Xi'an Huilin Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of palmitoyl hexapeptide-12 powder in China. With abundant experience, we are committed to providing high quality natural products with competitive price. Please feel free to wholesale bulk pure palmitoyl hexapeptide-12 powder for sale here from our factory.
What is Palmitoyl Hexapeptide-12?
Palmitoyl Hexapeptide-12 (CAS: 171263-26-6) is a synthetic biomimetic lipopeptide composed of six amino acids with the sequence Pal-Val-Gly-Val-Ala-Pro-Gly (Pal-VGVAPG). It is the palmitoylated (lipidated) form of the elastin-derived VGVAPG hexapeptide - a fragment of the elastin protein that occurs naturally in the skin.
The palmitoyl chain (a fatty acid anchor) greatly improves compatibility with lipid-rich, anhydrous and oil-in-water formulations, which is why this peptide is a popular choice for oil-based anti-aging concepts. While the non-lipidated VGVAPG sequence is primarily used in research settings, the palmitoylated version is designed specifically for cosmetic formulation compatibility.
Palmitoyl Hexapeptide-12 belongs to the matrikine-type signal peptides - small peptides derived from extracellular matrix proteins that are widely used in anti-aging cosmetics. It is a well-established ingredient in firming and elasticity-positioned formulas, helping skin look smoother, suppler and more resilient.
Our Palmitoyl Hexapeptide-12 Powder is manufactured through advanced Solid-Phase Peptide Synthesis (SPPS) with palmitoylation, followed by rigorous HPLC purification, ensuring exceptional purity (≥98%), consistent batch-to-batch quality and reliable performance in formulation.
Key Features & Advantages
- Elastin-Derived Signal Peptide – Based on the VGVAPG sequence derived from elastin; a well-established choice for firming and elasticity-positioned formulas.
- Oil-Compatible – The palmitoyl (lipid) chain provides excellent compatibility with oil-based, anhydrous and oil-in-water systems.
- High Purity – Available in ≥98% and ≥95% purity (HPLC+MS) with full analytical documentation.
- Matrikine-Type Signal Peptide – Belongs to the family of ECM-derived signal peptides widely used in premium anti-aging concepts.
- Multi-Benefit Anti-Aging Support – Designed for formulations targeting loss of firmness, loss of elasticity and the appearance of fine lines.
- Excellent Solubility – Soluble in water, glycols, oils and DMSO; easy to incorporate across a wide range of textures.
- Broad pH Stability – Stable at pH 4.0 – 7.5.
- Synthetic & Animal-Free – 100% synthetic production via SPPS; vegan and cruelty-free.
- Regulatory Documentation – Listed in China's Inventory of Used Cosmetic Ingredients (IECIC); supplied with a complete technical file (COA, MSDS, specification sheet) for your compliance review. Intended for cosmetic use only.
- Versatile Formats – Available as lyophilized powder or liquid solution.
Technical Specifications (Typical – ≥98% Grade)
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Palmitoyl Hexapeptide-12 | – |
| CAS Number | 171263-26-6 | – |
| INCI Name | Palmitoyl Hexapeptide-12 | – |
| Molecular Formula | C₃₈H₆₈N₆O₈ | – |
| Molecular Weight | 736.98 – 737.0 g/mol | – |
| Amino Acid Sequence | Pal-Val-Gly-Val-Ala-Pro-Gly (Pal-VGVAPG) | – |
| Appearance | White to off-white lyophilized powder | Visual |
| Assay (Purity) | ≥98.0% (HPLC) | HPLC |
| Purity (≥95% grade) | ≥95.0% (HPLC+MS) | HPLC + MS |
| Counter-Ion | TFA Salts (Acetate/HCl exchange available) | – |
| Solubility | Soluble in water, glycols, oils, DMSO | – |
| pH Stability Range | 4.0 – 7.5 | – |
| Loss on Drying | ≤5.0% | 105°C |
| Heavy Metals (as Pb) | ≤10 ppm | ICP-MS |
| Lead (Pb) | ≤2 ppm | ICP-MS |
| Arsenic (As) | ≤2 ppm | ICP-MS |
| Total Plate Count | ≤100 CFU/g | USP <61> |
| Yeast & Mold | ≤10 CFU/g | USP <2021> |
| E. coli | Negative | USP <2022> |
| Salmonella | Negative | USP <2022> |
Specifications are for reference. Please request the current COA for batch-specific data.
Key Skin Benefits
Palmitoyl Hexapeptide-12 is a well-established cosmetic peptide used in firming and elasticity-positioned skincare. Here are the key highlights:
1. Supports the Appearance of Firmer, More Resilient Skin
- The VGVAPG sequence is derived from elastin - the protein associated with skin's ability to "snap back".
- Widely used in formulas designed to support the look of firmness and resilience.
- A popular ingredient for products positioned around loss of firmness.
2. Helps Support Skin Smoothness & the Look of Fine Lines
- Designed for formulations targeting the appearance of fine lines and a less smooth-looking texture.
- Often combined with other cosmetic peptides for a multi-angle anti-aging approach.
3. Supports Elasticity & a Bouncy Skin Feel
- Helps maintain a supple, bouncy skin feel in daily care.
- Works well in elasticity-positioned concepts alongside humectants and other peptides.
4. Helps Support Hydration & a Smooth-Looking Surface
- Complements humectants such as glycerin and hyaluronic acid for a well-hydrated appearance.
- Helps skin look smoother, fresher and more even when used as part of a daily routine.
Applications
- Anti-Aging Serums & Ampoules – High-performance concentrates targeting loss of firmness, elasticity and the appearance of fine lines.
- Firming & Elasticity Formulations – Products designed to support a bouncy, resilient skin feel.
- Eye Contour Creams & Serums – Gentle yet effective formulations for the delicate eye area.
- Lip Care Products – Caring formulations for the lip area.
- Oil-Based & Anhydrous Anti-Aging Products – Serums and balms where oil-compatible peptides are preferred.
- Daily Moisturizers & Creams – Everyday anti-aging care for all skin types.
- Combination / Multi-Peptide Concepts – Formulations combining Palmitoyl Hexapeptide-12 with other cosmetic peptides for comprehensive anti-aging benefits.
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FAQ
Q: What is Palmitoyl Hexapeptide-12?
A: Palmitoyl Hexapeptide-12 is a synthetic biomimetic lipopeptide composed of six amino acids with the sequence Pal-Val-Gly-Val-Ala-Pro-Gly (Pal-VGVAPG). It is the palmitoylated form of an elastin-derived peptide fragment, widely used in firming and elasticity-positioned cosmetic formulations.
Q: How does Palmitoyl Hexapeptide-12 differ from other signal peptides?
A: Unlike collagen-focused cosmetic peptides, Palmitoyl Hexapeptide-12 is based on the elastin-derived VGVAPG sequence - the protein associated with skin's elasticity and "snap-back" ability. It belongs to the matrikine-type signal peptides, which are derived from extracellular matrix proteins.
Q: What documentation is available for this product?
A: Each shipment is supplied with a Certificate of Analysis (COA), Material Safety Data Sheet (MSDS) and specification sheet. Additional documentation can be provided on request for your compliance review.
Q: Is Palmitoyl Hexapeptide-12 approved for cosmetic use in China?
A: Yes. It is listed in the Inventory of Used Cosmetic Ingredients (2021 Edition) as Item No. 08739. It is not classified as a prohibited substance under the Cosmetic Safety Technical Specification (2015 Edition).
Q: What is the solubility of Palmitoyl Hexapeptide-12?
A: Palmitoyl Hexapeptide-12 is soluble in water, glycols, oils and DMSO. The palmitoyl chain makes it particularly compatible with oil-based, anhydrous and oil-in-water formulations.
Q: What are the recommended usage levels?
A: Recommended usage varies by application:
- Anti-aging serums: 0.5% – 2%
- General leave-on products: 0.0004% – 0.05% (clinical efficacy demonstrated at 0.0004%)
- General range: 0.01% – 0.5%
- Maximum IECIC-listed use level: 3% (leave-on body products)
Please confirm the applicable usage limit for your target market before finalizing your formula.
Q: At what stage should Palmitoyl Hexapeptide-12 be added to formulations?
A: Add during the cooling phase (below 40°C – 45°C) at the final stage of formulation to preserve peptide bioactivity.
Q: What is the optimal pH range for stability?
A: Palmitoyl Hexapeptide-12 is stable at pH 4.0 – 7.5. Avoid mixing with strongly acidic (pH <3) or strongly alkaline (pH >9) ingredients, as this may affect peptide stability.
Q: What ingredients work well with Palmitoyl Hexapeptide-12?
A: Palmitoyl Hexapeptide-12 is commonly combined with:
- Vitamin C (ascorbic acid) or retinol derivatives – for anti-aging positioned formulas
- Niacinamide (vitamin B3) – for radiance and evenness-positioned formulas
- Hyaluronic acid and ceramides – for hydration and a comfortable skin feel
- Other cosmetic peptides, such as Palmitoyl Tripeptide-1 – for multi-peptide concepts
Q: What should be avoided when formulating with Palmitoyl Hexapeptide-12?
A: Avoid:
- Strongly acidic (pH <3) or strongly alkaline (pH >9) conditions
- High concentrations of metal ions (e.g., zinc sulfate) – may cause precipitation
Q: What is the difference between Palmitoyl Hexapeptide-12 and Hexapeptide-12 (non-palmitoylated)?
A: Palmitoyl Hexapeptide-12 is the lipidated (palmitoylated) version of the elastin-derived VGVAPG hexapeptide. The palmitoyl chain improves compatibility with lipid-rich and oil-based formulations. Non-lipidated VGVAPG is primarily used in research settings, while the palmitoylated version is designed specifically for cosmetic formulation compatibility.
How To Contact Us?
For bulk inquiries, samples or custom specifications, please contact our sales team. We look forward to partnering with you for high-quality Palmitoyl Hexapeptide-12 Powder that meets your exact requirements.
If you need this product for your product lines, please contact us at ella.zhang@huilinbio-tech.com.
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