What is andrographolide?
Andrographolide Powder is a diterpenoid lactone compound extracted from Andrographolide, which is one of the main effective components of Andrographolide in Chinese medicine. It is odorless and bitter in appearance. Andrographolide dissolves Chemicalbook in boiling ethanol, is slightly soluble in methanol or ethanol, very slightly soluble in chloroform, and almost insoluble in water or ether. It has the effect of dispelling heat and detoxifying, anti-inflammatory and analgesic, and has special effect on bacterial and viral upper respiratory tract infection and dysentery, which is known as natural antibiotic medicine
Andrographolide benefits
1. Disease-resistant protozoa.Animal experiments showed that both andrographolide and neoandrographolide had the effect of inhibiting and delaying the increase of body temperature caused by diplococcus pneumoniae or hemolytic B streptococcus, but the effect of andrographolide was stronger than that of neoandrographolide. In vitro experiments showed that andrographitis had certain anti-HIV effect.
2. Antipyretic effect. Andrographolide has different antipyretic effects on endotoxin fever, pneumococcus or hemolytic streptococcus fever in rabbits. The antipyretic effects of andropanthoides a, B, C and butin on rabbits with fever caused by typhoid and paratyphi vaccine or on mice with fever caused by 2, 4-dinitrophenol were decreased successively.
3. Andrographolide Powder has Anti-inflammatory effect. A, B, C and butin of grapholocentesis have anti-inflammatory effects to varying degrees. 1g/kg administration can inhibit the increase of capillary permeability in the skin or abdominal cavity of mice caused by xylene or acetic acid, and reduce the amount of acute exudate caused by soybean oil in Selye granulation sac, but has no obvious effect on the proliferation of granulation tissue. It can inhibit the development of foot swelling in egg white rats, but the effect disappears after excision of adrenal gland. The anti-inflammatory effect of butyl was the strongest, followed by propyl, alpha-methyl and ethol.
4. Influence on immune function of the body.It has been reported that andrographitis may have an effect on some aspects of cellular immunity. Its decoction can improve the phagocytic ability of Staphylococcus aureus in vitro, and oral administration of andrographitis can enhance the delayed hypersensitivity of skin caused by old tuberculin. Andrographitis preparations (including esters and ketones) can increase the level of serum lysozyme and enhance the phagocytosis ability of peritoneal macrophages and neutrophils in mice. The phagocytic ability of peripheral blood phagocytic cells to pneumococcus or staphylococcus aureus can be increased by continuous administration of andrographolide sulfonate in rabbits or mice, and the function of phagocytic cells can also be enhanced by andrographolide injection and Xiyanping injection. Dehydrated androholide half succinate also inhibited delayed hypersensitivity induced by 2, 4-dinitrochlorobenzene in mice.
5. Anti-fertility effect. Andrographitis has an obvious effect on pregnancy interruption. Andrographitis oral can make mice contraceptive, pregnant rabbit abortion. Intraperitoneal injection of water decoction had a significant stopping effect on implantation, early pregnancy, middle pregnancy and late pregnancy in mice. Intramuscular injection, subcutaneous injection, irrigation, intraperitoneal injection, intravenous injection and intrauterine injection can produce anti-early pregnancy effect, among which intraperitoneal injection, intravenous injection and intrauterine injection have the best effect. Intrauterine injection, the dosage is small, the effect is good. If the release of exogenous progesterone or luteinizing hormone (LH-RH) and andrographitis are injected at the same time, abortion can be prevented, suggesting that andrographitis may have an anti-progesterone effect in vivo, thus causing abortion. It has been suggested that andrographitis can inhibit the growth of placental villus trophoblast cells cultured in vitro. The study says: Some semi-synthetic derivatives of andrographolide also have different degrees of anti-early pregnancy effect. Dehydroandrographolide derivative - Perfor-4 has good anti-early pregnancy effect on both mice and rats, which is worth further study as a new contraceptive drug. This drug has a significant effect on placental trophoblastic leaf cells, and can make placental villus atrophy and cell number decrease. Syncytic cells and Langham cells disappeared, interstitial edema and hemorrhage.
6. Gallbladder and liver protection. Andrographitis has good gallbladder effect on rats, and can increase liver weight and shorten sleep time caused by sodium cyclohexanbarbital. Andrographolide pre-administration can counteract the hepatotoxicity caused by carbon tetrachloride, D-galactosamine and acetamide phenol, and can significantly reduce the levels of SGPT, SGOT, SALP and HTG, respectively. It has been reported that the methanol extract of Andrographitis is toxic and can promote the death of rats with liver injury.
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Clinical Application
Related medicinal products
For bacillary dysentery, leptospirosis, meningitis, pneumonia, adrenal cortex enhancement, upper respiratory tract infection. According to the needs of clinical viral infection emergency, different hydrophilic groups were introduced into the lactone structure of this product to enhance its water solubility and improve the curative effect. Therefore, a variety of andrographolide injections have been prepared. The widely used andrographolide, Andrographolide and Lianbi injection are representative drugs of this class, which have been listed as one of the essential drugs in emergency department by Ministry of Health and State Administration of Traditional Chinese Medicine.
Adverse reactions
Andrographolide taken orally can cause vomiting due to extreme bitterness. This product and a variety of preparations can cause epigastric discomfort and loss of appetite when taken orally in large doses. Drug eruption, epigastric pain and anaphylactic shock have been reported after intramuscular injection of andrographitis injection. Symptoms of severe reaction can be seen: chest tightness, shortness of breath, pale face, blue lips, cold sweat, weak pulse, blood pressure drop, etc. Those with mild reactions generally show abdominal pain, vomiting, asthma, urticaria, papules, dizziness, head swelling, sneezing and so on. The time of reaction is immediate, there are also 5 ~ 20 minutes after injection, after the rescue, generally in 5 ~ 45 minutes gradually improved, individual after 24 hours to recover. There are also reports of acute amniotic fluid blockage caused by the exchange of andrographitis amniotic fluid to induce labor
Method of detection
Dry weight loss
Take the product, dry at 105℃ to constant weight, weight loss not more than 1.0% (Chinese Pharmacopoeia 2000 Edition II Appendix Ⅶ L).
Hot burning residue
Not more than 0.1% (Appendix Ⅶ N of Part II, Chinese Pharmacopoeia, 2000).
Determination of content
Take about 20mg of the product, weigh it accurately, put it in a 100ml measuring bottle, add ethanol to make it dissolve, cool it, and dilute it to the scale, shake well, take 5ml precision, put it in a 50ml measuring bottle, add ethanol to dilute it to the scale, shake well, as the test product solution: After drying at 105℃ to constant weight, andrographolide was used as the reference solution, and the solution containing 20μg per 1ml was prepared by adding ethanol. Take the above two solutions, spectrophotometric method (Chinese Pharmacopoeia 2000 Edition of Part II Appendix ⅣA), at the wavelength of 224nm to determine the absorption, calculation, obtained.
How to contact us?
Our company is a professional supplier of semi-finished raw materials, including plant extract, fruit and vegetable powder, cosmetics, tablet candy and other kinds of products; Our products are supplied directly from the manufacturer, so the price is very favorable, and the quality is guaranteed, so you can rest assured to buy. Today, our company is selling Andrographolide Powder, which is a high-quality additive to health care products, medicine, skin care and other products.
If you are interested in this product and want to know more about it, you can consult our account manager through the international website or email, our email address is ella.zhang@huilinbio-tech.com; Our factory is located in Room 706, Building B, Fengze Science Park, No.170 West Street, Yanta District, Xi 'an City, Shaanxi Province.