Phloretin Powder

Plant-Derived Phloretin Powder | Cosmetic Ingredient Supplier

Phloretin powder is a new natural skin whitening agent extracted from apple peel, which has effects on various skin spots. The inhibition of tyrosinase by rhizoptin at the same concentration is better than that of arbutin and kojic acid, and can be mixed with arbutin or kojic acid, so that the inhibition rate of tyrosinase can reach 100%.

1. Antioxidant properties: Phloretin powder is rich in antioxidants, which help to neutralize free radicals and protect cells from oxidative stress.
2. Anti-inflammatory effect: phlogiston powder is said to have an anti-inflammatory effect, which can help reduce inflammatory reactions and promote health.
3. Immunoregulation: phloretin powder may regulate the immune system, which is helpful to enhance immune function and improve body resistance.
4. Anti-aging: Phloretin powder is considered to have anti-aging potential, which can help delay the cell aging process and maintain the health of the body.

1. The field of health care products: Phloretin powder is used as a health care product for people to supplement antioxidant substances and other nutrients, which is helpful to maintain overall health and promote body balance.
2. Medical field: Phloretin powder may be used in drug research and development to explore its potential role in treating inflammatory diseases, cardiovascular diseases, and other diseases.
3. Skin care products: Phloretin powder has antioxidant and anti-aging properties, so it may be added to skin care products to care for the skin and slow down the process of skin aging.
4. Food processing field: Phloretin powder may be used as a food additive to enhance the nutritional value and functionality of food, such as health food, beverages, or other food products.

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There is ‌no universally established oral dosage for phloretin powder in humans‌ due to the lack of large-scale clinical trials. Current insights derive primarily from preclinical studies:

1‌. Human Data Gap‌:

• No clinical trials define optimal human doses for specific conditions. Existing evidence relies on cellular (in vitro) and animal studies^{[1] [2]}.

‌2. Animal Studies (Extrapolated Insights)‌:

• In broiler chickens with gut inflammation, ‌200 mg/kg of feed‌ (equivalent to ‌~20–40 mg/kg body weight/day‌) significantly improved intestinal barrier function and reduced oxidative stress^[3].
• Note: ‌Animal doses do not directly translate to humans‌. Weight-adjusted conversions are theoretical and require clinical validation.

3‌. In Vitro Effective Concentrations‌:

• Studies on cells typically use ‌5–100 μM phloretin‌ to achieve antioxidant, anti-inflammatory, or skin-penetration effects^{[1] [2]}. For reference, 100 μM ≈ ‌27.4 μg/mL‌.

4‌. Commercial Supplement Practices‌:

• Brands often suggest ‌50–200 mg daily‌ (split into 1–2 doses), but these lack rigorous clinical backing. Formulations may include enhancers (e.g., nanoparticles ^[2]) to improve bioavailability.

‌5. Safety & Precautions‌:

• ‌Generally Recognized as Safe (GRAS)‌ in food sources, but concentrated powder may:

a. Inhibit drug transporters (e.g., ‌OATP2B1‌), affecting medication absorption ^[4].

b. Causes mild GI upset at high doses.

• ‌Consult a healthcare provider‌ before use if:

a. Taking medications (e.g., statins, antifungals).

b. Pregnant, breastfeeding, or with chronic conditions.

Soluble in ethanol, methanol, amyl alcohol, acetone, ethyl acetate, pyridine, glacial acetic acid, etc., insoluble in ether, chloroform, and benzene

(1) Professional suppliers: We are a professional plant extracts production, export enterprises, with nearly ten years of export experience

(2) Own factory: we can customize products for customers and provide OEM services

(3) Quality inspection: With professional testing personnel and perfect testing equipment, quality assurance

(4) Sales team: a professional sales team, 24 hours to provide service

(1) Aluminum foil bag packaging: suitable for 1 kg weight

(2) Carton packing: suitable for more than 20 kg weight

(3) Carton packing: suitable for weight less than 20 kg

(1) Express delivery: fast aging, door-to-door service

(2) Air transport: fast aging, airport to airport

(3) Shipping: slow aging, port to port

(1) What is your minimum order quantity?

Minimum starting order volume is 100 g.

(2) What are your terms of payment?

T/T, L/C, Trade guarantee, credit card, or PayPal.

(3) What's your lead time?

Usually, most of the products are in stock and can be shipped within 3-5 business days of receiving payment. If there is no stock, we will arrange shipment within 7-15 working days

(4) What about the packing?

Usually, we provide 1kg/aluminum foil bag or 25kg/bag and carton packaging.

(5)After-sales service scope of your products?

Any questions related to product quality can be contacted at any time

If you need phloretin powder or other products, please contact ella.zhang@huilinbio-tech.com

1. Zielińska, D., & Zieliński, H. (2023). Phloretin as a Functional Ingredient: Mechanisms and Health Benefits. Molecules, 28(7), 3217.
2. Ma, Y., et al. (2023). Enhanced Topical Delivery of Phloretin via Nanoemulsions for Antioxidant Skin Therapy. Pharmaceutics, 15(8), 2042.
3. Zhang, L., et al. (2022). Phloretin Attenuates Necrotic Enteritis via Modulating Gut Microbiota and Inhibiting TLR4/NF-κB Pathway. Antioxidants, 11(7), 1305.
4. Roth, M., & Obaidat, A. (2023). Potent Inhibition of OATP2B1 by Phloretin: Implications for Food-Drug Interactions. Molecular Nutrition & Food Research, 67(1), 2300001.
5. Zhang et al. (2022). Antioxidants, 11(7), 1305.
6. Roth & Obaidat (2023). Mol. Nutr. Food Res., 67(1), 2300001.

Why choose us?

• We strive to ensure our customers always receive top-quality products and services.
• Complete variety of products, excellence in quality, reasonable prices and attentive service are our advantages that differentiate us from other brands.
• Our experienced professionals work tirelessly to ensure quality and efficiency.
• Our company adheres to the business philosophy of 'responsibility wins respect, innovation wins competition', abides by the principle of honesty and mutual benefit, and contributes to the industry of Phloretin Powder.
• We use the latest technology to create the highest quality products.
• Facing the rapidly changing market, we will adhere to the industrial development strategy of strengthening the main industry and moderately diversified.
• Our success is built on our customers' satisfaction.
• We hope to become a first-class company with the most competitive production chain of the Phloretin Powder.
• Trust us to provide you with the best Cosmetic Raw Materials in the market.
• We follow the pace of development of the times and the national development strategy, and constantly explore new industrial fields.

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