Introduction
Panax Notoginseng Saponins (PNS) are the primary bioactive constituents extracted from the dried root and rhizome of Panax notoginseng (Burk.) F.H. Chen, a renowned medicinal plant in the Araliaceae family that has been used in traditional Chinese medicine for over 600 years. PNS comprises a complex mixture of dammarane-type triterpenoid saponins, with the five major components-ginsenoside Rb1, Rg1, Re, Rd, and notoginsenoside R1-accounting for approximately 90% of the total saponin content.
PNS is well-documented for its multifaceted pharmacological profile: promoting blood circulation, removing blood stasis, inhibiting platelet aggregation, and increasing cerebral blood flow. Modern research has further revealed its antioxidant, anti-inflammatory, lipid-lowering, neuroprotective, and cardioprotective properties. The diverse biological activities of PNS are attributed to the synergistic effects of its multiple saponin components, each contributing distinct yet complementary actions.
We offer a comprehensive range of PNS specifications-from total saponins 5% (suitable for whole-herb formulations) to total saponins 85% (meeting injection-grade requirements), and ginsenoside Rb1 from 5% to 98% purity-enabling formulators to select the optimal grade for their specific application, whether in dietary supplements, pharmaceuticals, functional foods, or research.
Specifications & Applications Guide
1. Total Saponins Series
| Specification | Key Components | Purity Level | Recommended Applications | Key Considerations |
|---|---|---|---|---|
| Total Saponins ≥5% | Rb1, Rg1, R1 (total content of three saponins ≥5.0%) | Low | Whole-herb dietary supplements, traditional decoction-style capsules, cost-effective formulations | Matches the saponin content of raw Panax notoginseng root powder; ideal for "whole-herb equivalent" products |
| Total Saponins ≥10% | Rb1, Rg1, R1, Re, Rd | Low–Medium | Dietary supplements (capsules, tablets), functional foods and beverages | Standard industrial extraction grade; balanced between potency and cost; widely used in nutraceuticals |
| Total Saponins ≥30% | Rb1, Rg1, R1, Re, Rd | Medium | High-potency dietary supplements, wellness shots, functional beverages | Concentrated bioactive profile; suitable for products requiring higher active content per dose |
| Total Saponins ≥50% | Rb1, Rg1, R1, Re, Rd | Medium–High | Premium dietary supplements, sports nutrition, clinical nutrition | High concentration; ideal for small-formulation products with stringent potency requirements |
| Total Saponins ≥75% (Oral Grade) | Rb1 ≥30%, Rg1 ≥25%, R1 ≥5%, Re ≥2.5%, Rd ≥5% | High | Oral pharmaceuticals (tablets, capsules), high-end dietary supplements | Meets Chinese Pharmacopoeia standards for oral pharmaceutical use; five-saponin profile ensures synergistic bioactivity |
| Total Saponins ≥80% | Rb1, Rg1, R1, Re, Rd | High | High-end dietary supplements, cosmetic formulations, pharmaceutical intermediates | Premium purity grade; suitable for products requiring concentrated active ingredients |
| Total Saponins ≥85% (Injection Grade) | Rb1 ≥30%, Rg1 ≥25%, R1 ≥5%, Re ≥2.5%, Rd ≥5% | Very High | Injection-grade pharmaceuticals (sterile solutions for IV administration); high-purity research | Strictly complies with Chinese Pharmacopoeia standards for parenteral use; rigorous heavy metal and impurity controls required |
2. Ginsenoside Rb1 Series
| Specification | Purity Level | Recommended Applications | Key Considerations |
|---|---|---|---|
| Ginsenoside Rb1 ≥5% | Low | Dietary supplements, functional foods, cosmetic emulsions | Entry-level Rb1 specification; suitable for general wellness products |
| Ginsenoside Rb1 ≥10% | Low–Medium | Targeted supplements for cardiovascular and neuroprotective benefits | Higher Rb1 content for focused bioactivity; often combined with other saponins for synergistic effects |
| Ginsenoside Rb1 ≥20% | Medium | High-potency dietary supplements, sports nutrition, cognitive health formulations | Balanced purity and cost; ideal for products emphasizing Rb1-specific benefits |
| Ginsenoside Rb1 ≥30% | Medium–High | Premium dietary supplements, pharmaceutical research, advanced formulations | High Rb1 concentration for focused therapeutic applications |
| Ginsenoside Rb1 ≥50% | High | High-potency nutraceuticals, clinical research, specialized formulations | Near-pharmaceutical grade; for products requiring concentrated single-saponin activity |
| Ginsenoside Rb1 ≥90% | Very High | Pharmaceutical research, high-end nutraceuticals, analytical standards | Exceptional purity; for specialized applications requiring premium-grade Rb1 |
| Ginsenoside Rb1 ≥98% | Ultra-High | Research & development (apoptosis inhibitor studies, neurological disorder research), analytical reference standards, high-precision pharmacological studies | Crystalline solid; used as a reference compound for HPLC analysis; also in advanced biomedical research for anti-inflammatory, neuroprotective, and cardioprotective studies |
Certificate of Analysis (COA) – Representative (Total Saponins ≥75% / Oral Grade)
| Item | Specification | Result | Method |
|---|---|---|---|
| Physical Description | |||
| Appearance | Light yellow to yellowish-brown fine powder | Conforms | Visual |
| Odor | Characteristic, slightly bitter | Conforms | Organoleptic |
| Particle Size | 100% pass 80 mesh | Conforms | Screening |
| Chemical Tests (HPLC) | |||
| Ginsenoside Rb1 | ≥30.0% | 31.20% | HPLC |
| Ginsenoside Rg1 | ≥25.0% | 26.50% | HPLC |
| Notoginsenoside R1 | ≥5.0% | 5.30% | HPLC |
| Ginsenoside Re | ≥2.5% | 2.80% | HPLC |
| Ginsenoside Rd | ≥5.0% | 5.10% | HPLC |
| Total of Five Saponins | ≥75.0% (oral) | 78.90% | HPLC |
| Loss on Drying | ≤5.0% | 3.20% | USP <731> |
| Ash Content | ≤5.0% | 4.10% | USP <281> |
| Heavy Metals | |||
| Lead (Pb) | ≤5.0 mg/kg | Conforms | ICP-MS |
| Cadmium (Cd) | ≤0.3 mg/kg | Conforms | ICP-MS |
| Arsenic (As) | ≤2.0 mg/kg | Conforms | ICP-MS |
| Mercury (Hg) | ≤0.2 mg/kg | Conforms | ICP-MS |
| Copper (Cu) | ≤20.0 mg/kg | Conforms | ICP-MS |
| Microbiological Control | |||
| Total Plate Count | ≤10,000 cfu/g | Conforms | USP <2021> |
| Yeast & Mold | ≤1,000 cfu/g | Conforms | USP <2021> |
| E. coli | Negative | Negative | USP <2022> |
| Salmonella | Negative | Negative | USP <2022> |
| Conclusion | Conforms to specification |
Note: Full COAs for all specifications (Total Saponins 5%, 10%, 30%, 50%, 80%, 85%; Rb1 5%–98%) are available upon request.
Panax Notoginseng Saponins benefits
1. Core Benefits of PNS (All Specifications)
- Cardiovascular & Cerebrovascular Protection: Promotes blood circulation, removes blood stasis, inhibits platelet aggregation, and increases cerebral blood flow. Used for cerebral vascular sequelae, retinal central vein occlusion, and anterior chamber hemorrhage.
- Antioxidant Protection: Scavenges free radicals and reduces oxidative stress through Nrf2 pathway activation.
- Anti-Inflammatory Activity: Reduces inflammatory responses by inhibiting NLRP3 inflammasome activation and downregulating pro-inflammatory mediators.
- Myocardial Ischemia Protection: Dilates coronary vessels, increases coronary blood flow, and protects against myocardial ischemia and arrhythmias.
- Neuroprotection: Protects against cerebral ischemia-reperfusion injury and shows potential in stroke-related conditions.
2. Specification-Specific Benefits
| Specification | Distinctive Advantages |
|---|---|
| Total Saponins ≥5% | Matches natural root profile; ideal for "whole-herb equivalent" products; most cost-effective |
| Total Saponins ≥10%–50% | Balanced potency and cost; consistent batch-to-batch standardization |
| Total Saponins ≥75% | Meets pharmaceutical oral-grade standards; five-saponin profile ensures comprehensive bioactivity |
| Total Saponins ≥85% | Injection-grade purity; highest level of refinement for parenteral applications |
| Ginsenoside Rb1 ≥5%–30% | Targeted Rb1 bioactivity (neuroprotective, cardioprotective, anti-inflammatory) |
| Ginsenoside Rb1 ≥50%–90% | High-purity Rb1 for focused therapeutic applications and research |
| Ginsenoside Rb1 ≥98% | Ultra-high purity for analytical standards and advanced biomedical research |
What are Panax Notoginseng Saponins Used for?
1. Dietary Supplements
Total Saponins 5%–30%: Whole-herb capsules, tablets, and powder blends for general cardiovascular wellness
Total Saponins 50%–75%: High-potency supplements for targeted cardiovascular and cerebrovascular support
Ginsenoside Rb1 5%–30%: Specialized supplements for neuroprotection, anti-fatigue, and cognitive support
2. Pharmaceuticals
Total Saponins ≥75%: Oral solid dosage forms (tablets, capsules)
Total Saponins ≥85%: Injection-grade formulations (sterile solutions for intravenous administration)
3. Functional Foods & Beverages
Total Saponins 5%–30%: Fortified wellness drinks, health teas, functional beverages
Total Saponins 10%–50%: Nutritional bars, sports nutrition products
4. Cosmetics & Personal Care
Total Saponins ≥80%: Anti-aging serums, skin-repair creams, and rejuvenation formulations
Ginsenoside Rb1 5%–30%: High-end skincare products targeting inflammation and oxidative stress
5. Research & Development
Ginsenoside Rb1 ≥98%: Analytical reference standards, apoptosis inhibitor studies, neurological disorder research, pharmacological mechanism studies
Frequently Asked Questions (FAQ)
Q: What is the difference between "Total Saponins" and "Ginsenoside Rb1" specifications?
A: "Total Saponins" refers to the combined content of multiple saponin components-typically ginsenoside Rb1, Rg1, Re, Rd, and notoginsenoside R1-and represents the overall bioactive potency of the extract. "Ginsenoside Rb1" is a specific, individual saponin component within the total saponin mixture. Products standardized to Rb1 content ensure a minimum level of this particular bioactive compound, which is especially important for applications where Rb1's specific actions (neuroprotection, cardioprotection, anti-inflammation) are desired.
Q: What is the difference between ≥75% (oral) and ≥85% (injection) total saponins?
A: Both specifications meet Chinese Pharmacopoeia standards but differ in their intended use. The ≥75% specification is for oral pharmaceutical use (tablets, capsules), while the ≥85% specification is for injection-grade products (sterile solutions for intravenous administration). Injection-grade products undergo more rigorous purification and quality control, including stricter limits on impurities, endotoxins, and particulate matter.
Q: What is the recommended dosage?
A: Dosage varies by specification and intended application. For dietary supplements: Total Saponins 5%–30%: 200–500 mg/day; Total Saponins 50%–75%: 50–200 mg/day; Ginsenoside Rb1 5%–30%: 50–150 mg/day. For pharmaceutical applications, follow official product labeling and clinical guidelines. We recommend consulting with a formulation specialist for application-specific guidance.
Q: Which specification should I choose for my product?
A:
- Whole-herb equivalent supplements: Total Saponins ≥5%
- Cost-effective dietary supplements: Total Saponins 10%–30%
- High-potency supplements: Total Saponins 50%–75%
- Oral pharmaceuticals: Total Saponins ≥75% (with five-saponin profile)
- Injection formulations: Total Saponins ≥85%
- Rb1-targeted formulations: Ginsenoside Rb1 ≥5%–30%
- Research & analytical standards: Ginsenoside Rb1 ≥98%
Q: Is this product compliant with the Chinese Pharmacopoeia?
A: Yes. Our PNS products are manufactured in accordance with Chinese Pharmacopoeia standards. The ≥75% (oral) and ≥85% (injection) specifications strictly follow the pharmacopoeia requirements for total saponin content and individual saponin profiles.
Q: What certifications are available?
A: Our Panax Notoginseng Saponins products are manufactured in ISO, HACCP, KOSHER, and HALAL certified facilities with GMP-compliant production processes.
Why Choose Huilin Bio-Tech?
Your Professional Manufacturing & Sourcing Partner
We are more than a supplier - we are a comprehensive supply chain partner dedicated to high-quality ingredients, custom formulations, and finished products across multiple industries.
- Professional Manufacturer: Xi'an Huilin Bio-tech Co., Ltd. is a high-tech biotechnology company specializing in the production, R&D, and export of natural botanical extracts.
- Quality Assurance: Every batch undergoes rigorous testing for capsaicin content (HPLC), heavy metals (ICP-MS), and microbiological purity to ensure consistent quality and safety.
- Flexible Specifications: We offer a wide range of specifications from 1% to 98% capsaicin content to meet diverse application requirements.
- Customization Capabilities: We offer flexible packaging options and custom formulations to meet diverse customer requirements.
- Supply Chain Reliability: With established supply chains and robust production capacity, we ensure timely delivery and stable supply for bulk orders.
- Technical Support: Our experienced R&D team provides formulation guidance and technical support throughout your product development process.
- Global Compliance: Products are manufactured in compliance with international quality standards and regulatory requirements.
Contact Us
For inquiries, quotations, or sample requests, please contact:
Email: ella.zhang@huilinbio-tech.com
We look forward to partnering with you to bring high-quality Panax Notoginseng Saponins to your products.
References
- Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China. Total saponins specification: notoginsenoside R1 ≥5.0%, ginsenoside Rg1 ≥25.0%, ginsenoside Re ≥2.5%, ginsenoside Rb1 ≥30.0%, ginsenoside Rd ≥5.0%; total content of five saponins ≥75% for oral administration and ≥85% for injection.
- Panax notoginseng saponins against ischemic stroke: From molecule to clinic. Journal of Ethnopharmacology. PNS can regulate oxidative stress, inflammatory responses, apoptosis, ferroptosis, pyroptosis, angiogenesis, and neurogenesis in ischemic stroke.
- Ginsenoside Rb1 targets the NRF2-PPARγ-ACSL4 axis to inhibit PTECs ferroptosis. Chinese Medicine. 2026;21:19. NRF2 was verified as a direct target for Rb1's ferroptosis-inhibitory effect. Rb1 selectively inhibits lipid peroxidation by activating the NRF2-PPARγ-ACSL4 axis.
- Ginsenoside Rb1 in cardiovascular and cerebrovascular diseases: A review of therapeutic potentials and molecular mechanisms. Chinese Herbal Medicines. 2024;16(4):489-504. G-Rb1 demonstrates potential benefits on the cardiovascular system through anti-oxidation, anti-inflammatory, regulation of vasodilation, and reduction of platelet adhesion.
- Pharmacological Mechanism and Drug Research Prospects of Ginsenoside Rb1 as an Antidepressant. Antioxidants. 2025;14(2):238. Ginsenoside Rb1 regulates oxidative stress and inflammatory processes while enhancing neural plasticity, showing potential as a novel antidepressant.
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