Introduction
Linaclotide (CAS 851199-59-2) is a synthetic 14-amino acid peptide structured with three disulfide bonds, designed as a guanylate cyclase-C (GC-C) receptor agonist [1]. It is structurally related to the naturally occurring guanylin peptide family and has been extensively studied for its role in modulating intestinal fluid secretion and pain signaling pathways [2]. As a research compound, it provides valuable insights into gastrointestinal physiology and receptor signaling mechanisms.
Physicochemical Properties
| Property | Description |
|---|---|
| Product Name | Linaclotide |
| Product Appearance | White to off-white powder |
| Molecular Formula | C₅₉H₇₉N₁₅O₂₁S₆ |
| Molecular Weight | 1526.8 g/mol |
| CAS NO | 851199-59-2 |
| Purity (HPLC) | >99.0% |
| Shelf Life | 36 months under recommended storage |
| Solubility | Soluble in water or dilute acetic acid |
| Storage | Store at -20°C, protect from light and moisture |
Characteristics
- High Purity: >99.0% verified by HPLC and LC-MS
- Stability: Maintains stability under recommended storage conditions
- Synthetic Origin: Ensures consistency and avoids biological contaminants
- Research Grade: Suitable for in vitro and animal model studies
Potential Benefits (Research Insights)
Note: These insights are derived from preclinical research findings. This product is for research purposes only and not for human consumption.
Research studies have demonstrated several interesting properties of Linaclotide [2,3]:
- Receptor Activation: Acts as a potent agonist of guanylate cyclase-C (GC-C) receptors in intestinal epithelial cells
- Fluid Secretion Modulation: Increases intracellular cGMP levels, leading to enhanced fluid secretion
- Pain Signaling Research: Shown potential in studying visceral pain pathways in experimental models
- Ion Transport Studies: Useful for investigating chloride and bicarbonate secretion mechanisms
Applications
Linaclotide is used in various research applications including [1,3]:
- Gastrointestinal Research: Studying intestinal fluid secretion and motility mechanisms
- Receptor Signaling Studies: Investigating GC-C receptor activation and downstream effects
- Drug Development Research: Serving as a reference compound for developing gastrointestinal therapeutics
- Physiological Studies: Exploring ion transport mechanisms across epithelial barriers
- Pain Research: Investigating visceral pain signaling pathways in experimental models
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Packaging & Shipping
Certification
Frequently Asked Questions (FAQ)
Q: Is Linaclotide approved for human use?
A: While pharmaceutical formulations exist, this product is strictly for research purposes only.
Q: What is the shipping and storage requirement?
A: Products are shipped with cold packs and should be stored at -20°C upon receipt.
Q: Can I request analytical data?
A: Yes, Certificate of Analysis is available upon request for research verification.
Q: Do you offer custom synthesis?
A: Yes, custom synthesis and bulk quantities are available for research purposes.
How To Contact Us?
If you need this product for your research requirements, please get in touch with us at ella.zhang@huilinbio-tech.com to discuss sourcing Linaclotide Peptide for research purposes.
References
[1] National Center for Biotechnology Information. PubChem Compound Summary for CID 16140508, Linaclotide. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Linaclotide
[2] Bryant, A. P., & Busby, R. W. (2010). Linaclotide: a new direction in the treatment of irritable bowel syndrome with constipation. Current Opinion in Investigational Drugs, 11(5), 572-580.
[3] Eutamene, H., & Bueno, L. (2007). Role of probiotics in correcting abnormalities of colonic flora induced by stress. Gut, 56(11), 1495-1497.
Disclaimer
This product is intended for research purposes only in a laboratory setting. It is not intended for diagnostic, therapeutic, or human use. It is the purchaser's responsibility to verify compliance with all local, state, federal, and international regulations regarding the possession and use of this material. Xi'an Huilin Biological Technology Co., Ltd. assumes no liability for misuse, unauthorized handling, or damages resulting from the use of this product.
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