Xi'an Huilin Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of cetyl tranexamate hcl powder in China. With abundant experience, we are committed to providing high quality natural products with competitive price. Please feel free to wholesale bulk pure cetyl tranexamate hcl powder for sale here from our factory.
Cetyl Tranexamate HCl (TXC) Powder | Oil-Soluble Brightening Agent for Skincare | 98% Purity
Product Overview
Cetyl Tranexamate HCl (also known as TXC, Cetyl Tranexamate Hydrochloride) is a next-generation, oil-soluble derivative of tranexamic acid engineered for superior skin brightening and anti-hyperpigmentation efficacy. By combining the proven benefits of tranexamic acid with a cetyl (fatty) chain, this advanced ingredient offers significantly enhanced skin penetration and stability compared to its water-soluble counterpart. It is designed to target stubborn dark spots, melasma, and post-inflammatory hyperpigmentation (PIH) at their source, making it a powerful and sought-after active for high-performance cosmetic formulations.
With a purity of ≥98%, our cosmetic-grade Cetyl Tranexamate HCl powder is ideal for formulators developing premium brightening serums, anti-aging creams, and professional-grade spot-correcting treatments.
Key Specifications
| Product Name | Cetyl Tranexamate HCl (TXC) |
| INCI Name | CETYL TRANEXAMATE HCL |
| CAS No. | 913541-96-5 |
| Molecular Formula | C₂₄H₄₈ClNO₂ |
| Molecular Weight | 418.096 g/mol |
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white crystalline powder or flakes |
| Solubility | Oil-soluble |
| Grade | Cosmetic Grade |
| Shelf Life | 2 years |
| Storage | Sealed, dry, cool place |
| MOQ | 1 kg (samples available) |
| Packaging | 1 kg aluminum foil bag / 25 kg fiber drum |
Mechanism of Action
The power of Cetyl Tranexamate HCl lies in its multi-modal and targeted approach to skin brightening:
- Enhanced Skin Penetration: The lipophilic cetyl tail allows the molecule to easily dissolve into and pass through the skin's lipid barrier, ensuring effective delivery to the target cells in the epidermis.
- Inhibition of Melanocyte Activation: Once delivered, it works by competitively inhibiting the interaction between keratinocytes and melanocytes. It specifically blocks the binding of plasminogen to keratinocytes in the skin, which is a key trigger for UV-induced pigmentation. By reducing plasmin activation, it suppresses the production of prostaglandins and α-MSH, two critical signals that stimulate melanocytes to produce excess melanin.
- Dual Targeting: Cetyl Tranexamate HCl simultaneously targets melanin (dark spots) and hemoglobin (red spots), reducing both pigmentation and vascular dilation by inhibiting inflammatory mediators such as prostaglandins and platelet activating factors.
- Multi-Pathway Intervention: This mechanism operates independently from, and synergistically with, traditional tyrosinase inhibitors, providing a more comprehensive approach to controlling hyperpigmentation.
Key Benefits of Cetyl Tranexamate HCl
- Potent Brightening & Spot-Correcting: Effectively reduces the appearance of post-inflammatory hyperpigmentation (PIH), melasma, sun spots, and age spots for a more uniform complexion.
- Superior Efficacy vs. Tranexamic Acid: The cetyl esterification dramatically improves skin penetration. Studies indicate Cetyl Tranexamate HCl is considered up to 60 times more effective at lightening the skin compared to standard tranexamic acid. It allows for a lower use concentration to achieve superior results.
- Improved Stability & Formulation Flexibility: Its lipid-soluble nature provides excellent stability in anhydrous and oil-based systems, offering more formulation options for chemists.
- Anti-Inflammatory Properties: Helps calm the skin, reducing redness and inflammation associated with acne and other skin conditions, which also contributes to preventing PIH.
- Safe for Sensitive Skin: Well-tolerated and non-irritating at recommended use levels, making it suitable for long-term use on various skin types.
Applications
Cetyl Tranexamate HCl is ideal for a range of high-end skincare products:
- Targeted Serums & Ampoules: As a star active in concentrated treatments for hyperpigmentation
- Brightening & Whitening Creams: Incorporated into day/night creams for all-over brightening and maintenance
- Anti-Aging Formulations: Used in products that address both wrinkles and sun damage-related discoloration
- Professional Treatment Products: Found in clinical-grade products for melasma and spot correction
Formulation Guide
Recommended Usage Levels
- Recommended concentration: 0.5% – 3.0% in finished formulations
- Optimal pH range: 5.5 – 7.0
- Patch test: 3% concentration has been tested without skin allergy or irritation
Solubility & Incorporation
- Solubility: Oil-soluble. Dissolves in oils, glycols, and lipid phases
- Dissolution ratio: Approximately 1:4 or 1:5 (TXC to solvent) is typically required, along with mild heat
- Recommended procedure: Combine Cetyl Tranexamate HCl with the oil phase or glycol, heat to 75-85°C with mixing to dissolve. Add the water phase and emulsify
Synergistic Combinations
- With Niacinamide: Niacinamide inhibits melanosome transfer, while Cetyl Tranexamate HCl targets melanin production at the source
- With Vitamin C derivatives: Enhances antioxidant protection and brightening efficacy
- With Retinoids: Addresses both pigmentation and textural concerns
- With Alpha Arbutin or Kojic Acid: Multi-pathway approach to melanin inhibition
Market Trends
The global Cetyl Tranexamate Hydrochloride market is experiencing significant growth. Valued at approximately USD 0.15 billion in 2024, it is projected to reach USD 0.45 billion by 2034, registering a CAGR of 12.0%. The Asia-Pacific region is expected to lead this growth, driven by increasing consumer demand for advanced brightening ingredients and the rising popularity of K-beauty and J-beauty formulations.
As consumers become more ingredient-savvy, the demand for oil-soluble, high-penetration actives like Cetyl Tranexamate HCl continues to rise. This ingredient is increasingly featured in premium skincare lines targeting hyperpigmentation, melasma, and uneven skin tone.
Why Choose Our Cetyl Tranexamate HCl?
- High Purity: ≥98% HPLC-verified purity with batch-to-batch consistency
- Cosmetic Grade: Meets international cosmetic ingredient standards
- Competitive Pricing: Direct from manufacturer with flexible MOQ starting at 1 kg
- Full Documentation: Comprehensive COA, MSDS, and technical data sheets available
- Technical Support: Expert formulation guidance and stability testing support
- Global Shipping: Reliable logistics with DHL, FedEx, UPS, air freight, and sea freight
Frequently Asked Questions
Q: What is the difference between Cetyl Tranexamate HCl and Tranexamic Acid?
A: Cetyl Tranexamate HCl is an oil-soluble derivative of tranexamic acid. The addition of a cetyl (fatty) chain dramatically improves skin penetration and stability. Studies indicate it can be up to 60 times more effective at lightening the skin compared to standard tranexamic acid. It requires lower concentrations to achieve superior results and is more stable in oil-based formulations.
Q: Is Cetyl Tranexamate HCl safe for sensitive skin?
A: Yes. Cetyl Tranexamate HCl is well-tolerated and non-irritating at recommended use levels (0.5%–3.0%). Patch tests at 3% concentration have shown no skin allergy or irritation, making it suitable for long-term use on various skin types.
Q: What is the recommended usage level for Cetyl Tranexamate HCl in skincare formulations?
A: The recommended concentration is 0.5% to 3.0% in finished formulations. The optimal pH range is 5.5 to 7.0. For best results, it can be combined with niacinamide, vitamin C derivatives, or other brightening actives.
Q: Is Cetyl Tranexamate HCl water-soluble or oil-soluble?
A: Cetyl Tranexamate HCl is oil-soluble. It dissolves in oils, glycols, and lipid phases. The addition of a cetyl chain makes it lipophilic, allowing it to penetrate the skin's lipid barrier more effectively than water-soluble tranexamic acid.
Q: What skin concerns does Cetyl Tranexamate HCl address?
A: Cetyl Tranexamate HCl is primarily used to treat hyperpigmentation, including melasma, post-inflammatory hyperpigmentation (PIH), sun spots, age spots, and uneven skin tone. It also has anti-inflammatory properties that help calm redness and prevent further pigmentation.
Q: Can Cetyl Tranexamate HCl be combined with other brightening ingredients?
A: Yes. Cetyl Tranexamate HCl works synergistically with niacinamide (which inhibits melanosome transfer), vitamin C derivatives (antioxidant protection), retinoids, and other tyrosinase inhibitors like alpha arbutin and kojic acid. This multi-pathway approach provides more comprehensive pigmentation control.
Q: What is the CAS number of Cetyl Tranexamate HCl?
A: The CAS number of Cetyl Tranexamate HCl is 913541-96-5. Its INCI name is CETYL TRANEXAMATE HCL, and its IUPAC name is Cyclohexanecarboxylic acid, 4-(aminomethyl)-, hexadecyl ester, hydrochloride (1:1), trans-.
Q: What is the market outlook for Cetyl Tranexamate HCl?
A: The global Cetyl Tranexamate Hydrochloride market was valued at approximately USD 0.15 billion in 2024 and is projected to reach USD 0.45 billion by 2034, with a CAGR of 12.0%. Growth is driven by increasing demand for advanced brightening ingredients, particularly in the Asia-Pacific region.
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Quality Standard
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Appearance
White or off-white solid powder
Content
≥98%
Loss on drying
≤0.50%
Solubility
Oil-soluble
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Certification
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Packaging
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Shipping
How to pay
Contact Us
Ready to incorporate high-purity Cetyl Tranexamate HCl into your skincare formulations?
Contact us today to request a free sample, obtain a Certificate of Analysis (COA), or discuss custom specifications and bulk pricing.
Email: ella.zhang@huilinbio-tech.com
References
- Maeda, K., & Tomita, Y. (2007). "Mechanism of the inhibitory effect of tranexamic acid on melanogenesis in cultured human melanocytes in the presence of keratinocyte-conditioned medium." Journal of Health Science, 53(4), 389-396.
- Chen, T., Xue, J., & Wang, Q. (2024). Tranexamic Acid for the Treatment of Hyperpigmentation and Telangiectatic Disorders Other Than Melasma: An Update. Clinical, Cosmetic and Investigational Dermatology, *17*, 2151–2163.
Why choose us?
- Our processes and technologies are designed to produce the best results.
- We believe that through our continuous efforts and pursuit, we will be able to achieve mutual benefit and win-win with our customers.
- We are a Chinese-based factory that caters to the needs of both suppliers and manufacturers.
- We effectively take customers as the center, establish advanced service mode, and fully meet the real and potential needs of customers.
- We understand the importance of listening to our customers' needs.
- Our company has reached the international advanced level with technological innovation as the forerunner.
- Our Cosmetic Raw Materials are made to stringent quality standards.
- Synergy is an organizational capability that reflects our focus on teamwork, win-win and inclusion.
- Our outstanding products and service are a testament to our hard work and dedication.
- We will continue improving and strengthening the quality management system to ensure that our Cetyl Tranexamate HCl meets the highest industry standards.
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