Product introduction：
Betulinic acid powder is a natural lupane pentacyclic triterpene compound. The chemical name is 3β-hydroxyl-lup-20 (29)-ene-28-OIC acid, molecular formula C30H48O3, molecular weight 456.71, CAS number 472-15-1, boiling point 550.0±33.0 °C(Predicted), and acidity coefficient (PKA) 4.61. Betulinic acid powder is extracted from the bark of birch. It is a natural luminescent pentacyclic triterpenoid compound. It has many biological characteristics. It has the functions of anti-inflammation, anti-bacteria, anti-virus and anti-aging, and is a high-efficiency, low-toxicity and few side effects.
Source and acquisition method：
Natural betulinic acid is mainly extracted from the bark of Betula platyphylla, and also exists in many plants, including Peach Tree, Ziziphus Spinosae Seed, Jujube, Platanus acerifolia, Zizyphus spinosa, Prunella vulgaris and so on.
There are mainly methods such as plant extraction, chemical synthesis and biotransformation.
1. Plant extraction method
Traditional extraction methods mainly use ethanol, ethyl acetate and methanol as extraction solvents, and adopt immersion method, Soxhlet extraction method, heating reflux extraction method and ultrasonic extraction method. In recent years, new methods such as supercritical fluid extraction, microwave-assisted extraction and solid-liquid extraction have also been developed. However, due to the low content of betulinic acid in plants, this method has the problems of large raw material consumption, many impurities and low yield.
2. Chemical synthesis method
One-step synthesis method
The extraction of betulin and the preparation of BA are carried out simultaneously. Plants are leached with organic solvents such as dichloromethane, chloroform, acetone, tetrahydrofuran and DMF to extract betulin with high content. At the same time, oxidants such as zinc nitrate and chromium nitrate are attached to solid carriers such as silica gel, alumina and jiaolingshi, and the extracted betulin is oxidized to obtain BA. This method is not selective, the conditions are difficult to control, the yield is low and the purification step is still needed.
Semi-synthesis method
Semi-synthetic method is to extract betulin from plants first, and then make BA from betulin through a series of chemical reactions. Because the content of betulin in plants is relatively high, it can be obtained by direct extraction and the cost is relatively low, so semi-synthesis method can effectively reduce the cost. Experiments show that betulin can be selectively oxidized to betulinic acid with a yield of 93-98% under the catalysis of Cr( VI) compound in acetone (15-25℃) solution with alumina as the carrier, and at the same time, the alumina carrier can adsorb and remove toxic compounds.
3. Biotransformation method
Structural modification of the substrate by microorganisms or enzymes produced during metabolism; Compared with chemical synthesis, biotransformation has the advantages of green pollution-free, mild conditions, more stereoselectivity and regional selectivity. It was found that the metabolic flow balance of fatty acid and terpenoid precursor synthesis pathway had a significant effect on BA synthesis, and the production of BA was significantly increased by co-expressing the key regulatory genes (HFA1, HMG1 and ERG 9) in these two metabolic pathways. The engineering strain could synthesize mg-level BA per liter of culture medium, and the preparation and synthesis of BA rose to a new height.
Characteristics of betulinic acid powder：
Natural ingredients: betulinic acid powder is extracted from birch bark, and contains no chemical additives or synthetic ingredients. It is a natural plant extract, which accords with modern people's pursuit of natural and green products.
Antibacterial inhibition: Betulinic acid powder has good antibacterial and inhibitory effects. It can effectively inhibit the growth of bacteria, fungi and other microorganisms and help to maintain a clean and hygienic environment.
Cleaning and decontamination ability: Betulinic acid powder has strong cleaning and decontamination ability, which can remove oil stains and other dirt. It can gently remove dirt during cleaning and protect the surface of the cleaned object at the same time.
Adsorption of odor: Betulinic acid powder has good adsorption capacity, which can help remove odor. It can adsorb odor molecules in the air and make the air fresh.
Environmental protection and health: As betulinic acid powder is a natural extract, it contains no harmful chemicals and is nontoxic and harmless to human body and environment. Using betulinic acid powder for cleaning and nursing can reduce the impact on the environment and better protect human health.
Multifunctional uses: Betulinic acid powder can be widely used in various fields, including household cleaning, personal care, beauty and so on. It can be used to clean kitchens, bathrooms, clothes, etc., and can also be used as a component of products such as masks and shower gels.
Can betulinic acid powder resist aging?
Betulinic acid powder can help anti-aging to some extent. Betulinic acid itself has antioxidant and anti-inflammatory properties, which help to slow down the aging process of skin. Antioxidant ability can help neutralize free radicals and reduce damage to skin, while anti-inflammatory properties can help reduce skin inflammation and sensitivity and promote skin health.
In addition, betulinic acid powder can be used as a natural plant extract in personal care products and beauty products. The use of betulinic acid powder in facial care products may bring some anti-aging effects, such as helping to reduce wrinkles and improve skin color uniformity.
Application of betulinic acid powder：
Household cleaning: Betulinic acid powder can be used to clean household items and surfaces, such as kitchen countertops, floors, glass and so on. You can mix a proper amount of betulinic acid powder with water to make a paste, then dip it with a cloth or sponge and gently wipe the area to be cleaned.
Personal care: Betulinic acid powder can be added to personal care products such as shower gel, shampoo and facial mask, which has the functions of cleaning, antibacterial and odor absorption. Appropriate amount of betulinic acid powder can be added to the product as needed, and then used according to the normal use method.
Beauty and skin care: betulinic acid powder can be used to make homemade mask or facial cleanser. Betulinic acid powder can be mixed with appropriate liquid (such as water, flower water or base oil) to make paste, then applied to the face, gently massaged and washed with warm water.
Slimming: Betulinic acid powder can also be used in slimming products. It has the ability of cleaning and decontamination, which can help purify the skin, promote blood circulation and improve the skin texture.
Function of betulinic acid powder：
Antibacterial and anti-inflammatory: Betulinic acid powder has antibacterial and anti-inflammatory properties, which can inhibit the growth of bacteria and fungi and reduce skin inflammation. This makes it an effective ingredient for treating skin problems such as acne and eczema.
Antioxidant: Betulinic acid powder has antioxidant effect, which can neutralize free radicals and reduce oxidative damage to skin. This helps to delay the skin aging process and reduce the appearance of fine lines and wrinkles.
Cleaning and adsorption: betulinic acid powder can adsorb excess oil and impurities, clean skin pores and reduce the formation of blackheads and acne. It can also adsorb odorous substances and keep the skin fresh.
Moisturizing and moisturizing: Betulinic acid powder has good moisturizing performance, which can increase the moisture content of skin and improve the softness and smoothness of skin. It can also form a protective film, reduce water loss and provide lasting moisturizing effect.
Even skin tone: Betulinic acid powder helps to even skin tone and reduce the appearance of spots and freckles. It can inhibit the production of melanin, brighten skin tone and make skin brighter and more uniform.
How to contact us?
Our company is a professional supplier of semi-finished materials, including plant extracts, fruit and vegetable powder, cosmetics, tablets and sweets. Our products are directly supplied by manufacturers, so the price is very favorable and the quality is guaranteed. You can buy with confidence. Now our company is selling high-quality Betulinic acid powder. If you are interested in this product and want to know about it, you can consult our account manager through the international website or email. Our e-mail address is ella.zhang@huilinbio-tech.com.