Products Description
Laurocapram, commonly known as Azone, is a highly effective and widely utilized skin penetration enhancer in the pharmaceutical and cosmetic industries. Chemically known as 1-dodecylazacycloheptan-2-one with the molecular formula C₁₈H₃₅NO and molecular weight 281.48, it is a non-ionic surfactant that improves skin keratin permeability and promotes the penetration of both hydrophilic and lipophilic active ingredients.
As one of the most intensely studied absorption promoters, Azone was specifically designed as a skin penetration enhancer. It works primarily by fluidizing the intercellular lipids of the stratum corneum – the outermost layer of the skin. This reversible modulation of the skin barrier allows for enhanced delivery of a wide range of active ingredients without permanently damaging the skin structure.
Compared to traditional penetration enhancers like dimethyl sulfoxide (DMSO), Azone is non-irritating to the skin and exhibits a penetration effect 13 times stronger. At typical use concentrations (0.1% – 5%), it is generally considered non-irritating and has good stability with no significant side effects.
Our Laurocapram is manufactured through advanced synthesis processes with rigorous quality control, ensuring consistent purity (≥95%–98%), batch-to-batch consistency, and excellent performance. Available in both oil-soluble (standard) and water-soluble (emulsified) grades, our product meets the stringent quality requirements of cosmetic, pharmaceutical, and personal care manufacturers worldwide.
Key Features & Advantages
- Superior Penetration Enhancement – Penetration effect is 13 times stronger than DMSO, with significantly lower skin irritation
- Broad-Spectrum Compatibility – Accelerates penetration of both hydrophilic and lipophilic active ingredients, including vitamins (A, D, E), antibiotics, hormones, herbal extracts, and more
- High Purity – Available in ≥95% and ≥98% purity (GC) with full analytical documentation
- Excellent Formulation Compatibility – Compatible with anionic, cationic, and non-ionic surfactants; good stability across a wide pH range (2.5 – 7.0)
- Low Irritation Profile – Generally non-irritating at typical use concentrations (0.1% – 5%); no significant side effects
- Versatile Grades – Available as oil-soluble standard grade and water-soluble emulsified grade to suit different formulation needs
- Regulatory Compliant – Listed in China's Inventory of Used Cosmetic Ingredients (2021 Edition) as Item No. 08351
- Proven Track Record – One of the most extensively studied and documented penetration enhancers in cosmetic and pharmaceutical literature
Technical Specifications (Typical)
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Laurocapram (Azone) | - |
| CAS Number | 59227-89-3 | - |
| INCI Name | Laurocapram | - |
| Molecular Formula | C₁₈H₃₅NO | - |
| Molecular Weight | 281.48 g/mol | - |
| Appearance | Colorless to light yellow transparent viscous oily liquid | Visual |
| Assay (Purity) | ≥95.0% – ≥98.0% (GC) | GC |
| Melting Point | –7°C | - |
| Boiling Point | 160°C (at 50 mmHg) / 159–161°C (at 0.6 mmHg) | - |
| Density (20°C) | 0.906 – 0.926 g/cm³ | - |
| Refractive Index (25°C) | 1.470 – 1.473 | - |
| pH | Neutral | - |
| Heavy Metals | ≤0.001% | ICP-MS |
| Bromides | ≤0.1% | - |
| Solubility | Soluble in anhydrous ethanol, ethyl acetate, ether, benzene, cyclohexane; insoluble in water | - |
| Storage Condition | Sealed in dry, room temperature | - |
| Stability pH Range | 2.5 – 7.0 | - |
| Temperature Tolerance | Avoid temperatures above 60°C | - |
Specifications are for reference. Please request the current COA for batch-specific data.
Mechanism of Action – How It Works
Laurocapram enhances skin penetration through a sophisticated, multi-mechanism approach:
1. Lipid Bilayer Disruption & Fluidization
Azone disrupts the lipid bilayers and increases the fluidity and permeation in the lipid regions of the skin. Its dodecyl group inserts into the intercellular lipidic bilayer, increasing the motion of the alkyl chains of lipids and fluidizing the hydrophobic regions of the lamellate structure.
2. Increased Stratum Corneum Water Content
Azone markedly increases water content in the stratum corneum, as measured by skin conductance. This effect enhances both the lipid-rich and water-rich penetration pathways.
3. Reversible Barrier Modulation
The penetration-enhancing effect is reversible – Azone temporarily modulates the barrier function of the stratum corneum without causing permanent damage, making it safe for repeated use in cosmetic and pharmaceutical applications.
4. Keratin Softening
As a non-ionic surfactant, Azone improves skin keratin, promotes keratin softening, and enhances its permeability.
5. Dual Hydrophilic & Lipophilic Enhancement
Azone accelerates the penetration of both hydrophilic and lipophilic active ingredients through the skin, greatly reducing the retention time of active substances in the stratum corneum.
Key Benefits
Enhances Efficacy of Functional Cosmetics
- Azone is widely used in nutritional, therapeutic, and functional cosmetics to significantly improve product efficacy
- Ideal for brightening/whitening creams, scar removal products, sunscreens, slimming creams, firming creams, and hair growth tonics
- Helps active ingredients penetrate deeper into the skin for maximum benefit
Improves Transdermal Drug Delivery
- Accelerates penetration of a wide range of pharmaceutical actives including 5-fluorouracil, corticosteroids, antibiotics, and various herbal extracts
- Used in topical formulations such as sprays, aerosols, lotions, liniments, emulsions, creams, ointments, suppositories, film-forming agents, and patches
- Recommended use concentration: 0.1% – 1% in pharmaceuticals; commonly 0.5% – 5%
Enhances Hair Care & Color Products
- Promotes penetration of nutrients and colorants in hair tonics and hair dyes
- Improves efficacy of scalp treatments and hair growth products
Versatile Industrial Applications
- Used as a penetration enhancer in agrochemicals to improve efficacy of pesticides and plant growth regulators
- Applied in leather and textile dyeing to enhance color penetration
Superior to Traditional Enhancers
- 13 times more effective than DMSO as a penetration enhancer
- Non-irritating to skin at typical concentrations, unlike DMSO
- Effective at very low concentrations (0.5% – 2%)
Excellent Stability & Safety Profile
- Exhibits good stability in formulations
- No significant side effects or skin stimulation at recommended use levels
- Well-tolerated; compatible with most cosmetic ingredients
Applications
- Functional Cosmetics – Brightening/whitening creams, anti-spot treatments, scar removal products, sunscreens, slimming/firming creams, anti-aging formulations, and other efficacy-driven skincare
- Topical Pharmaceuticals – Ointments, creams, gels, sprays, aerosols, lotions, liniments, suppositories, patches, and transdermal drug delivery systems
- Hair Care – Hair tonics, hair growth serums, hair dyes, and scalp treatment products
- Personal Care – Advanced skincare, sensitive skin care, whitening products, depilatories, and color cosmetics
- Agrochemicals – Penetration adjuvants for pesticides, fungicides, and plant growth regulators
- Industrial – Leather dyeing, textile printing, and coloring auxiliaries
Frequently Asked Questions (FAQ)
Q: What is the physical form of Laurocapram?
A: Laurocapram is a colorless to light yellow transparent viscous oily liquid at room temperature. It has a melting point of –7°C. If thickening occurs due to low temperature, warm and shake well before use – product quality remains unaffected.
Q: How does Laurocapram compare to DMSO?
A: Azone is 13 times more effective as a penetration enhancer than DMSO and is non-irritating to the skin at typical use concentrations, whereas DMSO can cause skin irritation.
Q: What are the recommended use concentrations?
A:
- Cosmetics: 0.5% – 6% depending on product type
- Pharmaceuticals: 0.1% – 1%; commonly 0.5% – 5%
- Maximum safe use level (China): 3% for whole body leave-on products; 3% for eye area leave-on products
Q: Is Laurocapram safe for use in cosmetics?
A: Yes. Laurocapram is listed in China's Inventory of Used Cosmetic Ingredients (2021 Edition) and is not a prohibited substance. At typical use concentrations (0.1% – 5%), it is generally considered non-irritating. The safe use level is 3% for leave-on products.
Q: What is the solubility of Laurocapram?
A: Laurocapram is soluble in anhydrous ethanol, ethyl acetate, ether, benzene, and cyclohexane. It is insoluble in water. Water-soluble emulsified grades are available upon request.
Q: Is Laurocapram suitable for all skin types?
A: Yes. At recommended use levels, Laurocapram is well-tolerated and suitable for various skin types. Its low irritation profile makes it appropriate for sensitive skin applications.
Q: What types of products benefit from Laurocapram?
A: Laurocapram is widely used in brightening creams, anti-spot treatments, scar removal products, sunscreens, slimming/firming creams, hair tonics, hair dyes, topical pharmaceuticals, and transdermal drug delivery systems. It enhances the penetration of vitamins, antibiotics, hormones, herbal extracts, and other active ingredients.
Our Certification
How To Contact Us?
For bulk inquiries, samples, or custom specifications, please contact our sales team. We look forward to partnering with you for high‑quality Laurocapram (Azone) that meets your exact requirements.
Email:
Why choose us?
- We guarantee you will be delighted with our products and services.
- After years of operation, our company has established a perfect product system. Through the combination of traditional channels and Internet channels, a complete marketing context has been formed.
- We strive to ensure our customers always receive top-quality products and services.
- We value the development of each employee and have built a diverse corporate culture that is committed to the mutual growth of the company and its employees.
- Our knowledgeable staff is always available to answer any questions you may have.
- With high quality products, competitive price and all-round service, the company has won our reputation and reputation.
- Our commitment to transparency sets us apart from our competitors.
- Our company adheres to the enterprise spirit of "unity, practical work, high efficiency, enterprising" and the quality concept of "quality determines everything, quality leads the future".
- We are committed to providing our customers with the highest level of service possible.
- Good Laurocapram Azone Powder come from high-quality material selection and excellent technical strength.
Hot Tags: Laurocapram Azone Liquid, China, suppliers, manufacturers, factory, wholesale, buy, price, bulk, pure, natural, high quality, in stock, for sale, Hexamidine Diisethionate Powder, Cosmetic Raw Material, Betaine Powder, Marine Fish Collagen Powder, Natural Astaxanthin Powder, Hyaluronic Acid Powder
