The High-Purity Active Compound from Rhodiola Rosea
Salidroside Powder (CAS 10338-51-9) is the definitive, high-purity active compound isolated from the adaptogenic herb Rhodiola rosea L. Known scientifically as *p*-hydroxyphenethyl-β-D-glucoside, it is the key glycoside responsible for many of Rhodiola's renowned benefits, including anti-fatigue, neuroprotective, and anti-stress effects. Our product is available in a range of purities from 3% to 98%, offering versatility for nutraceutical, cosmetic, and pharmaceutical formulations where consistent, measurable potency is critical.
Core Product Specifications
| Attribute | Specification |
|---|---|
| Product Name | Salidroside (Rhodioloside) |
| Botanical Source | Rhodiola rosea L. (Root & Rhizome) |
| Appearance | White to light brown powder (purity-dependent) |
| Available Purity | 3%, 5%, 10%, 50%, 98% (HPLC) |
| Molecular Formula | C₁₄H₂₀O₇ |
| Molecular Weight | 300.30 g/mol |
| Solubility | Very soluble in water, methanol, ethanol |
| Melting Point | 159 - 160°C |
| Analysis Method | HPLC-DAD / HPLC-ELSD |
| Storage | 2-8°C, sealed, protected from light |
| Shelf Life | 24 months |
Salidroside: Mechanism and Evidence-Based Benefits
Salidroside is a potent adaptogen, meaning it helps the body resist physical, chemical, and biological stressors. Its benefits are supported by a growing body of pre-clinical research.
- Neuroprotection & Cognitive Support: Salidroside exhibits significant neuroprotective properties. Research indicates it can reduce neurological deficits and cerebral infarct volumes in models of stroke, with a surprisingly wide therapeutic time window. It has also been shown to promote the differentiation of stem cells into neuron-like cells, suggesting potential for neural repair.
- Mood and Stress Resilience: As a key component of Rhodiola, salidroside contributes to the herb's traditional use in improving mental state and combating fatigue. It helps modulate the body's stress response systems. Notably, a full-spectrum Rhodiola extract was found to be more effective at dampening stress-induced corticosterone release than salidroside alone, highlighting a synergistic "entourage effect".
- Antioxidant & Anti-Aging Activity: Salidroside is a powerful antioxidant that helps neutralize free radicals and reduce oxidative damage at the cellular level. This activity underpins its benefits for cardiovascular health, anti-aging, and overall cellular protection.
- Energy Metabolism & Physical Performance: Traditionally used to enhance endurance, salidroside is believed to optimize cellular energy production, helping to reduce feelings of physical and mental fatigue.
Salidroside vs. Rosavin: Understanding Rhodiola Compounds
When formulating with Rhodiola, it's essential to distinguish between its active compounds.
- Salidroside: A phenylethanol derivative (tyrosol glucoside). It is consistently regarded as one of the primary active markers for Rhodiola quality and efficacy, particularly in cognitive and neuroprotective applications.
- Rosavin: A cinnamyl alcohol glycoside. Along with rosarin and rosin, it is part of the "rosavins" group, which are specific to the Rhodiola rosea species and often used as standardization markers.
For Formulators: While both are important, salidroside is often prioritized in research for its direct neuroprotective and anti-fatigue effects. A high-quality Rhodiola extract should standardize for both salidroside and rosavins, but purified salidroside powder allows for targeted, high-dose applications in specific formulations.
Applications in Key Industries
1. Nutraceuticals & Dietary Supplements
- Stress & Energy Formulas: The primary ingredient in capsules, tablets, and powders targeting mental performance, stress adaptation, and combatting fatigue.
- Cognitive Health Supplements: Used in blends designed to support memory, focus, and long-term brain health, leveraging its neuroprotective properties.
- General Wellness: Incorporated into daily supplements for its broad adaptogenic and antioxidant support.
2. Cosmetic & Skincare Products
- Anti-Aging & Protective Serums: Its potent antioxidant activity helps protect skin from environmental oxidative stress, slowing the appearance of aging.
- Soothing & Revitalizing Creams: Used for its anti-inflammatory properties to calm irritated skin and improve resilience.
3. Pharmaceutical & Clinical Research
- Reference Standard: High-purity (98%) salidroside is essential as a reference standard (CRS) for HPLC quality control of Rhodiola materials and finished products.
- Investigational New Drug Research: Used in preclinical research for neuroprotection, cardioprotection, and metabolic disorders due to its promising pharmacological profile.
Frequently Asked Questions (FAQ)
Q: What is the recommended salidroside dosage?
A: Dosage depends entirely on the final product type and desired benefit. In clinical studies on Rhodiola extracts, daily doses often provide between 100 mg to 400 mg of extract, standardized to contain 1-3% salidroside. For high-purity salidroside powder used as a standalone active, effective doses in research settings are typically much lower, but specific formulation advice should be sought from a clinical expert.
Q: Is salidroside the same as Rhodiola extract?
A: No. Salidroside is a single, isolated compound (typically 3-98% purity). Rhodiola extract is a complex mixture containing salidroside, rosavins, flavonoids, and other plant compounds. Full-spectrum extracts may offer synergistic benefits, while purified salidroside allows for precise, potent dosing of the specific active.
Q: Is your salidroside suitable for cosmetic (INCI) use?
A: Yes. Our high-purity salidroside powder is suitable for cosmetic applications. The INCI name is "Salidroside."
Q: How should I store this powder?
A: To ensure long-term stability and prevent degradation, salidroside powder must be stored in a sealed container at refrigerated temperatures (2-8°C or 4°C) and protected from light.
Q: Can you provide salidroside with a Certificate of Analysis (CoA)?
A: Yes. A detailed CoA from an independent laboratory, confirming identity (MS/NMR), purity (HPLC), and heavy metals/residual solvents, is provided with every batch.
Strict inspection
Each batch of raw materials undergoes multiple process quality inspections, and an inspection report can be issued. In order to ensure that the buyer receives the goods in good condition, all our employees carefully control every link.
Packaging and shipping
The sample is packaged in an aluminum foil bag and a double-layer PE ziplock bag, which is waterproof and moisture-proof to ensure that the product does not deteriorate
The bulk goods are packed in 25kg standard cardboard drums, which can be sub-packaged inside, which is convenient for customers to use
Transportation methods: sea, air, express (DHL/FEDEX/TNT/EMS/UPS), etc., which can meet the needs of customers in different regions
Technical advantages
At present, the commonly used methods of plant extracts used by our company include solvent extraction, ultrasonic extraction, microwave extraction, and enzyme extraction, while supercritical fluid extraction and microwave-assisted extraction are widely used as new extraction technologies.
After-sales service
We have a professional after-sales service team, from pre-sale consultation to complete receipt of the goods, the whole process has a dedicated reception, and consultation is available at any time. We help customers actively deal with problems and are willing to reach long-term cooperation.
Contact us
Ready to enhance your formulations with high-purity, research-backed Salidroside?
Contact us today to request a free sample, discuss custom purity specifications (from 3% to 98%), or obtain a comprehensive technical dossier for your product development needs.
The company's main products are plant and animal peptides, raw meal powder, cooked powder/fruit and vegetable powder, and various animal and plant extracts/monomers. Animal and vegetable peptides, food raw materials, health care products raw materials, high-content monomers, and other products can meet the needs of our customers. If you need to purchase, please contact us by email: ella.zhang@huilinbio-tech.com
Why choose us?
- Our Natural Ingredients are of the highest quality and are sure to meet your needs.
- In continuous communication with customers, we continue to optimize the humanized design, function and overall design of our Salidroside Powder.
- Each of our Natural Ingredients is backed by years of research and development.
- We constantly stimulate the enthusiasm, initiative and creativity of our employees, enhance the cohesion and centripetal force of the enterprise, and form the inexhaustible power of enterprise development.
- Our team is skilled and knowledgeable in all aspects of Natural Ingredients manufacturing.
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- Our prices for Natural Ingredients are unbeatable.
- We strive to create value for global users and partners, and do our best for the growth, honor and dream of our team.
- Our prices for Natural Ingredients represent excellent value for money.
- Its leading products are popular in the domestic and foreign markets with their outstanding quality and good reputation. They have achieved good sales performance over the years and are currently developing rapidly with vigorous momentum.
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