Xi'an Huilin Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of pentapeptide‑18 powder in China. With abundant experience, we are committed to providing high quality natural products with competitive price. Please feel free to wholesale bulk pure pentapeptide‑18 powder for sale here from our factory.
What Is Pentapeptide-18?
Pentapeptide-18 is a synthetic biomimetic peptide composed of five amino acids, with the sequence Tyr-D-Ala-Gly-Phe-Leu-OH. It is a structurally stabilized analog of the endogenous pentapeptide Leu-enkephalin, in which the second-position glycine is replaced with D-alanine - a modification that confers enhanced resistance to proteolytic degradation and improves stability in cosmetic formulations.
Because of that stabilized structure, the peptide remains available at the skin's surface during use, which supports its role in topical products formulated to improve the appearance of expression lines. It is widely used in premium anti-aging skincare concepts, where formulators look for a peptide that pairs well with signal peptides and other carrier peptides.
Our Pentapeptide-18 Powder is manufactured through Solid-Phase Peptide Synthesis (SPPS) under rigorous quality control. The result is a consistently pure, stable, and highly consistent powder that meets the quality requirements of prestige skincare brands worldwide.
Key Features & Advantages
- Biomimetic Peptide Design – A stabilized analog of Leu-enkephalin, developed for topical cosmetic use in products targeting the appearance of expression lines.
- High Purity – Available in ≥98% and ≥95% purity (HPLC + MS).
- Enhanced Stability – The D-Ala² substitution provides superior resistance to enzymatic degradation compared with the natural peptide.
- Excellent Water Solubility – Soluble in water, glycols, and DMSO; easy to incorporate into aqueous formulations.
- Broad pH Stability – Stable at pH 4.0 – 7.5 (optimal pH 5.0 – 7.0).
- Formulation Compatibility – Designed to be combined with other cosmetic peptides, including Acetyl Hexapeptide-8, in advanced anti-aging concepts.
- Regulatory Documentation – Supported by a complete technical file (COA, MSDS, specification sheet) for your compliance review. Intended for cosmetic use only.
- Clean & Synthetic – 100% synthetic; no animal-derived ingredients; suitable for vegan and clean beauty formulations.
- Versatile Formats – Available as lyophilized powder or liquid solution.
Technical Specifications (Typical – ≥98% Grade)
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Pentapeptide-18 | – |
| CAS Number | 64963-01-5 | – |
| INCI Name | Pentapeptide-18 | – |
| Molecular Formula | C₂₉H₃₉N₅O₇ | – |
| Molecular Weight | 569.6 – 569.7 g/mol | – |
| Sequence | H-Tyr-D-Ala-Gly-Phe-Leu-OH | – |
| Appearance | White to off-white lyophilized powder | Visual |
| Assay (Purity) | ≥98.0% (HPLC) | HPLC |
| Purity (≥95% grade) | ≥95.0% (HPLC+MS) | HPLC + MS |
| Counter-Ion | TFA Salts (Acetate/HCl exchange available) | – |
| Solubility | Soluble in water, glycols, DMSO | – |
| pH Stability Range | 4.0 – 7.5 | – |
| Recommended Storage | 2°C – 8°C (short-term); -20°C (long-term) | – |
| Heavy Metals | Compliant with cosmetic standards | ICP-MS |
| Total Plate Count | ≤1,000 CFU/g | USP <61> |
| Yeast & Mold | ≤100 CFU/g | USP <2021> |
| E. coli | Negative / 10g | USP <2022> |
| Salmonella | Negative / 10g | USP <2022> |
Specifications are for reference. Please request the current COA for batch-specific data.
Pentapeptide 18 Key Skin Benefits
Pentapeptide-18 is a cosmetic peptide used in topical formulations designed to improve the appearance of expression lines.
Targets the Appearance of Expression Lines
- Formulated to help visibly smooth the look of lines caused by repeated facial movements.
- Contributes to a smoother, more rested skin appearance in leave-on products.
Focuses on Dynamic Areas – Forehead, Crow's Feet & Perioral Lines
- Designed for products targeting expression lines around the forehead, eye contour, and lip area.
- Well suited to targeted spot treatments as well as full-face formulas.
Complementary to Other Cosmetic Peptides
- Pentapeptide-18 and Acetyl Hexapeptide-8 are two distinct peptides with different, complementary modes of action on the skin surface.
- This makes them a common pairing in advanced anti-aging concepts.
Supports Hydration, Elasticity & Texture
- Beyond expression-line care, formulas containing Pentapeptide-18 can also support skin hydration, elasticity, and overall texture.
- Contributes to a smoother, more even-looking complexion.
Supported by Regulatory Documentation
- Supplied with full documentation (COA, MSDS, specification) for your regulatory review.
- Manufactured under a documented quality-management process.
- Intended for cosmetic use only.
Suitable for Sensitive Skin & Clean Beauty
- Synthetic, non-invasive, and well tolerated in topical formulations.
- No animal-derived ingredients – suitable for vegan and clean beauty concepts.
- Designed for consumers looking for effective anti-aging care without injectable treatments.
Pentapeptide-18 Applications
- Expression-Line Serums – Targeted serums for expression lines around the forehead and eye area.
- Eye Contour Creams – Gentle yet effective formulations for the delicate eye area.
- Anti-Aging Serums & Ampoules – Premium concentrates for daily at-home care.
- Day & Night Moisturizers – Daily care and mild smoothing of expression lines.
- Face, Neck & Hand Care – Multi-area anti-aging treatments.
- Hair Care – Nourishing and strengthening formulations.
- Color Cosmetics (Makeup) – Anti-aging positioning in foundations and primers.
- Lip Area Treatments – Targeted products for perioral lines.
- Daily Anti-Aging Routines – Suitable for building a complete at-home anti-aging regimen.
Company Introduction
Xi'an Huilin Bio-tech Co., Ltd. is a leading provider of premium plant extracts for health applications. We supply herb extracts, standardized extracts, and fruit/vegetable powders. Dedicated to quality and innovation, we serve global customers in the supplements, food, and cosmetic industries, advancing human health. Click here to learn more.
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FAQ
Q: What is the difference between Pentapeptide-18 and Acetyl Hexapeptide-8?
A: They are two distinct cosmetic peptides with different, complementary modes of action on the skin surface. Both are widely used in anti-aging formulations, and they are often combined in advanced concepts targeting the appearance of expression lines.
Q: Is the product suitable for vegans and vegetarians?
A: Yes. Our Pentapeptide-18 is 100% synthetic, produced via Solid‑Phase Peptide Synthesis (SPPS). No animal‑derived ingredients are used.
Q: Does it contain allergens?
A: Our Pentapeptide-18 Powder is free from major allergens including gluten, dairy, soy, eggs, fish, shellfish, peanuts, and tree nuts. Allergen declarations are available upon request.
Q: What are the recommended usage levels?
A: Recommended usage varies by application:
- Face serums: 0.01% – 0.03%
- Moisturizers: 0.005% – 0.02%
- Leave-on products: 0.005% – 0.05%
- General range: 0.01% – 0.5%
Please confirm the applicable usage limit for your target market before finalizing your formula.
Q: At what stage should Pentapeptide-18 be added to formulations?
A: Add during the cooling phase (below 45°C) at the final stage of formulation to preserve peptide bioactivity.
Q: What ingredients work well with Pentapeptide-18?
A: Pentapeptide-18 works synergistically with:
- Acetyl Hexapeptide-8 – a complementary cosmetic peptide
- Vitamin C derivatives – for antioxidant support
- Other peptides – including Palmitoyl Tripeptide-1 for elasticity support
Q: Is Pentapeptide-18 heat‑stable?
A: Pentapeptide-18 should be added during the cooling phase (below 45°C) to avoid thermal degradation. Lyophilized powder should be stored refrigerated (2°C – 8°C).
How To Contact Us?
For bulk inquiries, samples, or custom specifications, please contact our sales team. We look forward to partnering with you for high-quality Pentapeptide-18 Powder that meets your exact requirements.
If you need this product, please get in touch with us at ella.zhang@huilinbio-tech.com.
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