Product Introduction
Acetyl Hexapeptide-8 is a synthetic anti-aging cosmetic peptide widely applied in high-end skincare formulations. This high-efficiency active ingredient is well-known for improving the appearance of facial fine lines and wrinkles, especially on the forehead and eye contour areas. It works by relieving facial muscle tension, serving as a mild and non-invasive skincare ingredient for daily anti-wrinkle and anti-aging care.
High-purity Acetyl Hexapeptide-8 powder is widely used as the core raw material for developing anti-wrinkle serums, firming creams, and lotions worldwide.

Biophysical & Chemical Parameters Table
| Parameter | Specification |
|---|---|
| Product Name | Acetyl Hexapeptide-8 Powder |
| INCI Name | Acetyl Hexapeptide-8 |
| CAS Number | 616204-22-9 |
| Molecular Formula | C₃₄H₆₀N₁₄O₁₂S |
| Molecular Weight | 888.992 g/mol |
| Purity | ≥ 98% |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water |
Mechanism of Action
The anti-wrinkle effect of Acetyl Hexapeptide-8 comes from its targeted neuroregulation activity. It acts as a competitive inhibitor targeting the SNARE complex, which plays a key role in neurotransmitter release from nerve endings.
When applied topically, the ingredient simulates the protein structure related to nerve signal transmission, interferes with the normal formation of the SNARE complex, and moderately reduces the release of neurotransmitters. It relieves facial micro-muscle contraction, smooths dynamic expression lines, and prevents the formation of new fine lines caused by repeated facial movements.

Key Benefits of Acetyl Hexapeptide-8 Powder

- Reduce wrinkle depth and improve existing fine lines around the eyes and forehead
- Relieve facial muscle tension and prevent new expression lines
- Improve skin smoothness, firmness, and overall elasticity
- Mild formula, good compatibility, suitable for long-term topical cosmetic use
- Fast-acting effect, visible skin improvement with continuous use
- Can be compounded with hyaluronic acid, matrixyl, and other actives for a synergistic anti-aging effect
Applications in Cosmetic Formulations
Suitable for various cosmetic and personal care products, easy to dissolve in the water phase, and compatible with most skincare formulations.
Recommended Usage Level: 2% - 10% in the final finished formula.
Ideal for:
- Anti-Aging & Anti-Wrinkle Serums
- Daily Moisturizing & Firming Creams
- Eye Contour Gels and Eye Creams
- Neck Firming and Lifting Skincare Products

Frequently Asked Questions (FAQ)
Q: Is Acetyl Hexapeptide-8 safe to use?
A: Yes. When used in recommended concentrations in topical cosmetic products, Acetyl Hexapeptide-8 is considered very safe. It is compliant with global cosmetic regulations, including those in the EU, USA, and China. It is not a toxin and does not paralyze muscles like injectable neurotoxins.
Q: How long does it take to see results?
A: Visible improvements in skin smoothness and a reduction in wrinkle depth can typically be observed after 4 weeks of consistent, twice-daily application. Optimal results are usually achieved after 12-16 weeks of continuous use.
Q: Can Acetyl Hexapeptide-8 be used with other active ingredients like Vitamin C or Retinol?
A: Absolutely. Acetyl Hexapeptide-8 features high compatibility with most cosmetic actives. It is often formulated with Hyaluronic Acid for hydration, Antioxidants like Vitamin C for skin protection, and other functional peptides to deliver multi-mechanism anti-aging benefits.
Q: What is the difference between Acetyl Hexapeptide-8 and injectable Botox?
A: Both help improve expression wrinkles, but they work in completely different ways.
Injectable Botox is a purified neurotoxin that fully blocks nerve signals. Acetyl Hexapeptide-8 is a cosmetic topical peptide that gently modulates neurotransmitter release. It offers a mild, non-invasive cosmetic alternative for daily skincare use.
Q: How should I store the powder?
A: To maintain stability and efficacy, store Acetyl Hexapeptide-8 powder in a cool, dry place, protected from light and moisture. Refrigeration is recommended for long-term storage.
Contact Us
Ready to create cutting-edge, high-performance anti-aging skincare products? Acetyl Hexapeptide-8 Powder is your ideal core raw material for a stable and effective anti-wrinkle formulation.
Contact us today to request a sample, get a quote, or access a comprehensive technical data sheet. Elevate your cosmetic formulations with high-purity cosmetic peptide raw materials.
E-mail: ella.zhang@huilinbio-tech.com.
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Why choose us?
- Our Cosmetic Raw Materials are created using top-of-the-line machinery and equipment.
- Relying on high-quality products and perfect after-sales service system, the company has repeatedly achieved good results in China, while attracting the attention of many manufacturers and forming a number of strategic alliances.
- Trust us to provide you with the best Cosmetic Raw Materials in the market.
- We practice a balanced and sustainable business philosophy with a corporate image of high ambition and down-to-earth.
- Our team of experts is dedicated to meeting the needs of our customers.
- As a participant in China’s high-end products, we continue to spur ourselves and seek breakthroughs to develop high-quality products with innovative technological competitiveness, so as to help more manufacturing companies improve the level of quality control, and provide production, R&D and quality for various industries. Management creates greater value.
- Our focus on quality and service is what sets us apart.
- We promote our own development and growth, and seek benefits for our employees; actively give back to the society and make contributions to the society.
- Our knowledgeable staff is always available to answer any questions you may have.
- Constant pursuit of high-tech and high quality is our goal; new development and promotion of the Acetyl Hexapeptide-8 Powder is our responsibility.
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