Hydroxypinacolone Retinoate (HPR) – Next-Gen Gentle Retinoid for Sensitive Skin
Brief Introduction
Hydroxypinacolone Retinoate (HPR) is a synthetic, next-generation retinoid ester widely recognized for its stability and skin tolerance. Chemically, it is formed by esterifying all-trans retinoic acid (the active form of Vitamin A) with hydroxypinacolone. This unique esterification enhances its properties significantly compared to traditional retinoids like retinol or retinoic acid.
Product Specifications
| Property | Specification |
|---|---|
| Product Name | Hydroxypinacolone Retinoate (HPR) |
| Molecular Formula | C₂₀H₂₈O₃ |
| Molecular Weight | 316.44 g/mol |
| CAS No. | 893412-73-2 |
| Purity | 99% (HPLC) |
| Melting Point | 98-102°C |
| Solubility | Oil-soluble (ethanol, squalane) |
| Shelf Life | 24 months (under inert gas) |
| Packaging | 100g amber glass bottles / 1kg foil bags |
| Storage | -20°C, protected from light & oxygen |
Key Benefits & Clinical Validation
✅ Supports normal skin condition
- Clinically tested for low irritation potential
Activates retinoic acid receptors without conversion – no redness/peeling1.
- Supports skin firmness
- Helps protect against environmental stress
- Stability Champion
Application Guidelines
| Product Type | Synergistic Combinations |
|---|---|
| Mature Skin Serums | Niacinamide + Hyaluronic Acid |
| Sensitive Skin | Ceramides + Oat Beta-Glucan |
| Body Lotions | Bakuchiol (1:1 ratio)2 |
Technical Advantages vs. Traditional Retinoids
| Parameter | HPR | Retinol |
|---|---|---|
| Irritation | None (clinical RIPT)3 | High (↑TEWL, peeling) |
| Stability | Photostable (daytime safe) | Degrades in 30 min light |
| Efficacy Speed |
Visible in 2 weeks |
Requires 8-12 weeks |
| pH Compatibility | 3.0-7.0 | Unstable below pH 5.0 |
FAQ
Q: Solubility in silicone-based serums?
A: Pre-dissolve in ethanol (1:2 ratio) before adding to cyclomethicone.
Q: Pregnancy-safe formulation?
A: Not evaluated – retinoid analogs contraindicated. Use bakuchiol instead.
Q: MOQ for stabilized formulations?
A: 1kg MOQ (powder). Pre-solubilized oils (5% HPR in squalane): 5kg MOQ.
Company Introduction
Xi'an Huilin Bio-tech Co., Ltd. is a leading provider of premium plant extracts for health applications. We supply herb extracts, standardized extracts, and fruit/vegetable powders. Dedicated to quality and innovation, we serve global customers in the pharmaceutical, food, and cosmetic industries, advancing human health. Click here to learn more.
OME service
Packaging & Shipping
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How To Contact Us?
If you need this product, please get in touch with us at ella.zhang@huilinbio-tech.com.
References
- Dermatol Ther. 2020; 33(6): e14068. [Receptor activation]
- Exp Dermatol. 2023; 32(4): 478-487. [UV repair]
- Clin Cosmet Investig Dermatol. 2021; 14: 1201–1210. [Bakuchiol synergy]
- Contact Dermatitis. 2021; 85(3): 291-299. [Safety profile]
*This is a cosmetic ingredient. Not intended for medical use.
Statements have not been evaluated by the FDA.
"Anti-aging" refers to temporary cosmetic improvements only.
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