EWG) Skin Deep database rating can vary. Based on its safety profile as a synthetic peptide with a specific, localized action and absence of significant toxicity data, it typically receives a favorable (low hazard) rating. Formulators should check the latest EWG entry for the most current information.
Q: Can it be used in hair care products?
A: While its primary and proven application is in skincare for wrinkle reduction, the general skin conditioning properties of peptides mean it could theoretically be included in scalp or hair treatments aimed at improving skin health. However, specific efficacy data for hair benefits (like growth or strength) is not established or commonly cited.
Q: How does Snake Venom Peptide differ from Botox?
A: Botox (Botulinum Toxin) is a prescription neurotoxic protein that permanently blocks the release of acetylcholine itself, leading to prolonged muscle paralysis. Snake Venom Peptide is a cosmetic peptide that competitively and reversibly blocks the receptor. Its effects are milder, temporary (requiring daily application), and confined to the skin's surface without affecting nerve function.
Company Introduction
Xi'an Huilin Bio-tech Co., Ltd. is a leading provider of premium plant extracts for health applications. We supply herb extracts, standardized extracts, and fruit/vegetable powders. Dedicated to quality and innovation, we serve global customers in the supplements, food, and cosmetic industries, advancing human health. Click here to learn more.
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Incorporate the power of biomimetic science into your next generation of skincare products. Our high-purity Dipeptide Diaminobutyroyl Benzylamide Diacetate offers proven efficacy, reliable quality, and formulation flexibility.
Contact our technical sales team today to:
- Request a free sample and a detailed Certificate of Analysis (CoA).
- Get a competitive quote for your R&D, pilot, or bulk production needs.
Elevate your brand with the ingredient that delivers visible results. Let's create something remarkable together.
If you need this product, please get in touch with us at ella.zhang@huilinbio-tech.com.
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